Transporters in Drug Development : Discovery, Optimization, Clinical Study and Regulation

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Yuichi Sugiyama had been the Professor, Department of Molecular Pharmacokinetics at the University of Tokyo since 1991, retired from the University of Tokyo, 2012. He is now working as the Head of Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, Yokohama, Japan. He is a coauthor of more than 580 publications in international journals as well as 270 book chapters and review articles. His research focuses on two areas: 1) Physiologically based pharmacokinetics (In vitro/in vivo extrapolation): 2) Molecular pharmacokinetics of drug transport in liver, kidney, intestine and brain.

His work is internationally recognized by prestigious awards, including AAPS Distinguished Pharmaceutical Scientist Award, 2003, FIP Hoest Madsen Gold Medal in 2009, "Medal with Purple Ribbon" given by Government in 2010 and B.Brodie Award from ASPET in 2012. According to a recent report of ISI Essential Science Indicators, Professor Sugiyama has been ranked as the top (#1) cited scientist in the field of Pharmacology & Toxicology (1997-2007). He served as the chairman of Board of Pharmaceutical Sciences in FIP (2000-2004). He was also the president of both “International society for the study of xenobiotics (ISSX)” and “Japanese Society for Xenobiotic Metabolism and Disposition (JSSX)”.(2006-2007).