9780123049902 - Neuropeptide Y and Drug Development (2 results)

Hardcover. Condition: Très bon. Ancien livre de bibliothèque avec équipements. Edition 1996. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1996. Ammareal gives back up to 15% of this item's net price to charity organizations.

Hardcover. Condition: Very Good. Hardcover, xii + 209 pages, NOT ex-library. Clean, bright, tight. Unmarked text, free of inscriptions and stamps. Published without a dust jacket. -- Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. Key Features: - The hypothalamic role of NPY and its relationship with eating disorders and diabetes; - The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders; - Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology; - Development of peptide and non-peptide receptor antagonists. -- Contents: 1. Multiple Receptors and Multiple Actions; 2. Central Effects of Neuropeptide Y With Emphasis on Its Role in Obesity and Diabetes; 3. Neuropeptide Y in Sympathetic Nerves: Evidence for Yl Receptor Mediated Vascular Control; 4. Neuropeptide Y Receptor Types in Mammalian Brain: Species Differences and Status in the Human Central Nervous System; 5. Extraordinary Structural Diversity of Npy-family Receptors; 6. The Importance of Various Parts of the Npy Molecule for Receptor Recognition; 7. Peptide Antagonists of Neuropeptide Y: Design, Structure and Pharmacological Characterization; 8. Sr 120819a or the First Generation of Orally Active Yl Receptor Antagonists; 9. Bibp 3226, a Potent and Selective Neuropeptide Y Yl Receptor Antagonist. Structure-activity Studies and Localization of the Human Yl Receptor Binding Site.