springer new york mai 2018 (110 results)

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This textbook aims to fill the gap between those that offer atheoretical treatment without many applications and those that presentand apply formulas without appropriately deriving them. The balanceachieved will give readers a fundamental understanding of key financialideas and tools that form the basis for building realistic models,including those that may become proprietary. Numerous carefully chosenexamples and exercises reinforce the student's conceptual understandingand facility with applications. The exercises are divided intoconceptual, application-based, and theoretical problems, which probe thematerial deeper.The book is aimed toward advanced undergraduates and first-year graduatestudents who are new to finance or want a more rigorous treatment of themathematical models used within. While no background in finance isassumed, prerequisite math courses include multivariable calculus,probability, and linear algebra. The authors introduce additionalmathematical tools as needed. The entire textbook is appropriate for asingle year-long course on introductory mathematical finance. Theself-contained design of the text allows for instructor flexibility intopics courses and those focusing on financial derivatives. Moreover,the text is useful for mathematicians, physicists, and engineers whowant to learn finance via an approach that builds their financialintuition and is explicit about model building, as well as businessschool students who want a treatment of finance that is deeper but not overly theoretical. 504 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides a full explanation and technical details to perform surgical techniques properly on small and large animal models. The first six chapters of Experimental Neurosurgery in Animal Models focus primarily on the brain, while the next six chapters concern the spinal cord in rodents. The last four chapters provide a description of operative procedures in large animals. Written for the popular Neuromethodsseries, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical,Experimental Neurosurgery in Animal Models aimsto ensure successful results in the further study of this vital field. 268 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is open access under a CC BY-NC 2.5 license.The Gulf of Mexico is an open and dynamic marine ecosystem rich in natural resources but heavily impacted by human activities, including agricultural, industrial, commercial and coastal development. The Gulf of Mexico has been continuously exposed to petroleum hydrocarbons for millions of years from natural oil and gas seeps on the sea floor, and more recently from oil drilling and production activities located in the water near and far from shore. Major accidental oil spills in the Gulf are infrequent; two of the most significant include the Ixtoc I blowout in the Bay of Campeche in 1979 and the Deepwater Horizon Oil Spill in 2010. Unfortunately, baseline assessments of the status of habitats and biota in the Gulf of Mexico before these spills either were not available, or the data had not been systematically compiled in a way that would help scientists assess the potential short-term and long-term effects of such events.This 2-volume series compiles and summarizes thousands of data sets showing the status of habitats and biota in the Gulf of Mexico before the Deepwater Horizon Oil Spill. Volume 2 covers historical data on commercial and recreational fisheries, with an analysis of marketing trends and drivers; ecology, populations and risks to birds, sea turtles and marine mammals in the Gulf; and diseases and mortalities of fish and other animals that inhabit the Gulf of Mexico. 956 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume providesa sound basis for the molecular investigation of NLR function in health anddisease. Chapters focus on of innate immune receptors, 'atypical'inflammasomes, biochemical and novel bioluminescencetechniques for the measurement of IL-1b,bioluminescent probe, biochemical and microscopytechniques, techniques to measure caspase-1 activation, cellfree systems for the study of inflammasome function, and inflammasomeactivation. Written in the highly successful Methodsin Molecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Authoritativeand cutting-edge, NLR Proteins: Methodsand Protocols aims to ensure successful results in the further study ofthis vital field. 272 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is directed at individuals interested in the field of neuroscience who are novices or experts in the use of transmission electron microscopy. The goal of is to provide a comprehensive series of chapters on how this tool can be used to study the brain with a strong emphasis on successful hands-on application of the electron microscopy technique. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Concise and easy-to-use,Transmission Electron Microscopy Methods for Understanding the Brainaims to ensure successful results in the further study of this vital field. 260 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethodsseries, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical,Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aimsto ensure successful results in the further study of this vital field. 308 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume provides different methodologies for all classes of histone deacetylases, which includes detailed procedures on Class I and II histone deacetylase inhibitors, SIRT inhibitors, and bromodomain inhibitors. Histone Deacetylases: Methods and Protocols is divided into four sections: Sections A and B describe methodologies used to detect the activity, function, or chromatin location of HDACs 1 through 11, with Section A discussing Class I and Section B discussing class II histone deacetylases; Section C focuses on the methodologies for cloning and characterizing the acetylation of SIRTs 1 through 7; and Section D describes methods related to histone deacetylase inhibitors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, Histone Deacetylases: Methods and Protocols, is a valuable resource for investigators working on epigenetics, molecular biology, and genetics. 352 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume focuses on the optogenetics workflow, and covers topics on viral vectors, targeting strategies, choice on opsins, animal models and readouts, and applications in systems neuroscience. This book shows readers how to identify the critical aspects of each methodological step, and how to determine the necessary level of complexity to address the particular research question. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Comprehensive and cutting-edge, Optogenetics: A Roadmap is a valuable guide for both the optogenetics novices and the experts. 316 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advanced maths students have been waiting for this, the third edition of a text that deals with one of the fundamentals of their field. This book contains a systematic treatment of probability from the ground up, starting with intuitive ideas and gradually developing more sophisticated subjects, such as random walks and the Kalman-Bucy filter. Examples are discussed in detail, and there are a large number of exercises. This third edition contains new problems and exercises, new proofs, expanded material on financial mathematics, financial engineering, and mathematical statistics, and a final chapter on the history of probability theory. 504 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is the first book to cover GRASP (Greedy Randomized Adaptive Search Procedures), a metaheuristic that has enjoyed wide success in practice with a broad range of applications to real-world combinatorial optimization problems. The state-of-the-art coverage and carefully crafted pedagogical style lends this book highly accessible as an introductory text not only to GRASP, but also to combinatorial optimization, greedy algorithms, local search, and path-relinking, as well as to heuristics and metaheuristics, in general. The focus is on algorithmic and computational aspects of applied optimization with GRASP with emphasis given to the end-user, providing sufficient information on the broad spectrum of advances in applied optimization with GRASP. For the more advanced reader, chapters on hybridization with path-relinking and parallel and continuous GRASP present these topics in a clear and concise fashion. Additionally, the book offers a very complete annotated bibliography of GRASP and combinatorial optimization. For the practitioner who needs to solve combinatorial optimization problems, the book provides a chapter with four case studies and implementable templates for all algorithms covered in the text.This book, with its excellent overview of GRASP, will appeal to researchers and practitioners of combinatorial optimization who have a need to find optimal or near optimal solutions to hard combinatorial optimization problems. 332 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Model-Based Systems Engineering (MBSE), which tackles architecting and design of complex systems through the use of formal models, is emerging as the most critical component of systems engineering.This textbook specifies the two leading conceptual modeling languages, OPM-the new ISO 19450, composed primarily by the author of this book, and OMG SysML. It provides essential insights into a domain-independent, discipline-crossing methodology of developing or researching complex systems of any conceivable kind and size. Combining theory with a host of industrial, biological, and daily life examples, the book explains principles and provides guidelines for architecting complex, multidisciplinary systems, making it an indispensable resource for systems architects and designers, engineers of any discipline, executives at all levels, project managers, IT professional, systems scientists, and engineering students. 436 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Lively prose and imaginative exercises draw the reader into this unique introductory real analysis textbook. Motivating the fundamental ideas and theorems that underpin real analysis with historical remarks and well-chosen quotes, the author shares his enthusiasm for the subject throughout. A student reading this book is invited not only to acquire proficiency in the fundamentals of analysis, but to develop an appreciation for abstraction and the language of its expression.In studying this book, students will encounter:the interconnections between set theory and mathematical statements and proofs;the fundamental axioms of the natural, integer, and real numbers;rigorous -N and -d definitions;convergence and properties of an infinite series, product, or continued fraction;series, product, and continued fraction formulæ for the various elementary functions and constants.Instructors will appreciate this engaging perspective, showcasing the beauty of these fundamental results. 740 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The revised second edition of this established text offers readers a significantly expanded introduction to the effects of radiation on metals and alloys. It describes the various processes that occur when energetic particles strike a solid, inducing changes to the physical and mechanical properties of the material. Specifically it covers particle interaction with the metals and alloys used in nuclear reactor cores and hence subject to intense radiation fields. It describes the basics of particle-atom interaction for a range of particle types, the amount and spatial extent of the resulting radiation damage, the physical effects of irradiation and the changes in mechanical behavior of irradiated metals and alloys.Updated throughout, some major enhancements for the new edition include improved treatment of low- and intermediate-energy elastic collisions and stopping power, expanded sections on molecular dynamics and kinetic Monte Carlo methodologies describing collision cascade evolution, new treatment of the multi-frequency model of diffusion, numerous examples of RIS in austenitic and ferritic-martensitic alloys, expanded treatment of in-cascade defect clustering, cluster evolution, and cluster mobility, new discussion of void behavior near grain boundaries, a new section on ion beam assisteddeposition, and reorganization of hardening, creep and fracture of irradiated materials (Chaps 12-14) to provide a smoother and more integrated transition between the topics.The book also contains two new chapters. Chapter 15 focuses on the fundamentals of corrosion and stress corrosion cracking, covering forms of corrosion, corrosion thermodynamics, corrosion kinetics, polarization theory, passivity, crevice corrosion, and stress corrosion cracking. Chapter 16 extends this treatment and considers the effects of irradiation on corrosion and environmentally assisted corrosion, including the effects of irradiation on water chemistry and the mechanisms of irradiation-induced stress corrosion cracking.The book maintains the previous style, concepts are developed systematically and quantitatively, supported by worked examples, references for further reading and end-of-chapter problem sets. Aimed primarily at students of materials sciences and nuclear engineering, the book will also provide a valuable resource for academic and industrialresearch professionals.Reviews of the first edition:'.nomenclature, problems and separate bibliography at the end of each chapter allow to the reader to reach a straightforward understandingof the subject, part by part. . this book is very pleasant to read, well documented and can be seen as a very good introduction to the effects of irradiation on matter, or as a good references compilation for experimented readers.' - Pauly Nicolas, Physicalia Magazine, Vol. 30 (1), 2008'The text provides enough fundamental material to explain the science and theory behind radiation effects in solids, but is also written at a high enough level to be useful for professional scientists. Its organization suits a graduate level materials or nuclear science course. the text was written by a noted expert and active researcher in the field of radiation effects in metals, the selection and organizationof the material is excellent. may well become a necessary reference for graduate students and researchers in radiation materials science.'- L.M. Dougherty, 07/11/2008, JOM, the Member Journal of The Minerals, Metals and Materials Society. 1032 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book grew out of the need to provide students with a solid introduction to modern fluid dynamics. It offers a broad grounding in the underlying principles and techniques used, withsomeemphasis on applications in astrophysicsand planetary science. The bookcomprehensively coversrecentdevelopments, methods and techniques, including, for example, new ideas on transitions to turbulence (via transiently growing stable linear modes), new approaches to turbulence (which remains the enigma of fluid dynamics), and the use of asymptotic approximation methods, which can give analytical or semi-analytical results and complement fully numerical treatments. The authors also briefly discuss some important considerations to be taken into account when developing a numerical code for computer simulation offluidflows. Although the text is populated throughout with examples and problems from the field of astrophysicsand planetary science, the text is eminently suitable as a general introduction to fluid dynamics. It is assumed that the readers are mathematically equipped with a reasonable knowledge in analysis, including basics of ordinary and partial differential equations and a good command of vector calculus and linear algebra. Each chapter concludes with bibliographical notesin which the authors briefly discuss thechapter'sessential literature and give recommendations for further, deeper reading. Included in each chapter are a number ofproblems, some of themrelevant to astrophysicsand planetary science.The book is written for advanced undergraduate and graduate students, but will also prove a valuable source of reference for established researchers. 704 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This second edition textbook offers an expanded conceptual synthesis of microbial ecology with plant and animal ecology. Drawing on examples from the biology of microorganisms and macroorganisms, this textbook provides a much-needed interdisciplinary approach to ecology. The focus is the individual organism and comparisons are made along six axes: genetic variation, nutritional mode, size, growth, life cycle, and influence of the environment. When it was published in 1991, the first edition of Comparative Ecology of Microorganisms and Macroorganisms was unique in its attempt to clearly compare fundamental ecology across the gamut of size. The explosion of molecular biology and the application of its techniques to microbiology and organismal biology have particularly demonstrated the need for interdisciplinary understanding. This updated and expanded edition remains unique. It treats the same topics at greater depth and includes an exhaustive compilation of both the most recent relevant literature in microbial ecology and plant/animal ecology, as well as the early research papers that shaped the concepts and theories discussed. Among the completely updated topics in the book are phylogenetic systematics, search algorithms and optimal foraging theory, comparative metabolism, the origins of life and evolution of multicellularity, and the evolution of life cycles.From Reviews of the First Edition: 'John Andrews has succeeded admirably in building a bridge that is accessible to all ecologists.'-Ecology'I recommend this book to all ecologists. It is a thoughtful attempt to integrate ideas from, and develop common themes for, two fields of ecology that should not have become fragmented.'-American Scientist'Such a synthesis is long past due, and it is shameful that ecologists (both big and little) have been so parochial.'-The Quarterly Review of Biology 368 pp. Englisch.

Taschenbuch. Condition: Neu. Neuware.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents state-of-the-art protocols for key experiments that have revolutionized our understanding of the bacterial nucleoid. This book is divided into five parts: Part I introduces molecular genetic methods to study bacterial nucleoids; Part II highlights the study of bacterial nucleoid with whole genome analysis method; Part III discusses molecular biology methods to study nucleoid structuring factors; Part IV looks at imaging bacterial nucleoid; and Part V explores biophysics of the bacterial nucleoid. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, The Bacterial Nucleoid: Methods and Protocols is a valuable resource that provides a wealth of new information about this chromosome. 392 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume discusses methods for the study of multipotent and pluripotentstem cells of the hair follicle. The stem cells described are involved in boththe growth of the hair follicle and its production of the hair shaft, as wellas the growth of the hair follicle sensory nerve. Multipotent Stem Cells ofthe Hair Follicle: Methods and Protocols also explores very unexpectedresults such as that of the hair follicle-associated-pluripotent (HAP) stemcells, which not only have the capability for regenerating the hair folliclesensory nerve, but also can differentiate ex vivo and in vivo to multiple celltypes not associated with the hair follicle-these include glial cells, motorneurons, and beating cardiac muscle cells. The potential for HAP stem cells forregenerative medicine is also discussed in detail. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Cutting-edgeand thorough, Multipotent Stem Cells of the Hair Follicle: Methods andProtocolsis a valuable resource for researchers interested in thisfield. 192 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Presentingstate-of-the-art protocols to study gap junctions, this detailed book firstfocuses on the use of methods and tools to investigate the different aspects ofconnexin expression and gap junction regulation. The second part of the volumedescribes several methods to probe gap junction functionality as such. Writtenin the highly successful Methods in Molecular Biology series format, chaptersinclude introductions to their respective topics, lists of the necessarymaterials and reagents, step-by-step and readily reproducible laboratoryprotocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritativeand practical, Gap Junction Protocols is intended for basic and appliedresearchers in the area of biomedical and life sciences, both in academic andindustrial settings. 252 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This third edition volumeexpands on the previous editions both by presenting more detailed protocols forthe techniques described in the first and second editions of High ThroughputScreening: Methods and Protocolsand by covering important new procedures. The first chapter ofthis book provides an overview of important assay development techniques, whilethe rest of the chapters detail how to develop and execute screens at whateverthroughput the user needs. Some chapter examples are: structure-based virtualscreening, high throughput screening using mass spectrometry, identification of state-dependentblockers for voltage gated calcium channels, bioluminescence resonanceenergy transfer platform to monitor protein-protein interactions in live cells,high throughput flow cytometry, and application of imaging-based assays in microplate formats for highcontent screening. Written in the highly successful Methods in MolecularBiology series format, chapters include introductions to their respectivetopics, lists of the necessary materials and reagents, step-by-step, readilyreproducible laboratory protocols, and tips on troubleshooting and avoidingknown pitfalls.Cutting edge and thorough, High Throughput Screening: Methods and Protocols,Third Edition, is a valuable resource for anyone who is interested in HTSresearch. 320 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume explores data from the applications of molecular biological methods and the applications of recent immunological and cytogenetic methods in Epstein-Barr Virus (EBV) that will offer readers possible new solutions to the unresolved problems in the EBV field. Chapters in this book cover topics such as: viral life cycle, latency, EBV-associated diseases and EBV diagnostics; in vitro methods including organotypic cultures for the analysis of EBV-epithelial cell interactions; identification of the interacting viral and cellular proteins using affinity purification-mass spectrometry methods; 3D telomere FISH; transcription analysis using high-throughput RNA sequencing, qPCR and nuclear run-on assay; analysis of viral and cellular microRNAs; isolation and characterization of exosomes and the assessment of their function; characterization of the viral genome by terminal repeat analysis and sequencing; the use of chromatin immunoprecipitation coupled sequencing (ChIP-Seq) for the analysis of Zta-DNA interactions; epigenetic analysis by bisulfite sequencing and ChIP; novel in vivo models for the study of EBV infection; and how immunological, virological, tissue culture and molecular methods can be combined to yield Good Manufacturing Practice-compliant EBV-specific T cells for the immunotherapy of EBV-associated post-transplant lymphoproliferative diseases (PTLD). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Epstein Barr-Virus: Methods and Protocols is a valuable resource for anyone who is interested in this fascinating and evolving field. 284 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The third edition of thisvolume is aimed at providing both beginners and more experienced researchers achoice of methods to isolate and analyze dendritic cells(DC). An introductoryreview provides an overview of recent advances in the characterization of DCsubsets in mouse and human. While additional chapters provide methods toculture human and mouse dendritic cells, protocols for the isolation ofdendritic cells, the isolation of dendritic cell progenitors from mouse, andthe purification of dendritic cells from human blood. Written in the highlysuccessful Methods in Molecular Biology series format, chapters includeintroductions to their respective topics, lists of the necessary materials andreagents, step-by-step, readily reproducible laboratory protocols, and tips ontroubleshooting and avoiding known pitfalls.Authoritative andcutting-edge, Dendritic CellProtocols, Third Edition aims to ensure successful results in the furtherstudy of this vital field. 336 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents the latest protocols for both laboratory andbioinformatics based analyses in the field of marine genomics. The chapterspresented in the book cover a wide range of topics, including the sampling andgenomics of bacterial communities, DNA extraction in marine organisms,high-throughput sequencing of whole mitochondrial genomes, phylogenomics, SNPdiscovery, SNP-arrays for species identification, digital PCR-basedquantification methods, environment DNA for invasive species surveillance andmonitoring, microarrays for the detection of waterborne pathogens, DNAbarcoding of marine biodiversity, metabarcoding protocols for marineeukaryotes, analytical protocols for the visualization of eukaryotic diversity,and applications for genomic data to benthic indices for environmentalmonitoring. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introduction to their respective topics, listsof the necessary materials and reagents, step-by-step, readily reproduciblelaboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Marine Genomics: Methods and Protocols is avaluable resource for researchers, students, and policy makers in the field ofmarine biology. 264 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory.Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies. 344 pp. Englisch.

Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory. Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research. 240 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a comprehensive, state-of-the art review of the intersection of male and female reproductive and sexual health. The text comprehensively discusses the evaluation and management of physical, genetic, and psychological causes of male and female sexual dysfunction. Discussion of treatment focuses on current medical and surgical psychosexual therapies in both the male and female. The book highlights erectile, ejaculatory, and orgasmic disorders in the male; desire, arousal and orgasmic disorders in the female; and an integrated approach to the couple. Lifestyle modifications through diet and exercise and optimization of anthropomorphic characteristics are also discussed, including a holistic approach to these disorders that goes beyond a focus on the genital system alone. Sexual Dysfunction in Men and Women: An Interdisciplinary Approach serves as a resource for physicians and researchers interested in sexual medicine seeking a comprehensive overview of the practice and novel research in the field. 412 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thisvolume is a collection of detailed protocols describing state-of-art approachesthat will facilitate the understanding of protein homeostasis in plant stressresponses and development. Plant Proteostasis: Methods and Protocols is broken into four parts focusing on thestudy of ubiquitin-dependent post-translational modifications, protocolsfocused on Ubl post-translational modifications, protein homeostasis, andprotocols for the in silico analysis. Written in the highly successful Methods in Molecular Biology seriesformat, chapters include introductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Plant Proteostasis: Methods andProtocols aims to address next challenges in agriculture such asprecision horticulture. 320 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of this volume is to present current methodologies to predict and understand the pathogenesis of Type-1 Diabetes for clinical and non-clinical researchers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Practical and reliable, Type-1 Diabetes: Methods and Protocols will aid researchers in using these methods to advance their own studies. 224 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This meticulous volume recognizes the need to translate what has been learned primarily in tissue culture dishes to approaches supporting scale-up studies, not only to large quantities of cells but also to heterogeneous cell constructs. Notable advances are being made in these latter approaches, prompting this collection of a variety of representative protocols that facilitate important modifications and novel approaches to bioreactors in stem cell research, contributed by both established and new investigators in this area. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and authoritative, Bioreactors in Stem Cell Biology: Methods and Protocols will serve as an ideal guide for scientists seeking to increase our understanding of stem cells and their potential to repair and regenerate tissues and organs. 256 pp. Englisch.

Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is an important new resource for clinicians caring for ventilator dependent children, who often have complex health care needs, are supported by advanced technology and are at high-risk of serious complications. Despite the complicated health care needs of children who rely on chronic respiratory support, there are few guidelines and little evidence available to guide the clinicians who care for these patients. This book covers the many aspects involved in the care of these complex children, with input from experts in the fields of pediatric pulmonology, intensive care, ethics, respiratory therapy, and nursing. In depth chapters provide an introduction to the use of chronic invasive and non-invasive ventilation in children and describe and review what is known about methods of delivering ventilator support, care of the chronically ventilated patient in the community , use of chronic ventilator support in patients with disorders commonly leading to respiratory failure and outcomes for patients and their caregivers.This book is intended to be useful not only for pediatric pulmonologists, but also for intensivists, cardiologists, physical medicine/rehabilitation specialists, nurses, respiratory therapists and the primary care physicians involved in the complexities of managing care for this unique group of special needs children. 376 pp. Englisch.