Tuberous sclerosis complex : from basic science to clinical phenotypes

Paolo Curatolo

ISBN 10: 1898683395 / ISBN 13: 9781898683391

Published by Mac Keith Press, 2003

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes. This book correlates genetic data and basic science, covers clinical presentation, reviews the historical background and diagnostic criteria, and presents an overview of neuropathology, molecular genetics and neurobiology in order to give a better understanding of the pathogenesis of the disease. Paediatricians and child neurologists will find this book uniquely useful.

Seller Inventory # 9781898683391

Bibliographic Details

• Title: Tuberous sclerosis complex : from basic science to clinical phenotypes
• Publisher: Mac Keith Press
• Publication Date: 2003
• Language: English
• ISBN 10: 1898683395
• ISBN 13: 9781898683391
• Binding: Buch
• Condition: Neu
• Dimensions: 240W x 161H x 22D millimeters 240 millimeters width by 161 millimeters height by 22 millimeters depth
• Weight: 661 grams

About this title

Synopsis

"This is clearly the most authoritative and contemporary statement of current knowledge yet published."
from the Foreword by H. Sarnat

Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes.

This book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease.

Paediatricians and child neurologists will find this book uniquely useful.

About the Author

Edited by Paolo Curatolo, Università degli Studi di Roma 'Tor Vergata'