Virus Variability, Epidemiology and Control

Language: English

Published by Springer US, Springer US Sep 1990, 1990

0306433591 / 9780306433597

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This item is printed on demand - Print on Demand Titel. Neuware -Virus Variability and Impact on Epidemiology and Control of Diseases E. Kurstak and A. Hossain I. INTRODUCTION An important number of virus infections and their epidemic developments demonstrate that ineffec tiveness of prevention measures is often due to the mutation rate and variability of viruses (Kurstak et al., 1984, 1987). The new human immunodeficiency retroviruses and old influenza viruses are only one among several examples of virus variation that prevent, or make very difficult. the production of reliable vaccines. It could be stated that the most important factor limiting the effectiveness of vaccines against virus infections is apparently virus variation. Not much is, how ever, known about the factors influencing and responsible for the dramatically diverse patterns of virus variability. II. MUTATION RATE AND VARIABILITY OF HUMAN AND ANIMAL VIRUSES Mutation is undoubtedly the primary source of variation, and several reports in the literature suggest that extreme variability of some viruses may be a consequence of an unusually high mutation rate (Holland et al., 1982; Domingo et al., 1985; Smith and Inglis, 1987). The mutation rate of a virus is defined as the probability that during a single replication of the virus genome a particular nucleotide position is altered through substitution, deletion, insertion. or recombination. Different techniques have been utilized to measure virus mutation rates, and these have been noted in the extent of application to different viruses.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 396 pp. Englisch.

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Title
Virus Variability, Epidemiology and Control
Author
Edouard Kurstak
Publisher
Springer US, Springer US Sep 1990
Publication year
1990
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0306433591
ISBN 13
9780306433597
Item weight
940 grams
Dimensions
260x183x27 mm

buchversandmimpf2000

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