Synopsis
For many healthcare professionals there is a mystery surrounding systematic reviews of healthcare literature. How did they select certain studies and reject others? What did they do to pool results? How did a bunch of insignificant findings suddenly become significant? With this book you will embark on a journey that will provide the key information required to demystify these intrigues. By understanding the principles behind reviews of healthcare literature, you will be able to assess the credibility of the recommendations handed down to you in published reviews and practice guidelines. Following the success of the first edition, Systematic Reviews to Support Evidence-based Medicine simplifies and explains the key steps involved in reviewing literature, directing its deliberations at a readership of nurses, doctors, allied health professionals, public health personnel, new reviewers and students of epidemiology and health technology assessment. This second edition retains the strong emphasis on effectiveness, but the reader is presented with six brand new case studies, and all of the original material has been thoroughly edited and revised to bring it up to date and bring it in line with current knowledge. The authors are veterans of over 150 systematic reviews. Over the years they have worked with healthcare commissioners, clinicians and other decision-makers, producing reviews to inform policy and practice. They have collaborated with other epidemiologists and statisticians to advance methods for undertaking systematic reviews and between them, they have a wide and appropriate range of experience of reviewing and applying findings of healthcare research. Written in a concise and easy-to-digest form, and avoiding technical jargon, Systematic Reviews to Support Evidence-based Medicine remains a must-read for all healthcare professionals.
About the Authors
Khalid S Khan is Professor of Women's Health and Clinical Epidemiology at Barts and the London Medical School in Queen Mary, University of London. He is a clinician, trained in systematic reviews and evidence-based medicine (EBM). Qualified in medical education, he runs journal club and other EBM activities, including evidence-supported ward rounds and workshops on critical appraisal. As a clinical academic he leads a number of systematic review projects, teaches undergraduates and postgraduates, and provides peer review to several clinical journals.
Regina Kunz has recently been appointed Director of the Institute for Insurance Medicine at the University and University Hospital Basel, Switzerland. Nephrologist and clinical epidemiologist by training, she has comprehensive expertise in doing systematic reviews, meta-analyses and health technology assessments. Then, her clinical practice reminded her day by day how important it is to have high quality syntheses at hand when advising patients and making management decisions. Today, the lack of high quality evidence synthesis in insurance medicine is a painful experience that urgently needs change. Her academic activities within the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group on guideline methodology and as a long-standing board member of the Guidelines International Network G-I-N corroborate the need for high quality reviews and meta-analyses in all areas of healthcare, to provide physicians, patients and decision makers with sound recommendations, and the difficulties of delivering convincing recommendations in the absence of such reviews. She is the founding member of the German Network EbM, editor of the German textbook Evidence-based Medicine in Clinic and Practice, and has a great deal of experience in running teaching courses on systematic reviews and meta-analyses, the GRADE-methodology and evidence-based medicine worldwide.
Jos Kleijnen is the Director of an independent company, Kleijnen Systematic Reviews Ltd and Professor of Systematic Reviews in Health Care and Maastricht University. Following his graduation from medical school, he pursued a career as a clinical epidemiologist and has a wealth of experience in conducting and disseminating systematic reviews and other research. He is a member of various steering groups and advisory committees related to systematic reviews and health technology assessment. He was the founding Director of the Dutch Cochrane Centre, Professor and Director of the Centre for Reviews and Dissemination at the University of York, and is a member of several Methods Working Groups of the Cochrane Collaboration. He is an editor of the Cochrane Peripheral Vascular Diseases Review Group and also teaches in courses on systematic reviews and EBM in several countries. This includes a collaboration with the Horten Centre in Zurich, Switzerland and with the Vienna School of Clinical Research in Vienna.
Gerd Antes is the Director of the German Cochrane Centre, Freiburg. He is a medical statistician and has in-depth knowledge of the mathematics behind meta-analyses, heterogeneity, funnel plots, etc. As well as his interests in methodological work, statistical computing and medical informatics, he set up the German Cochrane initiative and spends considerable time supporting the progress of EBM and systematic reviews. He has been a founding member and previous president of the German EBM Network. He has also been a member of the Cochrane Collaboration Steering Group for several years. He is a member of the German Committee for Clinical Guidelines and of the German Commission for Vaccination. One of his activities includes teaching and training science journalists. He has also successfully contributed to establish the German Register for Clinical Trials.
Khalid S Khan is Professor of Women's Health and Clinical Epidemiology at Barts and the London Medical School in Queen Mary, University of London. He is a clinician, trained in systematic reviews and evidence-based medicine (EBM). Qualified in medical education, he runs journal club and other EBM activities, including evidence-supported ward rounds and workshops on critical appraisal. As a clinical academic he leads a number of systematic review projects, teaches undergraduates and postgraduates, and provides peer review to several clinical journals.
Regina Kunz has recently been appointed Director of the Institute for Insurance Medicine at the University and University Hospital Basel, Switzerland. Nephrologist and clinical epidemiologist by training, she has comprehensive expertise in doing systematic reviews, meta-analyses and health technology assessments. Then, her clinical practice reminded her day by day how important it is to have high quality syntheses at hand when advising patients and making management decisions. Today, the lack of high quality evidence synthesis in insurance medicine is a painful experience that urgently needs change. Her academic activities within the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group on guideline methodology and as a long-standing board member of the Guidelines International Network G-I-N corroborate the need for high quality reviews and meta-analyses in all areas of healthcare, to provide physicians, patients and decision makers with sound recommendations, and the difficulties of delivering convincing recommendations in the absence of such reviews. She is the founding member of the German Network EbM, editor of the German textbook Evidence-based Medicine in Clinic and Practice, and has a great deal of experience in running teaching courses on systematic reviews and meta-analyses, the GRADE-methodology and evidence-based medicine worldwide.
Jos Kleijnen is the Director of an independent company, Kleijnen Systematic Reviews Ltd and Professor of Systematic Reviews in Health Care and Maastricht University. Following his graduation from medical school, he pursued a career as a clinical epidemiologist and has a wealth of experience in conducting and disseminating systematic reviews and other research. He is a member of various steering groups and advisory committees related to systematic reviews and health technology assessment. He was the founding Director of the Dutch Cochrane Centre, Professor and Director of the Centre for Reviews and Dissemination at the University of York, and is a member of several Methods Working Groups of the Cochrane Collaboration. He is an editor of the Cochrane Peripheral Vascular Diseases Review Group and also teaches in courses on systematic reviews and EBM in several countries. This includes a collaboration with the Horten Centre in Zurich, Switzerland and with the Vienna School of Clinical Research in Vienna.
Gerd Antes is the Director of the German Cochrane Centre, Freiburg. He is a medical statistician and has in-depth knowledge of the mathematics behind meta-analyses, heterogeneity, funnel plots, etc. As well as his interests in methodological work, statistical computing and medical informatics, he set up the German Cochrane initiative and spends considerable time supporting the progress of EBM and systematic reviews. He has been a founding member and previous president of the German EBM Network. He has also been a member of the Cochrane Collaboration Steering Group for several years. He is a member of the German Committee for Clinical Guidelines and of the German Commission for Vaccination. One of his activities includes teaching and training science journalists. He has also successfully contributed to establish the German Register for Clinical Trials.
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