Oxidative stress is caused by various intrinsic and extrinsic factors. It has been widely accepted that dietary or dietary supplement interventions can decrease levels of oxidative stress. Natural bioactive compounds (flavonoids, stilbenes, terpenes, alkaloids, saponins, polysaccharides, etc.) have been reported to exhibit multiple health-promoting effects, including antioxidant activity. However, the underlying cellular signaling and molecular mechanisms of their effect in ameliorating oxidative stress are not fully understood. In this Special Issue, we have collected and summarized the antioxidant activities of natural bioactive compounds based on the studies from cell culture models, animal models, and clinical trials. This Special Issue contains twelve papers covering the above-mentioned topics, including one systematic review and meta-analysis, one editorial, and ten research papers.

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