Thymus Transcriptome and Cell Biology

Geraldo A. Passos

ISBN 10: 3031779207 / ISBN 13: 9783031779206

Published by Springer, 2025

About this Item

Druck auf Anfrage Neuware - Printed after ordering - This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance.The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function isassociated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases.This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field.

Seller Inventory # 9783031779206

Bibliographic Details

• Title: Thymus Transcriptome and Cell Biology
• Publisher: Springer
• Publication Date: 2025
• Language: English
• ISBN 10: 3031779207
• ISBN 13: 9783031779206
• Binding: Buch
• Edition: 2nd Edition
• Condition: Neu
• Dimensions: 241W x 160H x 25D millimeters 241 millimeters width by 160 millimeters height by 25 millimeters depth
• Weight: 686 grams

About this title

Synopsis

Angola 1:1,400,000 incl. Cabinda Travel Map, waterproof, GPS-compatible, REISE

This map is waterproof and tear-resistant, highly durable in tropical climate of Angola, double-sided to provide the best balance between a good scale and a convenient sheet size (size 100 x 70 cm / 39.5 x 27.5 in), with topographic and tourist information.

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