Synthesis, Spectral Characterization and Antimicrobial Activity

The chance of discovering a new drug is 1 in 10,000 and development costs about 40 million dollars per new drug. This gives the emphasis on the development of new scientific approaches in the discovery of new drugs, "Drug design". It involves the study of the effects of biologically active compounds on the basis of molecular interactions in terms of molecular structure or its physiochemical properties.The current trend in drug design is to develop new clinically effective agents through the structural modification of the lead nucleus which is a prototype compound that has the desired pharmacological activity but may have many undesirable characteristics. The identification of such lead compounds and optimum bioactive position on the basic skeleton is the area of drug design.