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History: A medieval multiverse Ideas in a thirteenth-century treatise on the nature of matter still resonate today, say Tom C. B. McLeish and colleagues. Policy: The art of science advice to government Peter Gluckman, New Zealand, s chief science adviser, offers his ten principles for building trust, influence, engagement and independence. Books and Arts Top In retrospect: Sylva Gabriel Hemery celebrates the 350th anniversary of John Evelyn, s treatise on the science and practice of forestry. Review of Sylva, Or a Discourse of Forest-Trees, and the Propagation of Timber in His Majesties Dominions John Evelyn Particle physics: Higgs on the big screen Alexandra Witze savours a behind-the-scenes look at physics, s most famous arrival. Review of Particle Fever Mark Levinson Evolutionary biology: Sex, lies and butterflies David W. Loehlin & Sean B. Carroll See also Letter by Kunte et al. Astrophysics: Cosmic lens reveals spinning black hole Guido Risaliti See also Letter by Reis et al. Geology: Earth, s deep water reservoir Hans Keppler See also Letter by Pearson et al. Neurodegenerative diseases: G-quadruplex poses quadruple threat J. Paul Taylor See also Article by Haeusler et al. Neuroscience: Ordered randomness in fly love songs Bence P. Ölveczky See also Letter by Coen et al. 50 & 100 Years Ago Evolutionary biology: Speciation undone Peter R. Grant & B. Rosemary Grant Articles Top Alveolar progenitor and stem cells in lung development, renewal and cancer Tushar J. Desai, Douglas G. Brownfield & Mark A. Krasnow Lung alveoli are lined by two types of alveolar epithelial cells, squamous alveolar type (AT) 1 cells that mediate gas exchange and cuboidal AT2 cells that secrete surfactant to prevent alveolar collapse during breathing, here alveolar markers, genetic lineage tracing and clonal analysis are used in mice to identify alveolar progenitor and stem cells in vivo, and to map their locations and potential during lung development, maintenance and cancer. C9orf72 nucleotide repeat structures initiate molecular cascades of disease Aaron R. Haeusler, Christopher J. Donnelly, Goran Periz, Eric A. J. Simko, Patrick G. Shaw + et al. Structurally polymorphic C9orf72 hexanucleotide repeats cause an impairment in transcriptional processivity and lead to accumulation of truncated repeat-containing transcripts that bind to specific ribonucleoproteins, such as nucleolin, in a conformation-dependent manner resulting in nucleolar stress and C9orf72-linked pathology in amyotrophic lateral sclerosis and frontotemporal dementia. See also News & Views by Taylor Proof of principle for epitope-focused vaccine design Bruno E. Correia, John T. Bates, Rebecca J. Loomis, Gretchen Baneyx, Chris Carrico + et al. Computational protein design methods are used to generate new candidates for a human respiratory syncytial virus (RSV) vaccine, artificial protein scaffolds that mimic the structure of a RSV epitope are shown to induce RSV-specific neutralizing antibodies in macaques. Letters Top Reflection from the strong gravity regime in a lensed quasar at redshift z = 0.658 R. C. Reis, M. T. Reynolds, J. M. Miller & D. J. Walton Observations of a gravitationally lensed quasar at redshift 0.658 imply a high spin parameter, which indicates that this supermassive black hole grew by coherent accretion rather than in a chaotic manner. See also News & Views by Risaliti Interrogating selectivity in catalysis using molecular vibrations Anat Milo, Elizabeth N. Bess & Matthew S. Sigman A set of parameters based on the response of a molecule s properties to infrared vibrations can be used to model and predict selectivity trends for molecular reactions with interlinked steric and electronic effects at positions of interest Conformation-induced remote meta-C H activation of amines Ri-Yuan Tang, Gang Li & Jin-Quan Yu In anilines and benzylic amines, a recyclable chemical template can direct the olefination and acetoxylation of meta-C H bonds as far as 11 bonds away from a.
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