Validation Of Bioanalytical Methods Of Drugs

Language: English

Published by LAP LAMBERT Academic Publishing Sep 2012, 2012

3659237841 / 9783659237843

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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Softcover

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This item is printed on demand - it takes 3-4 days longer - Neuware -In this book a variety of techniques for the extraction of drugs from the plasma matrix have been investigated, the data was subjected to different statistical evaluation procedures, to properly evaluate the measured analytical outcomes. After evaluating the concentration time profiles of pooled samples, previously harvested from dosed human volunteers, the effect of different extraction procedures on the calculated pharmacokinetic parameters was compared. Two types of drugs, classified as Non-Insulin-Dependent Diabetes Mellitus (NIDDM) active ingredients were selected in this study. Glibenclamide was chosen to represent a highly protein bound drug, whereas Metformin was chosen to represent a low protein bound drug. The primary bioanalytical methods validation parameters such as recovery, selectivity, specificity, sensitivity, limit of quantitation and limit of detection, in addition to uncertainty in the analytical measurement have been extensively reviewed. Rigorous approaches using different statistical weights for evaluating calibration data were also derived for each drug using various experimental conditions. 308 pp. Englisch.…

Seller Inventory # 9783659237843

Title
Validation Of Bioanalytical Methods Of Drugs
Author
Adi J. Said
Publisher
LAP LAMBERT Academic Publishing Sep 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659237841
ISBN 13
9783659237843
Item weight
477 grams
Dimensions
220x150x19 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

Shipping rates from Germany to U.S.A.

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BuchWeltWeit Ludwig Meier e.K.

Germany