Transcription Induction Integrated by Nuclear Receptor Coregulators | Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate

Eric Dammer

ISBN 10: 3836475324 / ISBN 13: 9783836475327

Published by VDM Verlag Dr. Müller, 2009

About this Item

Transcription Induction Integrated by Nuclear Receptor Coregulators | Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate | Eric Dammer | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783836475327 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

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Bibliographic Details

• Title: Transcription Induction Integrated by Nuclear Receptor Coregulators | Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate
• Publisher: VDM Verlag Dr. Müller
• Publication Date: 2009
• Language: English
• ISBN 10: 3836475324
• ISBN 13: 9783836475327
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Studies carried out during the past decade have shown that transcription of inducible eukaryotic genes involves sequential chromatin modifications by promoter-specific transcription factors and a class of proteins called transcription coregulators. First, this work identifed important chromatin modifications and modifying complexes at the CYP17 transcription start site and nearby steroidogenic factor-1 (SF-1) binding site. Post translational modifications (PTMs) to SF-1 also occur as this transcription factor interacts with the promoter. In addition, ACTH/cAMP signaling in adrenal cortex alters SF-1-containing chromatin- modifying complexes during the early phase of transcriptional induction of CYP17. Chromatin IP (ChIP) and mammalian two hybrid experiments identified complexes which are cAMP-inducible, but sensitive to the SF-1 antagonist sphingosine. SF-1 PTMs at the ligand binding pocket opening were found to be required for CYP17 transcription. Last, certain corepressors are protein kinase A (PKA) targets and are functionally sensitive to PKA- dependent NADH accumulation. Thus, signaling, metabolism, and transcription are integrated.

About the Author

Eric Dammer was raised in Bergen County, New Jersey. He studied at UC Santa Cruz and later finished undergraduate studies at Florida Gulf Coast University in Ft. Myers, Florida in 2003. He was an HHMI intern at Georgia Tech before entering the Biology PhD program 2003-2008. He is currently a postdoc at Emory University in Atlanta, GA.