Vol 508 No. 7496, April 2014, Out of the shadows

nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE

Published by NPG Nature publishing group

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Policy: Bring sustainable energy to the developing world Investment and policies must support cheap, clean energy technologies to cut both poverty and climate change, say Reid Detchon and Richenda Van Leeuwen. Publishing: Credit where credit is due Liz Allen, Amy Brand, Jo Scott, Micah Altman and Marjorie Hlava are trialling digital taxonomies to help researchers to identify their contributions to collaborative projects. Astronomy: Art of the eclipse As the next solar eclipse approaches, Jay M. Pasachoff and Roberta J. M. Olson ponder how artists from the early Renaissance onwards have interpreted the phenomenon. Geology: Parsing eruptions Ted Nield weighs up histories of two momentous volcanic events in Iceland and Indonesia. Review of Island on Fire: The Extraordinary Story of Laki: The Volcano That Turned Eighteenth-Century Europe Dark Tambora: The Eruption That Changed the World Alexandra Witze, Jeff Kanipe & Gillen D'Arcy Wood Animal behaviour: Nomads of necessity Joel Greenberg casts an ornithologist's eye on a wide-ranging reading of animal migration. Review of The Homing Instinct: Meaning and Mystery in Animal Migration Bernd Heinrich Obesity Tony Scully Society at large Tony Scully Cell physiology: The changing colour of fat Brian Owens Treatment: Marginal gains Emily Anthes Perspective: Obesity is not a disease D. L. Katz Heritability: The family roots of obesity Cassandra Willyard Microbiome: A complicated relationship status Sarah Deweerdt Neuroscience: Dissecting appetite Bijal P. Trivedi Perspective: Tricks of the trade Stephen J. Simpson & David Raubenheimer Evolutionary biology: Dating chimpanzees Michael Haslam Genetics: Up and down in Down's syndrome Benjamin D. Pope & David M. Gilbert See also Article by Letourneau et al. Organic chemistry: Catalysis marches on James P. Morken See also Article by Mei et al. Synthetic biology: Biocircuits in synchrony Ricard Solé & Javier Macía See also Letter by Prindle et al. Thermoelectricity: The ugly duckling Joseph P. Heremans See also Letter by Zhao et al. Review Top The ensemble nature of allostery Hesam N. Motlagh, James O. Wrabl, Jing Li & Vincent J. Hilser Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another, often distal, functional site, allowing for the regulation of activity; here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed, and a framework to unify the description of allosteric mechanisms for different systems is proposed. Articles Top Enantioselective construction of remote quaternary stereocentres Tian-Sheng Mei, Harshkumar H. Patel & Matthew S. Sigman A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group. See also News & Views by Morken Domains of genome-wide gene expression dysregulation in Down?s syndrome Audrey Letourneau, Federico A. Santoni, Ximena Bonilla, M. Reza Sailani, David Gonzalez + et al. By studying the transcriptome of fetal cells of monozygotic twins discordant for trisomy 21, this paper finds that differential expression between the twins is organized in domains along all chromosomes; these gene expression dysregulation domains are conserved in the mouse model of Down?s syndrome and correlate with the lamina-associated domains and replication domains. See also News & Views by Pope & Gilbert Brainstem nucleus MdV mediates skilled forelimb motor tasks Maria Soledad Esposito, Paolo Capelli & Silvia Arber The authors use a combination of viral tracing and genetics to characterize the diversity of neurons projecting from mouse brainstem to motor neurons that control limb movements; in particular they discover that the medullary reticular formation ventral part (MdV) is functionally specialized for skilled forelimb motor control. Skilled reaching relies on a V2a propriospinal internal cop.

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Bibliographic Details

• Title: Vol 508 No. 7496, April 2014, Out of the shadows
• Publisher: NPG Nature publishing group
• Binding: Hardcover
• Weight: 400 grams