WNT Signaling in Development and Disease

Wnt Signaling in Development and Disease, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer.

• Presents newest findings on the role of Wnt signaling in a variety of tissues and organisms
• Illustrates the diverse actions of Wnt signaling in development and disease
• Highlight tools and technologies to interrogate Wnt signaling in any biological system

Terry P. Yamaguchi is at NCI-Frederick, MD, USA

Karl Willert is at Sanford Consortium for Regenerative Medicine, CA, USA