The majority of patients in need of organ transplants do not survive long enough for a suitable human organ to become available. Xenotransplantation, the transplantation of animal organs into humans, has attracted substantial media attention. If, as appears likely, it proves possible to "humanize" animal organs and evade the problems of rejection, in the coming few years there will be a tremendous increase in this procedure, mostly using organs from animals specially grown for their harvestable organs. This book will lay out the potential and promise of the technique, the history of organ transplantation, the technical problems and breakthroughs in overcoming immune rejection, and typing and humanizing donor organs for transplantation. The ethical questions about growing animals specifically for organ harvest, and the substantial public health concern from the certainty that animal viruses will be passaged into humans with the donated organs, will be fully discussed. The authors are among the leaders of the field of xenotransplantation.

About the Author

David Cooper, MD, is an Immunologist at the Transplantation Biology Research Center, Massachusetts General Hospital, and an Associate Professor of Surgery at Harvard Medical School. Robert Lanza, MD, is Senior Director of Tissue Engineering and Transplant Medicine, Advanced Cell Technology, Inc.

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