Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis

El-Banna, Mona

ISBN 10: 6208420326 / ISBN 13: 9786208420321

Published by LAP LAMBERT Academic Publishing, 2025

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Bibliographic Details

• Title: Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2025
• Language: English
• ISBN 10: 6208420326
• ISBN 13: 9786208420321
• Binding: Soft cover
• Condition: New

About this title

Synopsis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by muscle weakness, atrophy, fasciculations, and spasticity due to motor neuron degeneration. Symptoms progress from focal weakness to difficulties in speaking, swallowing, and breathing, with eventual paralysis. The disease arises from mechanisms such as disrupted RNA metabolism (e.g., TDP-43 and FUS mutations), cytoskeletal and axonal transport defects (e.g., PFN1, TUBA4A mutations), excitotoxicity, and oxidative stress. While incurable, treatments like Riluzole and Edaravone can modestly slow progression, and supportive care—such as non-invasive ventilation, feeding tubes, and physical therapy—helps manage symptoms. Emerging therapies, including gene and RNA-targeted approaches, hold promise for the future.