Transdermal Patches Of An Antihypertensive Drug: Formulation And In-vitro Evaluation

Patil, Shitalkumar

ISBN 10: 3659507784 / ISBN 13: 9783659507786

Published by LAP LAMBERT Academic Publishing, 2013

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Bibliographic Details

• Title: Transdermal Patches Of An Antihypertensive Drug: Formulation And In-vitro Evaluation
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659507784
• ISBN 13: 9783659507786
• Binding: paperback
• Condition: New
• Book Type: book

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Synopsis

The main focus of this research work was to develop a matrix type transdermal patch containing Propranolol hydrochloride and combination of two hydrophobic Polymers Eudragit L-100 and Eudragit S-100 by Solvent Evaporation technique.Combination of two Plasticizers Glycerine and Dibutyl phthalate were used and their effect on drug release was studied by changing their concentration in each batch.Methanol and Dichloromethane solvent system was used in which methanol acts as a penetration enhancer.Since oral bioavaibility of Propranolol Hydrochloride is poor due to high first pass metabolism transdermal patch is formed with the objective to get sustained release drug action with good bioavaibility. It can be concluded that the attempt of formulation and evaluation of the propranolol hydrochloride patches was found to be successful in the release of drug for an extended period of time. Further detailed investigations and elaborate in-vivo studies need to be carried out and an in-vitro in-vivo correlation need to established to guarantee the efficiency and bioavaibility of the formulation.

About the Author

Dr, Shitalkumar Patil is working as Professor and Principal in Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Tal. Hatkanangale, Dist. Kolhapur, Maharashtra, India having more than 23 years of experience in Academia and Industry. He has more than 30 publication and 15 presentations in various national and international journals and conferences.