Transmembrane Signalling, Intracellular Messengers and Implications for Drug Development

Transmembrane Signalling, Intracellular Messengers and Implications for Drug Development

Edited by Stefan R. Nahorski, Department of Pharmacology and Therapeutics, University of Leicester, UK

The concept of membrane receptors as components that recognise extracellular ligands and translate their binding into appropriate intracellular responses has been central to pharmacology for more than a century. However, the last few years have seen such remarkable developments at the molecular level that it seems certain that the discipline of pharmacology will be transformed. Molecular information is radically advancing our understanding of receptor ? effector systems and will open up entirely novel approaches to the development of new drugs.

In this book the latest developments in receptor structure, transmembrane signalling, second messenger generation and second messenger action are discussed by distinguished international experts from the leading laboratories in the United Kingdom, Europe and the United States. Perhaps uniquely in a single volume, it provides authoritative access to each of these areas and gives a focused overview for the future drug manipulation of transmembrane signalling.

Books of related interest from Wiley? Molecular Pharmacology of Cell Regulation Volume 1: G-proteins as mediators of cellular signalling processes Edited by M.D. Houslay and G. Milligan 0-471-92338-9 233 pages 1990

Volume 2: Isoenzymes of cyclic nucleotide phosphodiesterases Edited by J. Beavo and M.D. Houslay 0-471-92707-4 (due July 1990)

Molecular information is greatly advancing our understanding of receptor-effector systems, opening up entirely novel approaches to the development of new drugs. In this book, distinguished experts from leading laboratories in the U.S., Great Britain and Europe discuss the latest developments in receptor structure, transmembrane signalling, second messenger generation and second messenger action. Perhaps uniquely in a single volume, this work provides authoritative access to each of these areas and gives a focused overview for the future drug manipulation of transmembrane signalling.