Treatment of Advanced Stage Cancers: Current Status and Emerging Frontiers

Treatment of Advanced Stage Cancers describes newer options for treatment of advanced liver cancers; targeting of pancreatic cancers by silencing' RNA selective killing of tumour cells expressing hCG by a high affinity, high specificity antibody linked to curcumin.

Reviewed also are the next generation of recombinant immunotoxins; herbal formulations eliminating Human Papilloma Virus (HPV) in cervical cancer cells besides immune targeting of oncogenic proteins of HPV to achieve a therapeutic vaccine for carcinoma of cervix. The book discusses optimisation of antigens for anti-cancer vaccines and optimization of Dendritic cells and viral vectors for immunotherapy. Clinical and experimental results are reported on therapeutic benefits of cancers by Mycobacterium indicus pranii. (DCGI approved vaccine for leprosy marketed as Immuvac).

Other topics covered include treatment of Chronic Myeloid Leukemia, Radiation-Enhanced Immunotherapy of Advanced cancers, Neem leaf glycoproteins regulating immune response in cancer and biology of metastasis of Head and Neck cancers. A new blood test for early diagnosis of Epithelial Ovarian Cancers is also described. The opening chapter by the Nobel Laureate David Baltimore presents elegantly the role of Micro RNAs in chronic inflammatory response and cancers.

Table of Contents

• Preface
• Micro RNAs and the Inflammatory Response
• Therapeutic Significance of Increased Tissue Transglutaminase Expression in Pancreatic Cancer
• Novel Si-RNA-Ribozyme Constructs Against HIV-1 and X Gene of Hepatitis Virusess
• Newer Treatment Options for Advanced Liver Cancer
• Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
• Mechanism of Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia (CML)
• Mechanisms of Multiple Forms of Tumorigenesis in LH/hcg Overexpressing Transgenic Mice
• Targeted Therapy of ?-hCG Expressing Cancers
• The Next Generation of Recombinant Immunotoxins: Targeting CD30 Receptor
• CD40 and Cancer Therapy
• Optimization of Antigens for use in Anti-Cancer Vaccines
• Immune Targeting of Oncogenic Proteins of High Risk Human Papilloma Virus Type 16 (HPV 16)
• Elimination of HPV and Control of Viral Oncogene Expression in Cervical Cancer Cells by Herbal Compounds
• Optimization of Dendritic Cells and Adenoviral Vectors for Immunotherapy of Cancer
• Phase-One Clinical Trial of Dendritic Cell Vaccines for Human Papillomavirus Positive Cervical Cancer
• Radiation-Enhanced Immunotherapy for Advanced Cancer
• Cancer Immunoediting: Professional Editorship by Neem Leaf Glycoprotein
• Suppression of Suppressors: Neem Leaf Glycoprotein Guided Crosstalk between Regulatory T Cells and T Cells/Nk Cells/Macrophages in Cancer
• Mycobacterium Indicus Pranii Vaccine (Mw) in Cancers
• Biology of Head and Neck Cancer Metastasis
• MTA Family of Master Co-regulators in Invasion and Metastasis
• Role of Hormonal and Cytokine Environment of Tumor-bearing Host in Manifestation of Gender-Dependent Differential Induction of Apoptosis of Tumor Cells: Implication in Gender Dimorphism of Tumor Growth
• Humoral Immune Response Against Sperm Associated Antigen 9 (SPAG9) in Epithelial Ovarian Cancer
• Molecular Staging of Glial Tumors
• Tumour Microenvironment and Inflammation: Role in Glioblastoma Progression
• Seeding the Discovery and Development of New Drugs for Advanced-Stage Cancers
• Index.

G. P. Talwar.: Director Research Talwar Research Foundation, New Delhi O.P. Sood.: Ranbaxy Science Foundation, New Delhi