Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions, and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. The book also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies.
The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.
- Provides an interdisciplinary overview of sirtuin biology, bridging foundational science with translational research
- Facilitates the development of sirtuin-targeted therapies for a variety of diseases, including cancer and neurodegenerative disorders
- Highlights cutting-edge tools and technologies for sirtuin analysis
- Includes case studies and step-by-step procedures to support scientists in their own research
Dr. Pranav Kumar Prabhakar is Professor and Head of the Department of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima, Nagaland, India. His research focuses on elucidating molecular mechanisms involved in metabolic disorders, particularly diabetes, including strategies for oral insulin delivery and the use of natural products to mimic signaling pathways. He is a member of the Royal Society of Chemistry and the Asia-Pacific Chemical, Biological & Environmental Engineering Society. Dr. Prabhakar serves on the editorial boards of, and acts as a reviewer for, several national and international scientific journals. He has published extensively in his field and has contributed to numerous books and book chapters. He has also presented his research at scientific meetings and conferences.
Dr. Sumel Ashique has been working as an assistant professor at the Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University, West Bengal, India. He has 5 years of teaching experience. He has achieved 100+ publications in international and national accredited reputed journals. He has expertise in drug delivery, nanotechnology, and targeted treatment strategies. Recently, he was honored to be in the World’s Top 2% Scientists by prestigious Stanford University, CA, United States, and Elsevier in 2025.
