Unraveling the Complexities of Metastasis : Transition from a Segmented View to a Conceptual Continuum

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.

The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.

This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

• Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers
• Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field
• Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and newcomers in the field of cancer metastasis

Ammad Ahmad Farooqi is currently serving as a Senior Scientist at Institute of Biomedical and Genetic Engineering (IBGE). His research-work is tightly focused on cell signaling cascades and how these pathways can be therapeutically exploited. He has published more than 200 articles in International peer-reviewed Journals and has guest edited 2 Books. He has over 5000 citations and an H-index above 37. He is editor of various national and international Journals. He has guest edited various thematic issues related to molecular oncology. He has authored/co- authored more than 25 chapters in various books published by internationally distinguished publishers. He was ranked in the top 10 scientists of biological sciences for 2017/2018 by most prestigious national research steering body, Pakistan Council of Science and Technology (PCST). He was ranked in top 2% scientists of the world in the field of oncology in 2019/2020. According to recently published research, he was ranked as No. 1 Scientist in the field of breast cancer research in Pakistan.

Muhammad Zahid Qureshi, PhD is a Professor of Biochemistry in Qassim University, Saudi Arabia. He received his PhD from Quaid-i-Azam University Islamabad and post-doctorate from Brunel University, London. He has notable contributions in Biochemistry and Molecular Biology. He has authored/co-authored many articles in international Journals and has published seven chapters. His research is focused on molecular cancer and nanotechnology.

Uteuliyev Yerzhan Sabitaliyevich is an academician and reputed scientist from Kazakhstan. He has previously served as a Vice-Rector for academic affairs and research and innovation activities of Kazakhstan Medical University "KSPH". He has notable contributions in scientifically distinguished international journals. He has played key role in inspiring young researchers to make progress in medical field. He has organized series of medical conferences in Kazakhstan to maximize the interaction of local researchers with scientifically eminent researchers from technically advanced countries.