The application of gene expression profiling to clinical breast cancer research

Sherene Loi

ISBN 10: 3838329732 ISBN 13: 9783838329734

Published by LAP LAMBERT Academic Publishing, 2014

Language: English

Condition: New Soft cover

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Bibliographic Details

Title

The application of gene expression profiling to clinical breast cancer research

Publisher

LAP LAMBERT Academic Publishing

Publication Date

2014

Language

English

ISBN 10

3838329732

ISBN 13

9783838329734

Binding

Taschenbuch

Condition

Neu

Dimensions

Weight

435 grams

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B�cher

About this title

Synopsis

The book has three main results parts. Chapter 3 illustrates the first independent validation study of a 70-gene signature developed from gene expression profiling for use in breast cancer prognosis and demonstration of its ability to add independent prognostic information to the clinical prognostic factors currently used. The successful validation of this study preceded the design and implementation of a world-wide randomized clinical trial evaluating the gene signature’s clinical utility. This trial has commenced and is currently recruiting in Europe. Chapter 4 describes the finding that proliferation-related genes can predict clinical outcome consistently in breast cancer and many gene signatures developed for predicting breast cancer prognosis derive a significant proportion of their prognostic power from these genes. Finally, chapter 5 describes the use of proliferation-related genes to define two distinct prognostic molecular subgroups within estrogen receptor positive breast cancers.

About the Author

MBBS, FRACP, Degree of Doctor of Philosophy, December 2007.

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