Gullick William John (27 results)
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Published by Springer, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Condition: Fair. Verschmutzung / Wasserschaden; Abnutzung / Risse - leicht. The epidermal growth factor (EGF) receptor and its downstream signaling networks are crucial in tumor development and maintenance, driving the search for targeted anti-EGF receptor therapies. Extensive research has detailed the EGF receptor's structure,…ligand binding domains, intrinsic tyrosine kinase function, and interactions with signaling adaptor proteins like SH2, PTB, and SH3, which are essential for signal transduction. The EGF receptor serves as a central hub for various signaling pathways and interacts with three other family receptors, forming dimers and oligomers in response to at least eleven ligands, some of which have overlapping or distinct functions. This interaction activates multiple second messenger proteins and facilitates cross-talk between systems, adding complexity to the signaling landscape. However, the cross-regulation of the EGF receptor with other anti-apoptotic, mitogenic, and metabolic signaling systems remains less understood. New findings continue to emerge from studying these interactions, although a significant challenge has been the tendency to define signaling pathways without considering their tissue-specific or cell-interaction contexts.
Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Language: English
Published by Humana Press, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Condition: New. pp. xi + 393 1st Edition.
Language: English
Published by Humana Press, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Condition: New. pp. xi + 393 Illus.
Language: English
Published by Humana Press, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios
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Condition: New. pp. xi + 393.
Language: English
Published by SP SPRINGER, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
- International Edition
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Condition: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if th…e Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.
Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.
Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Language: English
Published by Humana Pr Inc, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
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Brossura. Condition: fine. 2008; br., pp. 393, cm 26x18. Libro.
Language: English
Published by Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
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Taschenbuch. Condition: Neu. EGFR Signaling Networks in Cancer Therapy | William John Gullick (u. a.) | Taschenbuch | xi | Englisch | 2011 | Humana Press | EAN 9781617378539 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer…[dot]com | Anbieter: preigu.
Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
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Hardcover. Condition: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.
Language: English
Published by Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
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Paperback. Condition: Brand New. 404 pages. 10.24x7.60x0.96 inches. In Stock.
Language: English
Published by Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
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Condition: New. pp. xi + 393.
Language: English
Published by Humana, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
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Condition: new. Questo è un articolo print on demand.
Language: English
Published by Humana Press, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
- Print on Demand
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Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancersDescribes EGF receptor in a tumor tissue specific context Illustrates the many ways i…n which EGF receptors contribute .
Language: English
Published by Humana Press Sep 2008, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
- Print on Demand
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted a…nti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context. 408 pp. Englisch.
Language: English
Published by Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
Seller: moluna, Greven, Germanymoluna
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Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancersDescribes EGF receptor in a tumor tissue specific context Illustrates…the many ways in which EGF receptors contribute .
Language: English
Published by Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
- Print on Demand
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Buch. Condition: Neu. EGFR Signaling Networks in Cancer Therapy | William John Gullick (u. a.) | Buch | xi | Englisch | 2008 | Humana | EAN 9781588299482 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter:… preigu Print on Demand.
Language: English
Published by Humana Press Jan 2011, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly tar…geted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context. 408 pp. Englisch.
Language: English
Published by Humana Press, Humana Sep 2008, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-…EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 408 pp. Englisch.
Language: English
Published by Humana Press, Humana, 2008
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Hardcover
- Print on Demand
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-E…GF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.
Language: English
Published by Humana Press, Humana Press Jan 2011, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targete…d anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 408 pp. Englisch.
Language: English
Published by Humana Press, Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted… anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.
Language: English
Published by Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
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Condition: New. Print on Demand pp. xi + 393.
Language: English
Published by Humana Press, 2011
Series: Cancer Drug Discovery and Development, Book 56 of 96. Book 56 of 96 - Cancer Drug Discovery and Development
- Softcover
- Print on Demand
Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios
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Condition: New. PRINT ON DEMAND pp. xi + 393.
