The Unfolded Protein Response Pathway and Lung Cancer : Intervention by phytochemicals

Language: English

Published by LAP LAMBERT Academic Publishing, 2023

6207448529 / 9786207448524

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Cancer's lethality and the shortcomings of current treatments propel the urgency for effective alternatives. Lung Cancer, a leading cause of malignancy-related deaths, is exacerbated by widespread smoking. Decades of research into cancer biology aim to enhance therapeutic efficacy while minimizing side effects. The Unfolded Protein Response (UPR) pathway, pivotal in maintaining protein homeostasis and responding to ER stress, garners significant interest. The molecular chaperone GRP78, integral in cellular processes during ER stress, holds a multifaceted role in lung cancer biology, influencing survival and treatment resistance. Exploring novel treatments, this chapter investigates plant-derived compounds for antioxidant and anti-inflammatory effects, metabolic regulation, and anti-tumor properties with reduced side effects. Emphasizing UPR in lung cancer, it explores phytochemicals (curcumin, nimbolide, epigallocatechin-3-gallate, emodin) inducing cell death and reducing metastasis. The study further establishes potential connections between these compounds and UPR signaling pathways, including PI3K/Akt, MAPK, NF- B, Wnt/beta-catenin, and STAT3 in cancer cells.

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Title
The Unfolded Protein Response Pathway and Lung Cancer : Intervention by phytochemicals
Author
Swatilekha Ghosh
Publisher
LAP LAMBERT Academic Publishing
Publication year
2023
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6207448529
ISBN 13
9786207448524
Item weight
107 grams
Dimensions
220x150x4 mm

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

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