John D. Clough, M.D. was born in northwestern Iowa and grew up in Des Moines, Iowa; Augusta, Maine; and Silver Spring, Maryland. He received BS and MD degrees from George Washington University and in 1965 went to Cleveland Clinic to begin his postgraduate training in internal medicine. In 1967 he returned to suburban Maryland and began a three-year term as a commissioned officer in the U.S. Public Health Service at the National Institutes of Health. There he pusued studies in immunology in the metabolism branch of the National Cancer Institute under the direction of Dr. Warren Strober.
In 1970 he returned to Cleveland Clinic to complete his postgraduate training and joined the rheumatology department as a staff member in 1971. He started the Special Immunnology Laboratory for the investigation of autoimmune disorders in 1972 and headed this laboratory until 1990. He was appointed chairman of the Department of Rheumatic and Immunologic Diseases in 1970, a post that he also held until 1990. He was appointed executive director of the Division of Health Affairs at the Cleveland Clinic in 1990, an administrative post that he held until 2004. He left that position to become publisher of the Cleveland Clinic Press, a position that he held until his retirement at the end of 2007.
Dr. Clough is a fellow of the American College of Physicians and of the American College of Rheumatology. He is a past chairman of the Ohio Public Health Council. He is married to pediatrician Mary L. Clough, and they have three children and eight grandchildren. He lives in Gates Mills, Ohio.