Hardcover. Toxicogenomics-Based Cellular Models: Alternatives to Animal Testing for Safety Assessment Suitable for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety, this book offers information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Bibliographic Details

Title: Toxicogenomics-Based Cellular Models (Hardcover)
Publisher: Elsevier Science Publishing Co Inc, San Diego
Publication Date: 2014
Language: English
ISBN 10: 0123978629
ISBN 13: 9780123978622
Binding: Hardcover
Condition: new

About this title

Synopsis

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity
Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays
Includes an overview of current testing methods and risk assessment frameworks
Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward

Review

"Researchers in genetics, toxicology, and other medical and public health specialties describe the current progress in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, and reproductive toxicity, all important endpoint of toxicity, the evaluation of which now costs large numbers of animal lives."--ProtoView.com, April 2014

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