Cells face and react to their environment to ensure viability or to fulfil specialized tasks. Therefore, they evolved highly coordinated interconnected signalling networks to sense extra- or intra-cellular stimuli and generate diverse changes in the cellular physiology ranging from transcription modification to the activation or repression of various protein functions. These signalling networks often include molecules that can be covalently attached to other molecules such as proteins, nucleic acids, or lipids to alter their affinities towards binding partners. Alternatively, such attachments may modulate the enzymatic activity of the modified proteins or affect their cellular localization. These attachments, commonly referred as post-translational modifications (PTMs), generate quicker responses and initiate instant downstream signalling compared to the transcription/translation machinery (Walsh and Jefferis, 2006). PTMs usually involve reversible covalent attachment of molecules such as phosphate, methyl or acetyl groups to proteins (Cohen, 2001; Walsh and Jefferis, 2006; Yang and Seto, 2008). Additionally, proteins in eukaryotes may get modified by covalent attachment of small proteins like ubiquitin (Ub), SUMO (Small ubiquitin-related modifier), or Nedd8. These modifications are often classified as UbLyations and the modifiers as UbLs (Ubiquitin Like proteins) as Ub was the first one to be identified and characterized amongst these. In fact, the attachment of Ub has been established to play many cellular roles as it can alter the function as well as the fate of the substrate proteins.

"About this title" may belong to another edition of this title.

Store Description

GreatBookPrices.com is your top source for finding new books at the absolute lowest prices, guaranteed ! We offer big discounts - everyday - on millions of titles in virtually any category, from Architecture to Zoology -- and everything in between. Discover great deals and super-savings, on professional books, text book titles, the newest computer guides, or your favorite fiction authors. You'll find it all - at HUGE SAVINGS - at GreatBookPrices. Browse through our complete online product catalog today. Serving customers around the world for years, we help thousands find just the books they're looking for -- at incredibly low, bargain prices.

Visit Seller's Storefront

Seller's business information

Far Corner Europe Limited
19-20 Bourne Court, 19-20 Bourne Court, Woodford Green, IG8 8HD, United Kingdom

Sale & Shipping Terms

Terms of Sale

Company Name: GreatBookPricesUK
Legal Entity: Far Corner Europe Limited
Address: 19-20 Bourne Court, Southend Road, Woodford Green Essex, UK IG8 8HD
Registration #: 10691061
Authorized representative: Danielle Hainsey

Shipping Terms

Our warehouses across the globe are fully operational without substantial delays. We are working hard and continue to overcome the daily challenges presented by COVID-19. There have been reports that delivery carriers are experiencing large delays resulting in longer than normal deliveries to customers. See USPS's website for further detail. We would like to apologize in advance if your item arrives later than the expected delivery due date.

Internal processing of your order will take about 1-2 business days. Please allow an additional 4-14 business days for Media Mail delivery. We have multiple ship-from locations - MD,IL,NJ,UK,IN,NV,TN & GA

Shipping rates from United Kingdom to U.S.A.

Shipping rates from United Kingdom to U.S.A.
Order quantity	10 to 30 business days	10 to 27 business days
First item	US$ 20.46	US$ 20.46

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.