9781441921345 - Statistical Monitoring of Clinical Trials: a Unified Approach (statistics for Biology and Health) by Proschan, Michael A. A.; Lan, K. K. Gordon; Wittes, Janet Turk (9 results)
Statistical Monitoring of Clinical Trials: A Unified Approach (Statistics for Biology and Health)
Proschan, Michael A. A.; Lan, K. K. Gordon; Wittes, Janet Turk
Language: English
Published by Springer 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
Seller: Ria Christie Collections, Uxbridge, United KingdomRia Christie Collections
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Language: English
Published by Springer, Springer 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial ou…tcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ('the B-value') irrespective of the test statistic. The so-called B-value approach to monitoring allows us to use, for different types of trials, the same boundaries and the same simple formula for computing conditional power. Although Brownian motion may sound complicated, the authors make the approach easy by starting with a simple example and building on it, one piece at a time, ultimately showing that Brownian motion works for many different types of clinical trials.The book will be very valuable to statisticians involved in clinical trials. The main body of the chapters is accessible to anyone with knowledge of a standard mathematical statistics text. More mathematically advanced readers will find rigorous developments in appendices at the end of chapters. Reading the book will develop insight into not only monitoring, but power, survival analysis, safety, and other statistical issues germane to clinical trials.Michael Proschan, Gordon Lan, and Janet Wittes are elected Fellows of the American Statistical Association. All have spent formative years in the Biostatistics Research Branch of the National Heart, Lung, and Blood Institute (NHLBI/NIH). While there, they were intimately involved in the design and statistical monitoring of large-scale randomized clinical trials, developing methodology to aid in their monitoring. For example, Lan developed, with DeMets, the now widely-used spending function approach to group sequential designs, whose properties were further investigated byProschan. The B-value approach used in the book was introduced in a very influential paper by Lan and Wittes. The statistical theory behind conditional power was developed by Lan, along with Simon and Halperin, and was the cornerstone for the conditional error approach to adaptive clinical trials introduced by Proschan and Hunsberger. All three authors have expertise in adaptive methodology for clinical trials.Michael Proschan is a Mathematical Statistician at the National Institutes of Health; Gordon Lan is Senior Director of Biometrics at Johnson & Johnson Pharmaceutical Research and Development, L.L.C.; Janet Wittes is President of Statistics Collaborative, a statistical consulting company she founded in 1990.
Language: English
Published by Springer New York 2006
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
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Paperback. Condition: Brand New. 278 pages. 9.00x6.00x0.62 inches. In Stock.
Language: English
Published by Springer 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
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Language: English
Published by Springer 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
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Condition: new. Questo è un articolo print on demand.
Language: English
Published by Springer New York Nov 2010 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
- Print on Demand
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of c…linical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ('the B-value') irrespective of the test statistic. The so-called B-value approach to monitoring allows us to use, for different types of trials, the same boundaries and the same simple formula for computing conditional power. Although Brownian motion may sound complicated, the authors make the approach easy by starting with a simple example and building on it, one piece at a time, ultimately showing that Brownian motion works for many different types of clinical trials.The book will be very valuable to statisticians involved in clinical trials. The main body of the chapters is accessible to anyone with knowledge of a standard mathematical statistics text. More mathematically advanced readers will find rigorous developments in appendices at the end of chapters. Reading the book will develop insight into not only monitoring, but power, survival analysis, safety, and other statistical issues germane to clinical trials.Michael Proschan, Gordon Lan, and Janet Wittes are elected Fellows of the American Statistical Association. All have spent formative years in the Biostatistics Research Branch of the National Heart, Lung, and Blood Institute (NHLBI/NIH). While there, they were intimately involved in the design and statistical monitoring of large-scale randomized clinical trials, developing methodology to aid in their monitoring. For example, Lan developed, with DeMets, the now widely-used spending function approach to group sequential designs, whose properties were further investigated byProschan. The B-value approach used in the book was introduced in a very influential paper by Lan and Wittes. The statistical theory behind conditional power was developed by Lan, along with Simon and Halperin, and was the cornerstone for the conditional error approach to adaptive clinical trials introduced by Proschan and Hunsberger. All three authors have expertise in adaptive methodology for clinical trials.Michael Proschan is a Mathematical Statistician at the National Institutes of Health; Gordon Lan is Senior Director of Biometrics at Johnson & Johnson Pharmaceutical Research and Development, L.L.C.; Janet Wittes is President of Statistics Collaborative, a statistical consulting company she founded in 1990. 272 pp. Englisch.
Language: English
Published by Springer New York 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
- Print on Demand
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Offers an accessible, incremental approach to understanding Brownian motion as related to clinical trialsShows how to use the B-value approach to monitoring different types of trialsAll three authors are experts in ad…aptive methodology for .
Language: English
Published by Springer-Verlag New York Inc. 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
- Print on Demand
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Paperback / softback. Condition: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days.
Language: English
Published by Springer, Springer Nov 2010 2010
Series: Statistics for Biology and Health, Book 19 of 69. Book 19 of 69 - Statistics for Biology and Health
- Softcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clin…ical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ('the B-value') - irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials. The main body of the chapters is accessible to anyone with knowledge of a standard mathematical statistics text. More mathematically advanced readers will find rigorous developments in appendices at the end of chapters. Reading the book will develop insight into not only monitoring, but power, survival analysis, safety, and other statistical issues germane to clinical trials.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 272 pp. Englisch.
