Crick Watson (28 results)

Soft cover. Condition: Very Good. 128 pages. Illustrated. Andrew M Wilson, Juliet A Vickery and Stephen J Browne "Numbers and distribution of Northern Lapwings Vanellus vanellus breeding in England and Wales in 1998" / David Jenkins and Adam Watson "Bird numbers in relation to grazing on a grouse moor from 1957-61 to 1988-98" / Michael P Toms, Numphrey Q P Crick and Colin R Shawyer "The status of breeding Barn Owls Tyto alba in the United Kingdom 1995-97" / Roger Johansen, Robert T Barrett and Torstein Pedersen "Foraging strategies of great Cormorants Phalacrocorax carbo carbo wintering north of the Arctic Circle".

Soft cover. Condition: Near Fine. 1st Edition. First edition. 8vo. pp. 187; ports. of nobel prize winners, illusts.; fine in original printed card wrappers. Crick, Watson and Wilkins collectively received the Nobel Prize for Physiology and Medicine for 1962. Their prize speeches are reproduced in the present volume: respectively 'On the Genetic Code', 'The Involvement of RNA in the Synthesis of Proteins', and 'The Molecular Configuration of Nucleic Acids'. Other winners this year were Max Perutz for work on crystalline proteins, and John Steinbeck for literature.

Condition: Very Good. Prompt Shipment, shipped in Boxes, Tracking PROVIDEDVery important publication. Symposia has presented many discoveries, such as the structure of DNA, the genetic code, the polymerase chain reaction (PCR), and RNA interference (RNAi)-Featuring the important: Volume XVIII (1953) Watson and Crick DNA (this copy inscribed presentation copy signed by Milislav Demerec who was head of the Laboratory. The recipient was a professor at Cornell.Inluding: XIII (1948), XXVI (1961), XII (1947), X (1942), XI (1946), , XXII (1957), XVII (1952), XXI (1956), XXVIII (1963) Small gouge front cover, IX (1941), XIV (1949), XV (1950) ex-library with few stamps and spine ID letters in white, XL (1975), XXVI (1961), XXVII (1962), XVI (1951), XXIII (1958)Most are in very good condition. Some have the prior owners name, one has a ring stain on cover. A very serviceable group of volumes. Some spine letters darkened, or spine sunned. Biology. Genetics. *Provenance: William B. Provine.

Hardcover. Condition: Very Good. Dust Jacket Condition: Very Good. 1st Edition. Scarce, three-hardback set copyright 1964-1967; each VG in VG dj; remarkably well preserved withdrawal from college library with usual stamps and stickers; text block and boards tight and square; dj preserved in clear archival jacket; due to weight of this set expedited and international orders will require extra freight charges 3-BNB-top.

Hardcover with Dust Jacket. First Printing. First printing with the review slip laid in. Blue cloth with light sunning to the top edge, in a near fine dust jacket. 226pps plus index, Red Cloth.

First edition, complete volume, signed by Crick on the first paper; 8vo (24.5 x 17 cm); illustrations throughout the text, 1982 ownership inscription of J.D. Mollon to front pastedown, spotting to early and late leaves; contemporary green library cloth, titles to spine gilt, red speckled edges, corners bumped and worn, a little wear at the ends of the spine, lower joint just starting, very good condition; 1168pp, 64 page index. First edition, the complete journal volume containing the first four papers on the structure of DNA, signed by Crick on the 'Molecular Structure of Nucleic Acids' paper. From the library of John D. Mollon, eminent professor of visual neuroscience at Cambridge.

Hardcover. Condition: VG+. Crick & Franklin & Watson & Wilkins / 1953 and 1961 / [Breakthroughs in genetics, signed by Crick] Nature: A Weekly Journal of Science. Vol. 171 (January 3, 1953 to June 27, 1953), Vol. 172 (July 4, 1953 to December 26, 1953), Vol. 192 (October 7, 1961 to December 30, 1961) (Safe 4, 103492) Quarto. Three volumes, each bound in blue cloth with label to spine. Occasional fingersoiling and pencil marginalia. Light foxing to block edges of Vol. 172. Vol. 171 with inked and embossed stamps of Naval Research Laboratory Library to title page. Tape repair to 1181/82 of Vol. 172. Signed by Crick at first page of each of three articles he co-authored (twice in Vol. 171, once in Vol. 192). Housed in blue cloth slipcase. Vol. 171: [ii], 1168, iii-llxiv. Vol. 172: lxxi, [1], 1200 pp. Vol. 192: cvii, [cviii, blank], xiv-xvi, 50, xvii-xxx, 51-70, xxxi-xxxii, 71-94, lxi-lxiv, 95-112, lxv-lxxx, 113-194, cvii-cxxii, 195-292, clv-clxxii, 293-372, clxxii-clxxiv, 373-386, cciii-ccxxii, 387-484, ccxlvii-cclxv, 485-586, cclxxxix-cccviii, 587-688, cccxxxiii-cccl, 689-784, ccclxxxi-ccccxviii, 785-989, ccccxli-ccccxlviii, 899-1002, cccclxxxiii-dii, 1003-1104, dxxi-dxxxii, 1105-1218, dliii-dlxxii, 1219-1322 Volume 171 J.D.Watson and F.H.C. Crick, "Molecular Structure of Nucleic Acids A Structure for Deoxyribose Nucleic Acid", 737 J.D.Watson and F.H.C. Crick, "Genetical Implications of the Structure of Deoxyribonucleic Acid", 964 Rosalind E. Franklin and R. G. Gosling, "Molecular Structure of Nucleic Acids Molecular Configuration in Sodium Thrymonucleate", 740 M.H.F. Wilkins, A.R. Stokes & H.R. Wilson, "Molecular Structure of Deoxypentose Nucleic Acids", 738 Volume 172 Rosalind E. Franklin and R. G. Gosling, "Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate", 156 M.H.F. Wilkins, W.E. Seeds & A. R. Stokes, H.R. Wilson, "Helical Structure of Crystalline Deoxypentose Nucleic Acid", 759 Volume 192 F.H.C. Crick, Leslie Barnett, S. Brenner, R.J. Watts-Tobin, "General Nature of the Genetic Code for Proteins", 1227. Book.

First edition of Watson and Crickâs classic work on Virus Structure. Octavo, original cloth. Boldly signed by James Watson on the front free endpaper. Fine in a very good dust jacket. Rare and desirable signed. Presented as the first paper at the prestigious 1956 Ciba Foundation. symposium and the first paper in this collection, this seminal workâ" their "last direct collaboration" (Ridley)â"revealed Watson and Crickâs theory of virus structure, a "great success" (Judson, 316).

First edition of this riveting work on the legendary scientist James D. Watson. Octavo, original boards. Boldly signed by James Watson and Francis Crick on the half-title page. Fine in a fine dust jacket. Jacket design by Ron Monteleone. Rare and desirable signed by Watson and Crick. In its drama, Watson's life has rivaled the discovery of the structure of DNA. So intent on his research was this awkward, bumbling scholar that he would climb a drainpipe to sneak into a lab at night. Watson had a knack for selecting problems that would yield important scientific results, but did he pilfer? Did Rosalind Franklin originate crucial material? If so, why was she not included in the Nobel Prize? Baldwin, who had exceptional access to Watson and his family, conveys the elegance of science (the ``structure [of DNA] was too pretty not to be true''), describes diverse influences (birding, Arrowsmith, movies), and even gives advice (go to a college where others are brighter than you, to test your mettle). Voluminous detail on what, exactly, provided a lifetime's worth of inspiration broaden an intriguing picture of this intrepid competitor.

First edition of Watson's ground breaking work regarding the discovery of DNA for which the author, Francis Crick and Maurice Wilkins were awarded the Nobel Prize in Medicine in 1962. Signed by both James Watson and Francis Crick on the title page. Lengthily signed with a quote written by Watson on the half-title page, "I think people are born curious and too often have it pounded out of their spirit." Octavo, original blue cloth, with numerous diagrams and photographic illustrations. Fine in a fine dust jacket. Jacket design by Jeanyee Wong. Foreword by Sir Lawrence Bragg. ÂHoused in a custom half morocco clamshell box by the Harcourt Bindery. A unique example, most rare and desirable with a lengthy quote from the co-discover of DNA. "Science seldom proceeds in the straightforward logical manner imagined by outsiders," writes James Watson in The Double Helix, his account of his codiscovery (along with Francis Crick) of the structure of DNA. Watson, Crick and Maurice Wilkins won Nobel Prizes for their work, and their names are memorized by biology students around the world. But as in all of history, the real story behind the deceptively simple outcome was messy, intense, and sometimes truly hilarious. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "One of the investigators, more than any of the others, realized the decisive importance of the DNA molecules in biology, and it was this understanding which urged him relentlessly to push this work toward a successful conclusion, in spite of his rather modest technical qualifications for this task" (Mayr, 823). "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).

Hardcover. Condition: Very Good. Dust Jacket Included. 1 leaf, xvi, 226 pp; illus. Original cloth. Swedish postage stamp honoring Crick, Watson, and Wilkins for the Nobel Prize in 1962 is pasted to title page. Wilkins's inscription is partly on the stamp. Very Good, in dust jacket. Third Impression of British Edition. The following pages are signed or annotated: 1. Title page: SIGNED BY NOBEL LAUREATES JAMES D. WATSON, FRANCIS CRICK, MAURICE WILKINS ("with best wishes/ Maurice Wilkins/ April 2003"), AND BY RAYMOND GOSLING. 2. p. 214: SIGNED BY FRANCIS CRICK AND JAMES D. WATSON UNDER THE PHOTOGRAPH SHOWING THEM STANDING BY THEIR DNA MODEL (opposite p. 214). 3. p. 18 SIGNED BY MAURICE WILKINS UNDER HIS PHOTOGRAPH (opposite p. 18). 4. Annotated by Raymond G. Gosling about Rosalind Franklin (under her photograph opposite p. 70): "She had wonderfully lustrous dark eyes. I found her very attractive, as did most everyone who worked with her. She had a strong personality and did not suffer fools gladly. Her powers of concentration were quite fierce and she could get done in a day what other people might have taken several to achieve. Raymond Gosling Sept. 2003". 5. Annotated by Raymond G. Gosling about X-ray photograph of crystalline DNA in the A form (under photograph opposite p. 72): "The pattern that 'kick started' the whole story. A multifibre (about 35) specimen made by Wilkins & myself and taken on a conventional Rayniax tube in the basement of King s College London. This pattern was one shewn by Maurice at the Naples meeting. The A form was obtained serendipitously by my regulating the Hydrogen into the camera by bubbling thru' water--hence ~92% RH. Raymond Gosling. Sept. 2003." 6. Annotated by Raymond G. Gosling about X-ray photograph of DNA in the B form, taken by Rosalind Franklin late in 1952 (under photograph opposite p. 169): "As Rosalind's assistant I actually 'took' this X-ray pattern. Since we were working closely together the overall strategy was Rosalind's. Therefore the importance attributed to some--as to who 'took' the photograph--is inappropriate. R G Gosling Sept. 2003." NOTE: I have included photos of everything signed or annotated, except for Maurice Wilkins's signature under his photo (opposite p. 18). I have a photo of that signature, too, which I will supply on request, but ABE allows only 5 photos per listing. Signed by Author(s).

Hardcover. Condition: Very Good. 1st Edition. x, 320 pp; illus. Original laminated boards. Spine worn, else Very Good. First Edition. SIGNED, TWICE (AND DIFFERENTLY), BY JAMES WATSON TO FRANCIS CRICK. In back, upside down, on the rear flyleaf, Watson has written: "for Francis with the faint hope/ that he will abandon the vertebrate brain/ Jim/ Kyoto ___?/ December 1981". In front on the front flyleaf, Watson has written: "for Francis/ with the mild? hope that/ you might realize that vision and vertebrates/ might be biting off too much/ Jim/ Kyoto ___?/ 1981". With the ink name stamp "Prof. F. H. C. Crick" on the front flyleaf. Acknowledgment of the editors (p. vii): "We thank James D. Watson for proposing the idea of this book to us; year by year, his unfailing support and enthusiasm for the leech neurobiology course has provided an opportunity for contact among investigators working on the leech, for exchanging ideas and jointly developing new techniques.". Signed by Author(s).

First edition of this collection of Nobel Lectures in physiology or medicine from the years 1942-1962. Thick Octavo, original yellow cloth. Signed by all three Nobel Prize-winning scientists Francis Crick, James D. Watson and Maurice Wilkins on the title page. They were awarded the Nobel Prize in Medicine in 1962, "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material."Fine in a very good dust jacket with some closed tears and toning to the spine. An exceptional piece signed by these Nobel Prize-winning scientists. In the early 1950s, the race to discover DNA was on. At Cambridge University, graduate student Francis Crick and research fellow James Watson had become interested, impressed especially by Pauling's work. Meanwhile at King's College in London, Maurice Wilkins (b. 1916) and Rosalind Franklin were also studying DNA. The Cambridge team's approach was to make physical models to narrow down the possibilities and eventually create an accurate picture of the molecule. The King's team took an experimental approach, looking particularly at x-ray diffraction images of DNA. Watson and Crick took a crucial conceptual step, suggesting the molecule was made of two chains of nucleotides, each in a helix as Franklin had found, but one going up and the other going down. Crick had just learned of Chargaff's findings about base pairs in the summer of 1952. He added that to the model, so that matching base pairs interlocked in the middle of the double helix to keep the distance between the chains constant. Watson and Crick showed that each strand of the DNA molecule was a template for the other. During cell division the two strands separate and on each strand a new "other half" is built, just like the one before. This way DNA can reproduce itself without changing its structure -- except for occasional errors, or mutations. The structure so perfectly fit the experimental data that it was almost immediately accepted. DNA's discovery has been called the most important biological work of the last 100 years, and the field it opened may be the scientific frontier for the next 100.

First edition of the collected speeches of the 52nd Cold Spring Harbor Symposia on Quantitative Biology. Foreword by James D. Watson. Quarto, original red cloth, illustrated with photographs, diagrams. Association copy, inscribed by James Watson to Francis Crick on the front free endpaper, "For Francis, the first of us to think sensibly as to what the Central Dogma tells us about the origin of life, from Jim, upon the 35th anniversary of the Double Helix. April 10, 1988." Also signed by Francis Crick. A unique piece of history between arguably the two most influential scientists of the twentieth century, co-discoverers of the structure of DNA. In near fine condition. Housed in a custom slipcase. An exceptional association linking the discoverers of the molecular structure of DNA. Participants of the 52nd Symposia on Quantitative Biology included James D. Watson, James Darnell, Peter Moore, Raul Saavedra, and Fusao Tomita, each of whom spoke on a wide range of topics related to the discovery, structure and informational properties of RNA. Watson made his first trip to Cold Spring Harbor in 1948 at the age of 20, he returned 5 years later to make his seminal presentation reporting the discovery of DNA, for which he and Francis Crick would be awarded the Nobel Prize. Watson's "second act" commenced in 1968, when, following the publication of The Double Helix, he became the laboratory's Director. During his tenure, he transformed CSHL from an institution suffering from a lack of funding into one of the world's primary biomedical research centers.

First edition of Watson's ground breaking work regarding the discovery of DNA for which the author, Francis Crick and Maurice Wilkins were awarded the Nobel Prize in Medicine in 1962.ÂOctavo, original cloth, illustrated with 19 half-tone illustrations and 11 diagrams. Signed by both James D. Watson and Francis Crick on the title page. Very good in an excellent dust jacket with some light rubbing to the spine crown. Jacket design by Dorothy Judd. Foreword by Sir Lawrence Bragg. Rare signed by both Watson and Crick. "Science seldom proceeds in the straightforward logical manner imagined by outsiders," writes James Watson in The Double Helix, his account of his codiscovery (along with Francis Crick) of the structure of DNA. Watson, Crick and Maurice Wilkins won Nobel Prizes for their work, and their names are memorized by biology students around the world. But as in all of history, the real story behind the deceptively simple outcome was messy, intense, and sometimes truly hilarious. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "One of the investigators, more than any of the others, realized the decisive importance of the DNA molecules in biology, and it was this understanding which urged him relentlessly to push this work toward a successful conclusion, in spite of his rather modest technical qualifications for this task" (Mayr, 823). "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).

Soft cover. Condition: Very Good. 2 leaves, 364 pp (printed on both sides of each page). Spiral-bound. The front cover is a clear plastic. The rear cover is a black paper. Very Good. SIGNED BY JAMES WATSON TO FRANCIS CRICK: "For Francis/ from/ Jim/ 17 January 2003." (see photos) "Copyright 2002 by J. D. Watson. Not to be reprinted without permission.". Signed by Author(s).

xii, 292pp. 8vo. Condition: Green cloth. Fine. First Edition. First Edition. xii, 292pp. 8vo. Crick and Watson's article is the first in this collection "Virus Structure: General Principles" at pp.5-13.

First edition. The Double Helix Signed by All But One. First edition, offprint, signed by Watson, Crick, Wilkins, Gosling, Stokes & Wilson, i.e. six of the seven authors. We know of no copy signed by Franklin, and strongly doubt that any such copy exists. Furthermore this copy is, what we believe to be, just one of three copies signed by six authors. One of the most important scientific papers of the twentieth century, which ?records the discovery of the molecular structure of deoxyribonucleic acid (DNA), the main component of chromosomes and the material that transfers genetic characteristics in all life forms. Publication of this paper initiated the science of molecular biology. Forty years after Watson and Crick?s discovery, so much of the basic understanding of medicine and disease has advanced to the molecular level that their paper may be considered the most significant single contribution to biology and medicine in the twentieth century? (One Hundred Books Famous in Medicine, p. 362). ?The discovery in 1953 of the double helix, the twisted-ladder structure of deoxyribonucleic acid (DNA), by James Watson and Francis Crick marked a milestone in the history of science and gave rise to modern molecular biology, which is largely concerned with understanding how genes control the chemical processes within cells. In short order, their discovery yielded ground-breaking insights into the genetic code and protein synthesis. During the 1970s and 1980s, it helped to produce new and powerful scientific techniques, specifically recombinant DNA research, genetic engineering, rapid gene sequencing, and monoclonal antibodies, techniques on which today?s multi-billion dollar biotechnology industry is founded. Major current advances in science, namely genetic fingerprinting and modern forensics, the mapping of the human genome, and the promise, yet unfulfilled, of gene therapy, all have their origins in Watson and Crick?s inspired work. The double helix has not only reshaped biology, it has become a cultural icon, represented in sculpture, visual art, jewelry, and toys? (Francis Crick Papers, National Library of Medicine, profiles./SC/Views/Exhibit/narrative/). In 1962, Watson, Crick, and Wilkins shared the Nobel Prize in Physiology or Medicine ?for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material.? This copy is signed by all the authors except Rosalind Franklin (1920 ?1958) - we have never seen or heard of a copy signed by her. In 1869, the Swiss physiological chemist Friedrich Miescher (1844-95) first identified what he called ?nuclein? inside the nuclei of human white blood cells. (The term ?nuclein? was later changed to ?nucleic acid? and eventually to ?deoxyribonucleic acid,? or ?DNA.?) Miescher?s plan was to isolate and characterize not the nuclein (which nobody at that time realized existed) but instead the protein components of leukocytes (white blood cells). Miescher thus made arrangements for a local surgical clinic to send him used, pus-coated patient bandages; once he received the bandages, he planned to wash them, filter out the leukocytes, and extract and identify the various proteins within the white blood cells. But when he came across a substance from the cell nuclei that had chemical properties unlike any protein, including a much higher phosphorous content and resistance to proteolysis (protein digestion), Miescher realized that he had discovered a new substance. Sensing the importance of his findings, Miescher wrote, ?It seems probable to me that a whole family of such slightly varying phosphorous-containing substances will appear, as a group of nucleins, equivalent to proteins? But Miescher?s discovery of nucleic acids was not appreciated by the scientific community, and his name had fallen into obscurity by the 20th century. ?Researchers working on DNA in the early 1950s used the term ?gene? to mean the smallest unit of genetic information, but they did not know what a gene actually looked like structurally and chemically, or how it was copied, with very few errors, generation after generation. In 1944, Oswald Avery had shown that DNA was the ?transforming principle,? the carrier of hereditary information, in pneumococcal bacteria. Nevertheless, many scientists continued to believe that DNA had a structure too uniform and simple to store genetic information for making complex living organisms. The genetic material, they reasoned, must consist of proteins, much more diverse and intricate molecules known to perform a multitude of biological functions in the cell. ?Crick and Watson recognized, at an early stage in their careers, that gaining a detailed knowledge of the three-dimensional configuration of the gene was the central problem in molecular biology. Without such knowledge, heredity and reproduction could not be understood. They seized on this problem during their very first encounter, in the summer of 1951, and pursued it with single-minded focus over the course of the next eighteen months. This meant taking on the arduous intellectual task of immersing themselves in all the fields of science involved: genetics, biochemistry, chemistry, physical chemistry, and X-ray crystallography. Drawing on the experimental results of others (they conducted no DNA experiments of their own), taking advantage of their complementary scientific backgrounds in physics and X-ray crystallography (Crick) and viral and bacterial genetics (Watson), and relying on their brilliant intuition, persistence, and luck, the two showed that DNA had a structure sufficiently complex and yet elegantly simple enough to be the master molecule of life. ?Other researchers had made important but seemingly unconnected findings about the composition of DNA; it fell to Watson and Crick to unify these disparate findings into a coherent theory of genetic transfer. The organic chemist Alexander Todd had determined that the backbone of the DNA molecu. Signed.

First Edition. Offprint, 8vo (210 x 140mm), pp. 14, with two diagrams (including the double helix) and two illustrations from photographs. The three-paper offprint issue, of the primary record of the co-discovery of the molecular structure of DNA, the most transformative moment in twentieth-century biology. Stapled in self-wrappers as issued. Signed by Maurice Wilkins on the first page. Very lightly toned and a coulpe soft creases, near fine. Grolier Club, One Hundred Books Famous in Medicine, 99; Dibner, Heralds of Science, 200. Garrison-Morton 256.3; Judson, Eighth Day of Creation, pp. 145-56. Ex-Dr. Myron Printzmetal. The discovery of DNA's double helix structure emerged from an intense period of competitive collaboration between research teams at Cambridge and King's College London. Watson and Crick's theoretical breakthrough synthesized crucial experimental evidence from multiple sources: Erwin Chargaff's base composition rules demonstrating the 1:1 ratio of adenine to thymine and guanine to cytosine, X-ray crystallographic data revealing DNA's helical structure, and most critically, the precise measurements of backbone positioning and molecular dimensions. Their elegant model proposed complementary base pairing (A-T and C-G) held together by hydrogen bonds, immediately suggesting a mechanism for genetic replication where each strand could serve as a template for its complement. The accompanying papers by Wilkins, Stokes, and Wilson, and by Franklin and Gosling, provided essential experimental validation through X-ray diffraction analysis, creating a unified presentation of both theoretical insight and empirical evidence that established the foundation of molecular biology. The contentious history surrounding this discovery has generated enduring scholarly debate, particularly regarding the systematic marginalization of Rosalind Franklin's contributions. Franklin's meticulous X-ray crystallographic work, conducted with her graduate student Raymond Gosling, had independently determined many key structural features including the antiparallel orientation of DNA strands, the external positioning of phosphate groups, and precise helical parameters. Her famous "Photograph 51" provided definitive evidence of DNA's helical structure, while her systematic analysis of A-form and B-form DNA revealed critical dimensions that enabled Watson and Crick's model construction. As Brenda Maddox documents in "Rosalind Franklin: The Dark Lady of DNA," Franklin's data was shown to Watson and Crick without her knowledge through Maurice Wilkins, creating an ethical controversy that persists in discussions of scientific collaboration and gender bias. Franklin's death from ovarian cancer in 1958, four years before the Nobel Prize was awarded to Watson, Crick, and Wilkins, has intensified debates about recognition and the complex dynamics of mid-twentieth century scientific discovery, with many scholars arguing that her rigorous experimental approach was as fundamental to the breakthrough as the theoretical modeling that received greater acclaim. This publication represents the founding document of modern molecular biology, establishing the conceptual framework for understanding heredity, genetic replication, and the molecular basis of life itself. The discovery immediately suggested mechanisms for protein synthesis and genetic information transfer, creating the theoretical foundation for subsequent developments in genetic engineering, biotechnology, and genomic medicine. As Francis Crick later observed, the structure's elegant simplicitywith its complementary base pairing and antiparallel strandsprovided not merely a static model but a dynamic mechanism explaining how genetic information could be accurately copied and transmitted across generations. The offprint's scientific significance extends far beyond its immediate discovery, representing the moment when biology transformed from a primarily descriptive science into a molecular discipline capable of manipulating the fundamental mechanisms of life, establishing the intellectual foundation for the biotechnology revolution that continues to reshape medicine, agriculture, and our understanding of evolutionary processes seventy years after its publication.

Soft cover. Condition: Near Fine. THE DISCOVERY OF THE STRUCTURE OF DNA, the cornerstone event in modern genetics and biology and one of the greatest scientific discoveries of all time. Signed by Francis Crick. This is the original announcement of the discovery of the double helix structure of DNA. It is accompanied by two important related papers on DNA, one by Wilkins, Stokes and Wilson, the other by Franklin and Gosling. In 1962 Watson, Crick, and Maurice Wilkins shared the Nobel Prize for medicine. It is very unusual to see this great paper in original state, as most of those that survive are now in bound volumes. Watson and Crick conclude the first paper with a classic understatement: The structure has novel features which are of considerable biological interest. . . . It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material. In 1962 Watson, Crick, and Maurice Wilkins shared the Nobel Prize for medicine. Offprint from: Nature 171, no. 4356 (April 25, 1953), 737-38. Original wrappers. Some foxing. Very good. Signed by Author(s).

First edition. DISCOVERY OF THE STRUCTURE OF DNA. First edition, in the rare offprint form, of one of the most important scientific papers of the twentieth century, which ?records the discovery of the molecular structure of deoxyribonucleic acid (DNA), the main component of chromosomes and the material that transfers genetic characteristics in all life forms. Publication of this paper initiated the science of molecular biology. Forty years after Watson and Crick?s discovery, so much of the basic understanding of medicine and disease has advanced to the molecular level that their paper may be considered the most significant single contribution to biology and medicine in the twentieth century? (One Hundred Books Famous in Medicine, p. 362). ?The discovery in 1953 of the double helix, the twisted-ladder structure of deoxyribonucleic acid (DNA), by James Watson and Francis Crick marked a milestone in the history of science and gave rise to modern molecular biology, which is largely concerned with understanding how genes control the chemical processes within cells. In short order, their discovery yielded ground-breaking insights into the genetic code and protein synthesis. During the 1970s and 1980s, it helped to produce new and powerful scientific techniques, specifically recombinant DNA research, genetic engineering, rapid gene sequencing, and monoclonal antibodies, techniques on which today?s multi-billion dollar biotechnology industry is founded. Major current advances in science, namely genetic fingerprinting and modern forensics, the mapping of the human genome, and the promise, yet unfulfilled, of gene therapy, all have their origins in Watson and Crick?s inspired work. The double helix has not only reshaped biology, it has become a cultural icon, represented in sculpture, visual art, jewelry, and toys? (Francis Crick Papers, National Library of Medicine, profiles./SC/Views/Exhibit/narrative/). In 1962, Watson, Crick, and Wilkins shared the Nobel Prize in Physiology or Medicine ?for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material.? In 1869, the Swiss physiological chemist Friedrich Miescher (1844-95) first identified what he called ?nuclein? inside the nuclei of human white blood cells. (The term ?nuclein? was later changed to ?nucleic acid? and eventually to ?deoxyribonucleic acid,? or ?DNA.?) Miescher?s plan was to isolate and characterize not the nuclein (which nobody at that time realized existed) but instead the protein components of leukocytes (white blood cells). Miescher thus made arrangements for a local surgical clinic to send him used, pus-coated patient bandages; once he received the bandages, he planned to wash them, filter out the leukocytes, and extract and identify the various proteins within the white blood cells. But when he came across a substance from the cell nuclei that had chemical properties unlike any protein, including a much higher phosphorous content and resistance to proteolysis (protein digestion), Miescher realized that he had discovered a new substance. Sensing the importance of his findings, Miescher wrote, ?It seems probable to me that a whole family of such slightly varying phosphorous-containing substances will appear, as a group of nucleins, equivalent to proteins? But Miescher?s discovery of nucleic acids was not appreciated by the scientific community, and his name had fallen into obscurity by the 20th century. ?Researchers working on DNA in the early 1950s used the term ?gene? to mean the smallest unit of genetic information, but they did not know what a gene actually looked like structurally and chemically, or how it was copied, with very few errors, generation after generation. In 1944, Oswald Avery had shown that DNA was the ?transforming principle,? the carrier of hereditary information, in pneumococcal bacteria. Nevertheless, many scientists continued to believe that DNA had a structure too uniform and simple to store genetic information for making complex living organisms. The genetic material, they reasoned, must consist of proteins, much more diverse and intricate molecules known to perform a multitude of biological functions in the cell. ?Crick and Watson recognized, at an early stage in their careers, that gaining a detailed knowledge of the three-dimensional configuration of the gene was the central problem in molecular biology. Without such knowledge, heredity and reproduction could not be understood. They seized on this problem during their very first encounter, in the summer of 1951, and pursued it with single-minded focus over the course of the next eighteen months. This meant taking on the arduous intellectual task of immersing themselves in all the fields of science involved: genetics, biochemistry, chemistry, physical chemistry, and X-ray crystallography. Drawing on the experimental results of others (they conducted no DNA experiments of their own), taking advantage of their complementary scientific backgrounds in physics and X-ray crystallography (Crick) and viral and bacterial genetics (Watson), and relying on their brilliant intuition, persistence, and luck, the two showed that DNA had a structure sufficiently complex and yet elegantly simple enough to be the master molecule of life. ?Other researchers had made important but seemingly unconnected findings about the composition of DNA; it fell to Watson and Crick to unify these disparate findings into a coherent theory of genetic transfer. The organic chemist Alexander Todd had determined that the backbone of the DNA molecule contained repeating phosphate and deoxyribose sugar groups. The biochemist Erwin Chargaff had found that while the amount of DNA and of its four types of bases ? the purine bases adenine (A) and guanine (G), and the pyrimidine bases cytosine (C) and thymine (T) ? varied widely from species to species, A and T always appeared in ratios of one-to-one, as did G and C. Maurice Wilkins and.

First edition, the three-paper offprint issue, of the primary record of the co-discovery of the molecular structure of DNA. This copy is from the library of Professor Hans Gustav Boman (1924-2008), the leading molecular biologist in Sweden; his signature is in ink on the first page. Three research groups independently investigated the structure of DNA in England in the early 1950s: Francis Crick and James Watson at the Cavendish Laboratory in Cambridge and two teams at King's College, London comprising Maurice Wilkins, Rosalind Franklin, Raymond Gosling, Alec Stokes, and Herbert Wilson. To acknowledge the simultaneity of the discovery, the directors of the respective institutions agreed that the three resulting papers would be published under the general title Molecular Structure of Nucleic Acids in the British scientific weekly Nature. Crick and Watson's paper, "A Structure for Deoxyribose Nucleic Acid", is illustrated with a schematic drawing by Odile Crick of the twisted-ladder structure of DNA, now famously known as the double helix. Wilkins, Stokes, and Wilson co-wrote "Molecular Structure of Deoxypentose Nucleic Acids", the second paper. Franklin and her research student Gosling submitted "Molecular Configuration in Sodium Thymonucleate", which features a half-tone illustration of Gosling's iconic X-ray "Photograph 51" of crystallized DNA. Franklin died four years before the Nobel Prize in Physiology or Medicine was awarded to Crick, Watson, and Wilkins in 1962 for their work on DNA, but without question her "contributions, and indeed her actual X-ray data, were crucial to the total achievement" (ODNB). "Two offprints exist of Watson and Crick's paper: a single sheet containing the Watson and Crick article only, and a fourteen-page pamphlet containing the papers of all three research groups. The pamphlet pages are smaller in size than the single leaf, which has the same dimensions as the leaves of the journal, and the layout is different, the single-leaf offprint being printed in two columns like the journal, the pamphlet in single-column pages. The page breaks are different in each of the two offprints and the journal, as is the placement of the illustrations relative to the text. Despite these differences, all three versions appear to have been printed from the same setting of type, except that in the two offprints one paragraph of text has been reset to accommodate the placement of the diagram of the DNA molecule" (Grolier, p. 363). Haskell F. Norman discusses the difficulty in establishing priority between the two formats in his introduction to One Hundred Books Famous in Medicine and closes by stating that "it is now our tentative conclusion that the three-paper offprint is the first issue" (p. xxi). Boman "was one of the pioneers in the field of molecular biology in Sweden" (Norrby, p. 11). After teaching at Uppsala University he transferred to Umeċ University to establish their microbiology department; under his leadership it became an international hub of research excellence. "Halfway through his career Boman moved on to Stockholm University and initiated a completely new line of research. It pioneered the development of insights into the emerging field of natural immunity. He developed this work in collaboration with Swedish colleagues and coined the term cecropines for this new kind of peptide antibiotics. This was a Nobel-class discovery" but - like Franklin - Boman died before he could see his research recognized as such (Norrby, p. 11). In 2011, his work formed the basis of a discovery by Jules Hoffman and Bruce Beutler, for which they received the Nobel Prize in Physiology or Medicine. Garrison-Morton 256.3 (Crick and Watson's paper); Grolier, One Hundred Books Famous in Medicine, 99; Heirs of Hippocrates 2342. Erling Norrby, Nobel Prizes: Cancer, Vision and the Genetic Code, 2019. Octavo, pp. 14. With 4 illustrations. Printed pamphlet, wire-stitched as issued. A few neat red pencil marks to first three pages, lower outer corners creased: a near-fine copy.

Two bound volumes. Volume 171 (January 3 1953 to June 27 1953) and Volume 172 (July 4 1953 to December 22 1953). Bound in maroon (vol. 171) and brick-red (vol. 172) cloth, spine lettered in gilt. In very good condition. Front pastedown has the bookplate of Worthing Public Library and title page of volume 172 (and verso of volume 171) has a small round Worthing Public Library stamp. The papers are as follows: 1. Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid, by J.D.Watson and F.H.C. Crick. Nature, Volume 171, No. 4356. April 25 1953. pp737-738. 2. Molecular Structure of Deoxypentose Nucleic Acids, by M.H.F. Wilkins, A.R.Stokes and H.R.Wilson Nature, Volume 171, No. 4356. April 25 1953. pp738-740. 3. Molecular configuration in Sodium Thymonucleate by Rosalind E. Franklin and R.G.Gosling. Nature, Volume 171, No. 4356. April 25 1953. pp740-741. 4. Genetical Implications of the Structure of Deoxyribonucleic Acid by J.D.Watson and F.H.C.Crick. Nature, Volume 171, No. 4361. May 30 1953. pp964-967. 5. Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate by Rosalind E. Franklin and R.G.Gosling. Nature, Volume 172, No. 4369, July 25 1953. pp156-157. 6. Helical Structure of Crystalline Deoxypentose Nucleic Acid, by M.H.F.Wilkins, W.E.Seeds, A.R.Stokes and H.R.Wilson. Nature, Volume 172, No. 4382, October 24 1953. pp759-762. Together these papers, announcing the discovery of DNA, provide the single most important advance in biology since Darwin's theories. Although Crick and Watson are the best known of the scientists working on the structure of deoxyribose nucleic acid (DNA) it was a collaborative venture and it is now recognised that the model used by Watson and Crick was based almost completely on the findings of Rosalind Franklin and Maurice Wilkins.

First edition. ONE OF THE MOST IMPORTANT SCIENTIFIC DISCOVERIES OF THE 20TH CENTURY. First edition, in the form in which it first appeared, of one of the most important scientific papers of the twentieth century, which ?records the discovery of the molecular structure of deoxyribonucleic acid (DNA), the main component of chromosomes and the material that transfers genetic characteristics in all life forms. Publication of this paper initiated the science of molecular biology. Forty years after Watson and Crick's discovery, so much of the basic understanding of medicine and disease has advanced to the molecular level that their paper may be considered the most significant single contribution to biology and medicine in the twentieth century? (One Hundred Books Famous in Medicine, p. 362). The paper ended with one of the most famous understatements in the history of science: ?It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.? The double helix describing the molecular structure of DNA has not only reshaped biology, it has become a cultural icon, represented in sculpture, visual art, jewellery, and toys. In 1962, Watson, Crick, and Wilkins shared the Nobel Prize in Physiology or Medicine ?for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material? (Franklin had died in 1958 and so was not eligible for the prize). This journal issue is actually much rarer at auction than the offprint. DNA was first isolated by the Swiss physician Friedrich Miescher in 1869, and over the succeeding years many researchers investigated its structure and function, with some arguing that it may be involved in genetic inheritance. In 1944 Oswald Avery, Maclyn McCarty, and Colin MacLeod published a paper showing how genes are composed of DNA, and Erwin Chargaff would observe that DNA contained equal amounts of adenine to thymine and of cytosine to guanine. But no one knew what it looked like or how it was copied. By the early 1950s this had become one of the most important questions in biology. After moving to King's College, London in 1947, Maurice Wilkins began research on the structure of DNA. In January 1951, Rosalind Franklin also moved to King's. Both worked on the structure of nucleic acids, but they clashed and one could not abide the other. Also working in King's were Alec Stokes and Bruce Fraser. By July 1951, Stokes had convincing mathematical evidence that DNA had a helical structure. In November 1951, Fraser built a model that turned out to have all the key elements correct?a helical shape, phosphates on the outside, and stacked bases separated by a distance of 3.4 angstroms?except for the number of chains. This research was completed before Watson began working with Crick. But neither Stokes nor Fraser published their findings. Having no one to talk to about his work, Wilkins discussed his frustrations?and research findings?with an old friend, Francis Crick, working at Cambridge University. Crick had a junior collaborator, James Watson, and the two had a warm and buoyant relationship in contrast to the antipathy between Franklin and Wilkins. Crick and Watson began their own investigation at the Cavendish Laboratory in Cambridge, in 1952, focusing on building molecular models. After one failed attempt in which they postulated a triple-helix structure, they were banned by the Cavendish from spending any additional time on the subject. On January 30, 1953, Watson visited King?s. Without Franklin?s permission, Wilkins showed her data to Watson?in particular, an X-ray crystallograph (of May 1952), the famous ?Photo 51? (which is reproduced in the third paper), that provided unquestionable evidence of the helical structure of DNA. The photograph struck Watson with the force of revelation. He sketched the pattern on the margin of his newspaper, and brought it back to Crick. Within four weeks, Watson and Crick had completed their model for the structure of DNA. In their published paper, they summarized their results as follows: ?We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest ? This structure has two helical chains each coiled round the same axis ? The novel feature of the structure is the manner in which the two chains are held together by the purine and pyrimidine bases ? only specific pairs of bases can bond together. These pairs are: adenine (purine) with thymine (pyrimidine), and guanine (purine) with cytosine (pyrimidine).? In their paper, Watson and Crick, referred to the Fraser model but dismissed it as ?rather ill-defined, and for this reason we shall not comment on it.? In developing their model, Watson and Crick never once touched or looked directly at a fibre of DNA. The article has no experiments, and consists of speculation based primarily on the experimental findings of the King?s researchers. In a footnote to a 1954 paper, ?The complementary structure of deoxyribonucleic acid,? (Proceedings of the Royal Society, Series A, 223, pp. 80?96), Crick and Watson wrote, ?we wish to point out that without this data [King?s] the formulation of our structure would have been most unlikely, if not impossible? And in 1999 Watson admitted, ?the Franklin photograph was the key event? ?Although recognized today as one of the seminal scientific papers of the twentieth century, Watson and Crick?s original article in Nature was not frequently cited at first. Its true significance became apparent, and its circulation widened, only towards the end of the 1950s, when the structure of DNA they had proposed was shown to provide a mechanism for controlling protein synthesis, and when their conclusions were confirmed in the laboratory by Matthew Meselson, Arthur Kornberg, and others. ?Crick himself immediately understood the significance of his and.

A VERY FINE SET OF THE DNA PAPERS. First edition, in the form in which they first appeared, of six crucial papers documenting the discovery of the structure of DNA and the mechanism of the genetic code. The first is Watson & Crick?s paper ?Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid?, which ?records the discovery of the molecular structure of deoxyribonucleic acid (DNA), the main component of chromosomes and the material that transfers genetic characteristics in all life forms. Publication of this paper initiated the science of molecular biology. Forty years after Watson and Crick's discovery, so much of the basic understanding of medicine and disease has advanced to the molecular level that their paper may be considered the most significant single contribution to biology and medicine in the twentieth century? (One Hundred Books Famous in Medicine, p. 362). Watson & Crick?s paper is here accompanied by their paper published one month later, ?Genetical Implications of the Structure of Deoxyribonucleic Acid,? ?in which they elaborated on their proposed DNA replication mechanism? (ibid.), together with one of the papers which provided the experimental data confirming their proposed structure, a follow up to ?Molecular Structure of Deoxypentose Nucleic Acids? by Wilkins et al. Also included is the 1961 paper ?General Nature of the Genetic Code for Proteins,? documenting Crick?s team?s efforts to crack the genetic code, amassing evidence suggesting that ?the amino-acid sequence along the polypeptide chain of a protein is determined by the sequence of the bases along some particular part of the nucleic acid of the genetic material? (p. 1227), and that each acid was most likely coded by a group of three bases. In 1962, Watson, Crick, and Wilkins shared the Nobel Prize in Physiology or Medicine ?for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material.? The first three papers were issued together in offprint from, but the journal issue offered here preceded the offprint and is actually rarer on the market. DNA was first isolated by the Swiss physician Friedrich Miescher in 1869, and over the succeeding years many researchers investigated its structure and function, with some arguing that it may be involved in genetic inheritance. By the early 1950s this had become one of the most important questions in biology. Maurice Wilkins of King's College London and his colleague Rosalind Franklin were both working on DNA, with Franklin producing X-ray diffraction images of its structure. Wilkins also introduced his friend Francis Crick to the subject, and Crick and his partner James Watson began their own investigation at the Cavendish Laboratory in Cambridge, focusing on building molecular models. After one failed attempt in which they postulated a triple-helix structure, they were banned by the Cavendish from spending any additional time on the subject. But a year later, after seeing new X-ray diffraction images taken by Franklin (notably the famous ?Photo 51?, which is reproduced in the third offered paper), they resumed their work and soon announced that not only had they discovered the double-helix structure of DNA, but even more importantly, that ?the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.? When Watson and Crick?s paper was submitted for publication in Nature, Sir Lawrence Bragg, the director of the Cavendish Laboratory at Cambridge, and Sir John Randall of King?s College agreed that the paper should be published simultaneously with those of two other groups of researches who had also prepared important papers on DNA: Maurice Wilkins, A.R. Stokes, and H.R. Wilson, authors of ?Molecular Structure of Deoxypentose Nucleic Acids,? and Rosalind Franklin and Raymond Gosling, who submitted the paper ?Molecular Configuration in Sodium Thymonucleate.? The three papers were published in Nature under the general title ?The Molecular Structure of Nucleic Acids.? ?Five weeks after Watson's and Crick's first paper in Nature, their second appeared, in which, after explaining the structure and the evidence all over again, they pursued some of the genetical implications. These flowed from the most novel, most fundamental fact of the model: ?Any sequence of the pairs of the bases can fit into the structure. It follows that in a long molecule many different permutations are possible, and it therefore seems likely that the precise sequence of the bases is the code which carries the genetical information. If the actual order of the bases on one of the pair of chains were given, one could write down the exact order of the bases on the other one, because of the specific pairing.? This immediately suggested, they said, how DNA duplicated itself. ?Previous discussions of self-duplication have usually involved the concept of a template, or mould. Either the template was supposed to copy itself directly or it was to produce a ?negative?, which in its turn was to act as a template and produce the original "positive" once again. In no case has it been explained in detail how it would do this in terms of atoms and molecules.? The elucidation of the structure of DNA called for a new kind of functional explanation. ?Now our model for deoxyribonucleic acid is, in effect, a pair of templates, each of which is complementary to the other. We imagine that prior to duplication the hydrogen bonds [connecting the bases in pairs] are broken, and the two chains unwind and separate. Each chain then acts as a template for the formation on to itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before. Moreover, the sequence of the pairs of bases will have been duplicated exactly.? Yet perhaps not always exactly: the model, or rather the mistake whose correction by Donohue had cleared the way for the m.

Nature 1953. 8vo. 2 vols. Contemporary red morocco backed buckram, gilt lettering to spine; vols 171 and 172 of the journal Nature, covering 1953; diagrams and illustrations; very good.First editions of the first papers on the ground-breaking discovery of the structure of DNA, comprising: "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid", in Nature Vol.171, No. 4356, pp.737-738, 25th April, 1953 [and] Wilkins, Maurice H.F., A.R. Stokes and H.R. Wilson. "Molecular Structure of Deoxypentose Nucleic Acids", in Nature Vol.171, No. 4356, pp.738-740, 25th April, 1953 [and] Franklin (Rosalind E.) and R.G. Gosling. "Molecular Configuration in Sodium Thymonucleate", in Nature Vol.171, No. 4356, pp.740-741, 25th April, 1953 [and] Watson (James D.) & Francis Crick. "Genetic Implications of the Structure of Deoxyribonucleic Acid", in Nature Vol.171, No. 4361, pp.964-967, 30th May, 1953 [and] Wilkins (M. H. F.), W. E. Seeds, A. R. Stokes and H. R. Wilson. "Helical Structure of Crystalline Deoxypentose Nucleic Acid", in Nature, vol.172, No. 4382, pp.759-762, 24th October, 1953.These papers record the greatest biological advance of the twentieth century, a discovery which won Crick, Watson and Wilkins the Nobel Prize.

Original photograph from the 1962 Nobel Prize Ceremony signed by Francis Crick, James Watson, and Maurice Wilkins (jointly awarded the 1962 Nobel Prize in Physiology and Medicine) as well as Max Ferdinand Perutz and John Kendrew (jointly awarded the 1962 Nobel Prize in Chemistry). Also captured in the photograph is John Steinbeck, who was awarded the 1962 Nobel Prize in Literature. In fine condition. The Nobel Prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and Maurice Hugh Frederick Wilkins "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material." In 1968, Watson published The Double Helix: A Personal Account of the Discovery of the Structure of DNA, his account of his codiscovery (along with Francis Crick) of the structure of DNA. To preserve the "real" story for the world, James Watson attempted to record his first impressions as soon after the events of 1951-1953 as possible, with all their unpleasant realities and "spirit of adventure" intact. "He has described admirably how it feels to have that frightening and beautiful experience of making a great scientific discovery" (Richard Feynman, winner of the 1965 Nobel Prize for Physics).

This long, heavily illustrated article, takes up more than a third of this issue of the periodical. Of particular interest is Part III, subtitled "Seven Giants Who Led the Way." It profiles Anton van Leeuwenhoek, Charles Darwin, Gregor Mendel, Louis Pasteur, Thomas Hunt Morgan, and James Watson and Francis Crick. Watson and Crick have both signed the section of the article that is about them. Original printed wrappers, chipped at spine. Rubberstamp of Francis H.C. Crick at the Salk Institute on front cover. This issue was given by Crick to an employee at the Salk.