Testosterone - Action, Deficiency, Substitution

The first edition of "Testosterone: Action, Deficiency, Substitu­ tion" was published in 1990. Since then our understanding of the hormone that turns males into men has tremendously increased. Therefore, the editors felt that a second extended edition of the book is warranted in order to summarize established and recent findings in the field and to present the reader with an up-to-date is reflected by the textbook. The increased mass of knowledge growth of the volume from 14 to 20 chapters. In the updated edition the biochemistry and metabolism of androgens have been complemented by extensive information on the molecular biology of the androgen receptor and its disorders. The key role of testosterone in spermatogenesis is now better de­ fined. We have a more complete understanding of the psychotro­ pic effects of testosterone and know so much about the different target organs and functions that individual chapters deal with testosterone and the prostate, lipids and the cardiovascular sys­ tem, hair, bones and muscles. The general chapter on pharmacol­ ogy and clinical uses of testosterone, in particular in male hypo­ gonadism, is extended by pharmacokinetic studies on testoster­ one preparations and individual substitution modalities using testosterone esters as well as implants and advanced trans dermal applications. The physiologic basis and possible clinical applica­ tions of testosterone in non-gonadal diseases, in male senes­ cence, in hormonal male contraception and in transsexuals are discussed. The last chapter describes the role of "investigative" steroid biochemistry applied to tracking anabolic steroid abuse.

New developments in testosterone action and therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in 20 chapters. This 2nd edition has been thoroughly revised and extended. The book presents the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Effects on bones, muscles, lipids, hair, the prostate, and the brain are considered in separate chapters. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. The pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations are discussed in detail, and side effects of testosterone treatment are reviewed. This is the state-of-the-art book about testosterone action and therapy for endocrinologists, andrologists, urologists and pharmacologists.