The zebrafish model organism is an important tool used to study normal developmental biology, genetic diseases and the influences of environmental toxins. New biotechnologies are being applied to the model system to elucidate biological and pathophysiological mechanisms. The zebrafish model is used to study various cellular, physiological and system biology problems. The zebrafish has various advantages for study, as the organism is simpler than that of most other vertebrates; however, there is also a high degree of conservation with the other vertebrates. This Special Issue of Biomedicines, entitled "Zebrafish Models in Development and Disease", highlights the extraordinary capabilities of the model that can help us to understand biological complexity in a normal or diseased state. The model will continue to grow and contribute to biomedical knowledge in the future.

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