Synthetic Methodologies ~ Biologically Relevant "Privileged Scaffold"

Botta, Lorenzo

ISBN 10: 3659937584 / ISBN 13: 9783659937583

Published by LAP LAMBERT Academic Publishing, 2019

About this Item

Zustand: Hervorragend | Sprache: Englisch | Produktart: Bücher | Privileged structures are molecular scaffolds with versatile binding properties, such that a single scaffold is able to provide potent and selective ligands for a range of different biological targets through the simple manipulation of the functional groups. In addition, privileged structures typically exhibit good drug-like properties, which in turn leads to more drug-like compound libraries and leads. In this book the possibility to develop a versatile methodology for the syntheis of biologically relevant privileged scaffolds is deeply explored. The first part of the book is focused on the development of a multicomponent approach for the synthesis of Dihydropirans and Sugars. The second part of the book is focused on the synthesis and the biological evaluation, against HIV virus, of derivatives with a rhodaninc structure. Finally, the third part regards the attemps to synthesize the indenic privileged structure as a strategy to obtain the natural product Cyanosporoside.

Seller Inventory # 34225162/1

Bibliographic Details

• Title: Synthetic Methodologies ~ Biologically Relevant "Privileged Scaffold"
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2019
• Language: English
• ISBN 10: 3659937584
• ISBN 13: 9783659937583
• Binding: Soft cover
• Condition: Hervorragend
• Seller catalogs:
  • Bücher

About this title

Synopsis

Privileged structures are molecular scaffolds with versatile binding properties, such that a single scaffold is able to provide potent and selective ligands for a range of different biological targets through the simple manipulation of the functional groups. In addition, privileged structures typically exhibit good drug-like properties, which in turn leads to more drug-like compound libraries and leads. In this book the possibility to develop a versatile methodology for the syntheis of biologically relevant privileged scaffolds is deeply explored. The first part of the book is focused on the development of a multicomponent approach for the synthesis of Dihydropirans and Sugars. The second part of the book is focused on the synthesis and the biological evaluation, against HIV virus, of derivatives with a rhodaninc structure. Finally, the third part regards the attemps to synthesize the indenic privileged structure as a strategy to obtain the natural product Cyanosporoside.