Translational Research in Traumatic Brain Injury

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow.

Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas:

• Epidemiology
• Pathophysiology
• Diagnosis
• Current treatment strategies and sequelae
• Future therapies

Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Edited by

Daniel Laskowitz, MD, MHS, professor of neurology, anesthesiology & neurobiology; and director, Neurovascular Laboratories, Duke University Medical Center, Durham, North Carolina, USA

Gerald A. Grant, MD, FACS, division chief, Pediatric Neurosurgery; vice chair for pediatric neurosurgery and associate program director; and associate professor, Department of Neurosurgery; Stanford University/Lucile Packard Children's Hospital, California, USA