Textbook of Clinical Trials

A comprehensive volume on clinical trials that covers all important disease and therapeutic areas together with methodologies, phase I/II/III studies and other issues.

The volume catalogues the impact of clinical trials on the practice of medicine and discusses the developments and practice of medical statistics. Cancer, cardiovascular disease, dermatological, dental, mental, ophthalmic health, gynaecology and respiratory diseases are all discussed in separate chapters, with discussions on outcome measures, competing risks and statistical models given for each therapy area.


It also presents:
* A history of clinical trials
* A summary of pertinent statistical issues
* How to choose a clinical trial design
* Ethical constraints and considerations
* Clinical trial issues in paediatrics and those involving older patients
* Clinical trials in complementary medicine

Textbook of Clinical Trials highlights the varied ways that clinical trials – particularly randomised controlled trials – have influenced the practice of medicine in many therapeutic areas. It describes the challenges posed by those conducting clinical trials over a range of medical specialities and allied fields and blends the development of clinical trial statistical methodology into this process.

Uniquely this Textbook addresses issues as they impact on patients with diseases in the following specific areas:

• Cancer
• Cardiovascular disease
• Complementary medicine
• Respiratory disease
• Dermatology
• Dental disease and disorders
• Mental health
• Alzheimer’s Disease
• Reproductive health
• Gynaecology

In addition, chapters deal with special issues in children and older patients.

This is an essential reference for all involved with clinical trials. It will be of particular relevance to clinical trialists, whether with administrative, data management and quality, scientific or statistical roles, workers in the pharmaceutical industry, those who sit on ethics committees, work in regulatory departments or grant awarding bodies and doctors taking part in the conduct of clinical trials.

• Pragmatic and readable

Draws together critical information in one key text