Transduction Mechanisms in Cellular Signaling

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences.

• Articles written and edited by experts in the field
• Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses
• Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover.