Thymus Gland Pathology

The thymus is a gland that over the last two centuries has generated great awareness not only from the anatomical perspective but also for the physiological and pat- logical roles it plays in many disease processes. Prior to the early studies on its th anatomy and physiology in the 18 century, the thymus was believed to perform - usual and curious functions such as purification of the nervous system, providing a protective cushion for the vasculature of the superior mediastinum, fetal nouri- ment, or more spiritual roles such as being the seat of the soul, among others. D- th ing the 19 century important anatomical/physiological studies took place focusing on the role of the thymus in pathological conditions. However, it was not until the th middle of the 19 century that a more comprehensive analysis of the role of the thymic gland and its role in pathogenesis began to emerge. Currently, while the knowledge gained on the diverse aspects of the thymic gland has furthered our understanding of its role in a gamut of processes, more knowledge is still being sought, and by no means is a full understanding of the gland’s physi- ogy and pathology complete. Different aspects, including its purported endocrine function, its association with other autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and lupus erythematosus, among others, are under evaluation and research.

The thymus has been a mysterious gland for centuries. The awareness of its role has been progressing, in particular during the second half of the twentieth century.

The thymic pathology is related to several complex congenital, non-oncological, and oncological diseases. Many of these illnesses require a multidisciplinary approach thus involving several specialists: the surgeon, the neurologist, the anesthetist, and the pathologist. For example, myasthenia gravis―the most challenging disease deriving from a thymic trouble―requires an accurate and multimodal treatment. The oncologic pathology of the thymus is likewise complex, and involves also the oncologist and the radiotherapist. In cases of congenital thymic diseases, a transplantation of the thymus can be taken into consideration.

This volume is an update on the pathology of this gland and includes 24 chapters written by international and well-known experts. The whole thymic pathology is described and new conceptsabout the nosological classification and the thymic neoplasm staging system are reported. Some chapters are focused on the radiologic, mini-invasive, and surgical diagnosis, and other chapters deal with surgical and non-surgical treatments. Special chapters are devoted to myasthenia gravis and thymus transplantation.

The book will appeal to all the specialists involved in the treatment of thymic pathology, but can also be of interest to practitioners, and undergraduate and graduate students.