Sunil Kumar Kadiri (58 results)

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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book offers a detailed exploration of G-protein-coupled receptors (GPCRs), key membrane proteins that mediate cellular responses to diverse signals. It covers GPCR activation, regulation, structural advances, technological innovations, and drug discovery, emphasizing their crucial roles in physiology and therapy. By integrating molecular insights with clinical applications, the book bridges basic science and translational research in GPCR biology.GPCRs function as vital cellular communication hubs by activating guanine nucleotide-binding proteins (G proteins) to transduce extracellular signals into intricate intracellular pathways. These signaling cascades regulate processes such as cell growth, gene expression, and intercellular communication, crucial for maintaining cellular homeostasis. Disruptions in GPCR signaling are linked to diverse pathologies, making them prime targets for therapeutic intervention.The book begins with GPCR structure and activation mechanisms, followed by signaling networks and receptor regulation. It then covers breakthroughs in structural biology and cutting-edge research technologies. Drug discovery strategies, including allosterism and biased signaling, are explored next. Systems biology and molecular pathologies provide deeper insights into GPCR functions and diseases. The final chapters focus on cellular toxicity, preclinical to clinical drug development, and future research challenges.This resource is designed for researchers and scientists in molecular pharmacology, cell biology, and drug discovery, as well as graduate and postgraduate students. Pharmaceutical industry professionals, educators, trainees, and healthcare professionals engaged in GPCR-targeted therapies will also find this book an essential guide to the latest advances and clinical applications. …

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Gebundene Ausgabe. Condition: Neu. This book offers a detailed exploration of G-protein-coupled receptors (GPCRs), key membrane proteins that mediate cellular responses to diverse signals. It covers GPCR activation, regulation, structural advances, technological innovations, and drug discovery, emphasizing their crucial roles in physiology and therapy. By integrating molecular insights with clinical applications, the book bridges basic science and translational research in GPCR biology.GPCRs function as vital cellular communication hubs by activating guanine nucleotide-binding proteins (G proteins) to transduce extracellular signals into intricate intracellular pathways. These signaling cascades regulate processes such as cell growth, gene expression, and intercellular communication, crucial for maintaining cellular homeostasis. Disruptions in GPCR signaling are linked to diverse pathologies, making them prime targets for therapeutic intervention.The book begins with GPCR structure and activation mechanisms, followed by signaling networks and receptor regulation. It then covers breakthroughs in structural biology and cutting-edge research technologies. Drug discovery strategies, including allosterism and biased signaling, are explored next. Systems biology and molecular pathologies provide deeper insights into GPCR functions and diseases. The final chapters focus on cellular toxicity, preclinical to clinical drug development, and future research challenges.This resource is designed for researchers and scientists in molecular pharmacology, cell biology, and drug discovery, as well as graduate and postgraduate students. Pharmaceutical industry professionals, educators, trainees, and healthcare professionals engaged in GPCR-targeted therapies will also find this book an essential guide to the latest advances and clinical applications. Sprache: Englisch Gewicht in Gramm: 741. …

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Gebundene Ausgabe. Condition: Neu. As research continues to uncover the complex causes of Alzheimer's disease, a deeper understanding of its cellular and molecular mechanisms is essential for developing effective therapies. Cellular and Molecular Mechanisms in Alzheimer's Disease Therapeutics, a two volume set, provides a comprehensive examination of the processes driving disease onset and progression, bringing together leading experts to illuminate key pathways, therapeutic targets, and emerging treatment strategies. Volume 1: Cellular Mechanisms explores the cellular mechanisms underlying Alzheimer's disease-such as synaptic dysfunction, neuroinflammation, mitochondrial impairment, and protein aggregation-while highlighting their therapeutic implications, including personalized medicine, blood-brain barrier dynamics, and micro RNA-based approaches. Volume 2: Molecular Mechanisms examines AD at the molecular level-covering protein aggregation, cellular dysfunction, and neuroinflammation-while integrating emerging therapies, personalized approaches, and global research efforts to bridge fundamental mechanisms with clinical applications. Sprache: Englisch Gewicht in Gramm: 599.…

Gebundene Ausgabe. Condition: Neu. As research continues to uncover the complex causes of Alzheimer's disease, a deeper understanding of its cellular and molecular mechanisms is essential for developing effective therapies. Cellular and Molecular Mechanisms in Alzheimer's Disease Therapeutics, a two volume set, provides a comprehensive examination of the processes driving disease onset and progression, bringing together leading experts to illuminate key pathways, therapeutic targets, and emerging treatment strategies. Volume 1: Cellular Mechanisms explores the cellular mechanisms underlying Alzheimer's disease-such as synaptic dysfunction, neuroinflammation, mitochondrial impairment, and protein aggregation-while highlighting their therapeutic implications, including personalized medicine, blood-brain barrier dynamics, and micro RNA-based approaches. Volume 2: Molecular Mechanisms examines AD at the molecular level-covering protein aggregation, cellular dysfunction, and neuroinflammation-while integrating emerging therapies, personalized approaches, and global research efforts to bridge fundamental mechanisms with clinical applications. Sprache: Englisch Gewicht in Gramm: 644.…

Hardback. Condition: New. Discover a groundbreaking path forward in the fight against dementia with this vital resource, which bridges the gap between costly drug discovery and the transformative potential of harnessing the immune system to finally target the underlying mechanisms of Alzheimer's disease. Alzheimer's disease, which is characterized by a progressive loss of memory and cognitive function, is the most prevalent type of dementia in adults. Despite being widespread, there is currently no permanent treatment for this condition. Current drugs provide only symptomatic relief with serious adverse consequences. The process of discovering new medications in this field is costly and time-consuming, so despite effort on the part of the scientific and pharmaceutical communities, few Alzheimer's medications have been created. This book offers a comprehensive exploration of how the immune system can be harnessed to combat one of the most challenging neurodegenerative disorders of our time. It examines the scientific foundations of immunotherapy, including antibody-based strategies, vaccine development, and modulation of innate and adaptive immune responses. It highlights the interplay between amyloid and tau pathology, neuroinflammation, and microglial activation, providing readers with a clear understanding of the mechanisms driving therapeutic innovation. Beyond the laboratory, this volume bridges preclinical research with clinical applications, addressing safety, efficacy, and regulatory considerations. Case studies, emerging technologies, and future directions are presented to illustrate both the promise and the challenges of immunotherapy in Alzheimer's care. Designed for neuroscientists, pharmacologists, clinicians, and biotechnology professionals, the book serves as a vital resource for those seeking evidence-based insights into cutting-edge therapeutic approaches that may transform the landscape of Alzheimer's treatment.…

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Hardback. Condition: New. Discover a groundbreaking path forward in the fight against dementia with this vital resource, which bridges the gap between costly drug discovery and the transformative potential of harnessing the immune system to finally target the underlying mechanisms of Alzheimer's disease. Alzheimer's disease, which is characterized by a progressive loss of memory and cognitive function, is the most prevalent type of dementia in adults. Despite being widespread, there is currently no permanent treatment for this condition. Current drugs provide only symptomatic relief with serious adverse consequences. The process of discovering new medications in this field is costly and time-consuming, so despite effort on the part of the scientific and pharmaceutical communities, few Alzheimer's medications have been created. This book offers a comprehensive exploration of how the immune system can be harnessed to combat one of the most challenging neurodegenerative disorders of our time. It examines the scientific foundations of immunotherapy, including antibody-based strategies, vaccine development, and modulation of innate and adaptive immune responses. It highlights the interplay between amyloid and tau pathology, neuroinflammation, and microglial activation, providing readers with a clear understanding of the mechanisms driving therapeutic innovation. Beyond the laboratory, this volume bridges preclinical research with clinical applications, addressing safety, efficacy, and regulatory considerations. Case studies, emerging technologies, and future directions are presented to illustrate both the promise and the challenges of immunotherapy in Alzheimer's care. Designed for neuroscientists, pharmacologists, clinicians, and biotechnology professionals, the book serves as a vital resource for those seeking evidence-based insights into cutting-edge therapeutic approaches that may transform the landscape of Alzheimer's treatment.…

Hardcover. Condition: Brand New. 352 pages. 9.25x6.22x1.61 inches. In Stock.

Condition: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…

Gebundene Ausgabe. Condition: Neu. Neurodegenerative disorders pose a significant global health challenge, affecting millions of individuals and placing immense strain on families, healthcare systems, and economies. Advancements in understanding the underlying molecular mechanisms have opened new avenues for early diagnosis and targeted therapies. Innovative treatments like enzyme replacement and gene-editing technologies offer promising potential to slow disease progression and improve quality of life. These scientific breakthroughs not only enhance clinical care but also catalyze interdisciplinary collaboration across research, medicine, and policy. As society confronts aging populations and increasing neurological conditions, continued innovation in this field is crucial for sustainable, compassionate healthcare solutions. Recent Breakthroughs in Neurodegenerative Disorders and Enzyme Therapy explores molecular mechanisms, diagnostic, strategies, and therapeutic advancements for neurodegenerative conditions. Designed to bridge basic science and clinical applications, this book examines the role of lysosomal enzymes, advancements in gene-editing for enzyme delivery, and the translation of lab findings into real-world therapies. Covering topics such as artificial intelligence, neuroimaging, and radiation, this book is an excellent resource for neuroscientists, clinicians, medical researchers, biochemists, and more. Sprache: Englisch Gewicht in Gramm: 1086.…

Condition: New. 2026. 1st Edition. hardcover. . . . . . Books ship from the US and Ireland.

Condition: New. 2026. 1st Edition. hardcover. . . . . .

PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.

Paperback. Condition: new. Paperback. Brain Tumour Drug Development provides a clear, multidisciplinary update on modern therapies for glioblastoma and other aggressive brain tumours. The book focuses on improving drug precision, crossing the blood-brain barrier, identifying biomarkers, designing effective trials, and accelerating translation from research to real patient care. Key Features: -Overcomes the blood-brain barrier using advanced delivery methods.-Improves drug penetration & specificity with nano and polymer-based systems.-Explores new therapies through immunotherapy, gene therapy, and personalised medicine.-Builds preclinical models & identifies biomarkers to support clinical success.-Designs regulatory-aligned clinical trial strategies for faster translation. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.…