Synthesis of some complexes as structural models of Ada protein | Complexes design and application for mimicing of Ada-Protein

Nagi El- Shafai

ISBN 10: 3659160520 / ISBN 13: 9783659160523

Published by LAP Lambert Academic Publishing, 2012

About this Item

Synthesis of some complexes as structural models of Ada protein | Complexes design and application for mimicing of Ada-Protein | Nagi El- Shafai | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659160523 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106405184

Bibliographic Details

• Title: Synthesis of some complexes as structural models of Ada protein | Complexes design and application for mimicing of Ada-Protein
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659160520
• ISBN 13: 9783659160523
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Ada protein use in repairs methyl phosphotriesters in DNA by direct,irreversible transfer of the methyl groupto one of its cysteines, Cys69.This methyl transfer results in an irreversible loss of repair activity,So,the purpose of our study design and synthesis of polydentate metal(II) complexes, which structurally and functionally mimic the active site of sulfur-containing enzymes, and study of their activities toward the methylation reactions using methyl iodide as methylating agent. Consequently these metal(II) model complexes were used as potential bioinorganic catalysts to yield insight in the mechanism of action of these alkylating enzymes. The results obtained during the study that nickel(II) metal ion is active than other metal ions [(Co(II), Cu(II) and Zn(II)], where it is the most effective electron-withdrawing ion and has the greatest electrophilicity. There it can activate the thiolate nucleophile most effectively than other metal ions.The zinc(II) thiolate complex is the opposite and has the lowest methylation reactions.

About the Author

Nagi M.EL-Shafai born in Kafer EL-Sheikh,Egypt in 1979. B.Sc received in 2002 and M Sc in 2008 from Kafer EL-Sheikh university. Member of research team in Kafer EL-Sheikh university. Experience in UV,FT-IR,TGA & DTA technique,XRD, Zeta potential and cyclovoltmetry techniques). Current research interests include nanotechniques