Tissue Engineered Scaffolds for Nerve Regeneration | Gradients of Molecules Enhance Nerve Regeneration

Mahesh Chandra Dodla

ISBN 10: 3639433882 / ISBN 13: 9783639433883

Published by AV Akademikerverlag, 2012

About this Item

Tissue Engineered Scaffolds for Nerve Regeneration | Gradients of Molecules Enhance Nerve Regeneration | Mahesh Chandra Dodla | Taschenbuch | 164 S. | Englisch | 2012 | AV Akademikerverlag | EAN 9783639433883 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Seller Inventory # 106397304

Bibliographic Details

• Title: Tissue Engineered Scaffolds for Nerve Regeneration | Gradients of Molecules Enhance Nerve Regeneration
• Publisher: AV Akademikerverlag
• Publication Date: 2012
• Language: English
• ISBN 10: 3639433882
• ISBN 13: 9783639433883
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 11D millimeters 220 millimeters width by 150 millimeters height by 11 millimeters depth
• Weight: 262 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Revision with unchanged content. Injuries to the nervous system result in severe loss of motor and sensory functions. Nerve autografts are widely used clinically to repair injured nerves. However, nerve grafts have many limitations, including availability and loss of function at donor site. To overcome these problems, we have used a tissue engineering approach to design three-dimensional (3D) scaffolds containing laminin-1 (LN-1) and nerve growth factor (NGF). After nerve injury and during embryonic development, several extra-cellular matrix molecules and neurotrophic factors contribute to nerve regeneration and repair. Our 3D agarose hydrogel scaffolds with gradients of LN-1 and NGF are designed to mimic these in vivo conditions to promote nerve regeneration in rats. These scaffolds have shown to promote nerve regeneration comparable to using nerve autografts in rats. This book, therefore, provides a novel technique of nerve scaffold preparation for greater success in nerve regeneration. Scientists and students of neural engineering could use this technique to design novel scaffolds. Optimization of this technique could result in a viable alternative to using nerve grafts for nerve regeneration.

About the Author

post-doctoral associate at University of Georgia,U.S.A. He received his Bachelors degree inBiotechnology at Indian Institute of Technology,India, and his Doctoral degree in BiomedicalEngineering at Georgia Institute of Technology,U.S.A. He is currently working on using Stem celltechnology for nerve repair.