The In Vivo Study of Drug Action: Principles and Applications of Kinetic-Dynamic Modelling

Hardbound. Pharmacodynamics is the oldest in vitro element of pharmacology and the youngest in vivo element. However, over the last decade there has been significant progress in understanding the kinetics of drug action in vivo and pharmacodynamics now ranks with pharmacokinetics in the content of clinical pharmacology journals. The purpose of this book is to link theory and practice of in vivo pharmacodynamic studies. This presents a major challenge due to the multi-faceted nature of the kinetics of drug actions. The first step involves identification of those effects which represent the actions of a drug using mathematical models in combination with classical receptor theory. Subsequently, these effects must be quantified in a precise and reproducible manner and the pharmacokinetcs of the drug and its active metabolites must be accurately described. Finally, realistic models must be developed which identify the site of action and can d

...I strongly recommend this book to anyone interested in the relationships between drug concentrations and drug effects in vivo. It serves its purpose both as a primer for the research student and as a textbook and support for experienced workers in the field. It should also find its way to colleagues responsible for the development of new drugs and therapeutic strategies within the pharmaceutical industry and the health care system. -- Gunnar Alván, Therapeutic Drug Monitoring, 1994

1994 ...I strongly recommend this book to anyone interested in the relationships between drug concentrations and drug effects in vivo. It serves its purpose both as a primer for the research student and as a textbook and support for experienced workers in the field. It should also find its way to colleagues responsible for the development of new drugs and therapeutic strategies within the pharmaceutical industry and the health care system. -- Gunnar Alván, Therapeutic Drug Monitoring