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  • Jürgen Drews

    Language: English

    Published by Springer New York, Springer New York Jan 2003, 2003

    ISBN 10: 0387955429 ISBN 13: 9780387955421

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    Taschenbuch. Condition: Neu. Neuware -An eminent scientist talks about the pharmaceutical industry, biotechnology and the future of drug research. In the course of our busy, technologically-driven lives, it is taken for granted that we respond to minor fluctuations in our health by taking pills ż pills for headache and for toothache; sleeping pills and tranquilizers; pills to lower fever, quiet coughs, and clear the sinuses; medicines to reduce appetite; preparations to relieve heartburn; and many more. In the war against serious disease, medicines are an indispensable weapon in the physician's arsenal: they save lives, or at least prolong them and make them more bearable. Despite the important role that pharmaceuticals play in our lives, few of us know where medicines come from or how the pharmaceutical industry discovers and develops new drugs. Jürgen Drews, an acclaimed leader in the pharmaceutical industry, tells the fascinating story of drug discovery and development from his years of successfully leading international research teams at Hoffman-LaRoche. Drews traces the history of modern drug development from pharmacies, chemical companies, and individual entrepreneurs in Switzerland, Germany and the U.S. to the mega-corporations that dot the landscape of Europe, Japan and America. He describes the process by which new drugs are tested and brought to market, including a provocative look at how AIDS activism stimulated the approval process in the U.S. Drews' commentary on the role of clinical trials ż the time involved and their cost ż is sobering testimony to the complexity of bringing innovation to the marketplace. In the final two chapters of 'In Quest of Tomorrow's Medicines', Drews offers an important and critical analysis of research in the pharmaceutical industry, pointing to strategies that work and management practices that impede progress.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.

  • Alvio Renzini

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540002057 ISBN 13: 9783540002055

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    Buch. Condition: Neu. Neuware -Measuring the masses of galaxies as a function of redshift is perhaps one of the most challenging open issues in current astronomical research. The evolution of the baryonic and dark matter components of galaxies is not only a critical test of the hierarchical formation paradigm, but ultimately also provides new clues on the complex interplay between star formation, the cooling and heating of gas and galaxy merging processes.This book reviews current techniques to measure the baryonic (stellar) and dark masses of nearby galaxies, and focusses on ongoing attempts to measure these same quantities in galaxies at higher and higher redshifts. It also gives room to future perspectives, with special emphasis on new survey projects and satellite missions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

  • Shahar Mendelson

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540005293 ISBN 13: 9783540005292

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    Taschenbuch. Condition: Neu. Neuware -Machine Learning has become a key enabling technology for many engineering applications and theoretical problems alike. To further discussions and to dis- minate new results, a Summer School was held on February 11ż22, 2002 at the Australian National University. The current book contains a collection of the main talks held during those two weeks in February, presented as tutorial chapters on topics such as Boosting, Data Mining, Kernel Methods, Logic, Reinforcement Learning, and Statistical Learning Theory. The papers provide an in-depth overview of these exciting new areas, contain a large set of references, and thereby provide the interested reader with further information to start or to pursue his own research in these directions. Complementary to the book, a recorded video of the presentations during the Summer School can be obtained at mlg. anu. edu. au/summer2002 It is our hope that graduate students, lecturers, and researchers alike will nd this book useful in learning and teaching Machine Learning, thereby continuing the mission of the Summer School. Canberra, November 2002 Shahar Mendelson Alexander Smola Research School of Information Sciences and Engineering, The Australian National University Thanks and Acknowledgments We gratefully thank all the individuals and organizations responsible for the success of the workshop.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 276 pp. Englisch.

  • Book 76 of 126: Lecture Notes in Economics and Mathematical Systems

    Stefan Spinler

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540002871 ISBN 13: 9783540002871

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    Taschenbuch. Condition: Neu. Neuware -Arguably the central problem in operations research and management science (OR/MS) addressed by e-Business is better coordination of supply and de mand, including price discovery and reduction of transactions costs of buyer seller interactions. In capital-intensive industries like chemicals and steel, the out-of-pocket costs of excess capacity and the opportunity costs of underuti lized capacity have been important factors driving the growth of exchanges for improving demand and supply coordination through e-Business platforms. Stefan Spinler addresses in his dissertation one of the most interesting aspects of this evolution for OR/MS, the parallel development of long-term and short-term markets for capacity and output, accompanied by a range of exotic options and forwards as the basic mechanisms supporting transac tions. This is a fascinating research topic because it builds on the powerful framework of real options, while connecting directly to key operations deci sions (capacity planning, staffing, maintenance, and so forth) of the plants and technologies whose output is the focus of contracts. From the perspec tive of practice, the use of these contracting mechanisms, as facilitated by a new breed of B2B exchanges, represents an opportunity for further improving supply chain performance and capital asset productivity.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 160 pp. Englisch.

  • Derick Wood

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540004009 ISBN 13: 9783540004004

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    Taschenbuch. Condition: Neu. Neuware -TheCIAAconferenceseriesprovidesaforumforthenewproblemsand challenges. Intheseconferences,boththeoreticalandpracticalresultsrelatedto theapplicationandimplementationofautomatawerepresentedanddiscussed, andsoftwarepackagesandtoolkitsweredemonstrated. Theparticipantsofthe conferenceserieswerefrombothresearchinstitutionsandindustry. Wethankalloftheprogramcommitteemembersandrefereesfortheire orts inrefereeingandselectingpapers. Thisvolumewaseditedwithmuchhelpfrom NanetteSaesandHannekeDriever,whiletheconferenceitselfwasrunsmoothly withthehelpofElmarieWillemse,NanetteSaes,andTheoKoopman. VI Foreword WealsowishtothanktheSouthAfricanNRF(forfundingairfares)andthe DepartmentofComputerScience,UniversityofPretoria,fortheir nancialand logisticsupportoftheconference. WealsothanktheeditorsoftheLectureNotes inComputerScienceseriesandSpringer-Verlag,inparticularAnnaKramer,for theirhelpinpublishingthisvolume. October2002 BruceW. Watson DerickWood CIAA 2001 Program Committee BernardBoigelot UniversitżedeLiege,Belgium Jean-MarcChamparnaud UniversitżedeRouen,France MaximeCrochemore UniversityofMarne-la-Vallżee,France OscarIbarra UniversityofCaliforniaatSantaBarbara,USA LauriKarttunen XeroxPaloAltoResearchCenter,USA NilsKlarlund AT&TLaboratories,USA DenisMaurel UniversitżedeTours,France MehryarMohri AT&TLaboratories,USA Jean-EricPin UniversitżeParis7,France KaiSalomaa QueenżsUniversity,Canada HelmutSeidl TrierUniversity,Germany BruceWatson(Chair) UniversityofPretoria,SouthAfrica EindhovenUniversity,TheNetherlands DerickWood(Co-chair) HongKongUniversityofScience andTechnology,China ShengYu UniversityofWesternOntario,Canada Table of Contents UsingFiniteStateTechnologyinNaturalLanguageProcessingofBasque. . . 1 IżnakiAlegria,MaxuxAranzabe,NereaEzeiza,AitzolEzeiza, andRubenUrizar CascadeDecompositionsareBit-VectorAlgorithms. . . . . . . . . . . . . . . . . . . . . . . . 13 AnneBergeronandSylvieHamel SubmoduleConstructionandSupervisoryControl:AGeneralization. . . . . . . 27 GregoSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 304 pp. Englisch.

  • Vincenzo Capasso

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540002952 ISBN 13: 9783540002956

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    Taschenbuch. Condition: Neu. Neuware -The theory of stochastic processes indexed by a partially ordered set has been the subject of much research over the past twenty years. The objective of this CIME International Summer School was to bring to a large audience of young probabilists the general theory of spatial processes, including the theory of set-indexed martingales and to present the different branches of applications of this theory, including stochastic geometry, spatial statistics, empirical processes, spatial estimators and survival analysis. This theory has a broad variety of applications in environmental sciences, social sciences, structure of material and image analysis. In this volume, the reader will find different approaches which foster the development of tools to modelling the spatial aspects of stochastic problems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 268 pp. Englisch.

  • Alexei Fridman

    Language: English

    Published by Springer Netherlands, Springer Netherlands Jan 2003, 2003

    ISBN 10: 1402009356 ISBN 13: 9781402009358

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    Buch. Condition: Neu. Neuware -On August 2000 in the Lomonosov Moscow State University the first scientific conference dedicated to chaos in the real astronomical systems was held. The most prominent astrophysisists - specialist in the field of stochastic dynamics - attended the conference. A broad scope of the problems related to the observed manifes tations of chaotic motions in galactic and stellar objects, with the involvement of basic theory and numerical modeling, were addressed. The idea (not so obvious, as we believe, to many astrophysicists) was to show that, while great progress in the field of stochastic mechanics was accomplished, the science of chaos in actually observed systems is only just being born. Basically, the situation described prompted the organizers to hold the meeting in order to discuss chaotic processes in real systems. It seemed worthwhile to begin these introductory remarks with a brief descrip tion of some events that preceeded the conference. Since actually existing systems are the subject of the natural sciences, and in the latter experiments play the key role, we shall begin our account with the experimental results.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

  • Burton S. Jr. Kaliski

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540004092 ISBN 13: 9783540004097

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    Taschenbuch. Condition: Neu. Neuware -ThesearetheproceedingsofCHES2002,theFourthWorkshoponCryptographic Hardware and Embedded Systems. After the rst two CHES Workshops held in Massachusetts, and the third held in Europe, this is the rst Workshop on the West Coast of the United States. There was a record number of submissions this year and in response the technical program was extended to 3 days. As is evident by the papers in these proceedings, there have been again many excellent submissions. Selecting the papers for this yearżs CHES was not an easy task, and we regret that we could not accept many contributions due to the limited availability of time. There were 101 submissions this year, of which 39 were selected for presentation. We continue to observe a steady increase over previous years: 42 submissions at CHES ż99, 51 at CHES 2000, and 66 at CHES 2001. We interpret this as a continuing need for a workshop series that c- bines theory and practice for integrating strong security features into modern communicationsandcomputerapplications. Inadditiontothesubmittedcont- butions, Jean-Jacques Quisquater (UCL, Belgium), Sanjay Sarma (MIT, USA) and a panel of experts on hardware random number generation gave invited talks. As in the previous years, the focus of the Workshop is on all aspects of cr- tographic hardware and embedded system security. Of special interest were c- tributionsthatdescribenewmethodsfore cienthardwareimplementationsand high-speed software for embedded systems, e. g. , smart cards, microprocessors, DSPs, etc. CHES also continues to be an important forum for new theoretical and practical ndings in the important and growing eld of side-channel attacks. 632 pp. Englisch.

  • Book 28 of 94: Applied Mathematical Sciences

    Bernard Chalmond

    Language: English

    Published by Springer New York, Springer US Jan 2003, 2003

    ISBN 10: 038795547X ISBN 13: 9780387955476

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    Buch. Condition: Neu. Neuware -More mathematicians have been taking part in the development of digital image processing as a science and the contributions are reflected in the increasingly important role modeling has played solving complex problems. This book is mostly concerned with energy-based models. Through concrete image analysis problems, the author develops consistent modeling, a know-how generally hidden in the proposed solutions. The book is divided into three main parts. The first two parts describe the materials necessary to the models expressed in the third part. These materials include splines (variational approach, regression spline, spline in high dimension), and random fields (Markovian field, parametric estimation, stochastic and deterministic optimization, continuous Gaussian field). Most of these models come from industrial projects in which the author was involved in robot vision and radiography: tracking 3D lines, radiographic image processing, 3D reconstruction and tomography, matching, deformation learning. Numerous graphical illustrations accompany the text showing the performance of the proposed models. This book will be useful to researchers and graduate students in applied mathematics, computer vision, and physics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

  • Book 16 of 19: Information Technology: Transmission, Processing and Storage

    Steven A. Tretter

    Language: English

    Published by Springer US, Springer US Jan 2003, 2003

    ISBN 10: 0306474298 ISBN 13: 9780306474293

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    Taschenbuch. Condition: Neu. Neuware -Designed for senior electrical engineering students, this textbook explores the theoretical concepts of digital signal processing and communication systems by presenting laboratory experiments using real-time DSP hardware. The experiments are designed for the Texas Instruments TMS320C6701 Evaluation Module or TMS320C6711 DSK but can easily be adapted to other DSP boards. Each chapter begins with a presentation of the required theory and concludes with instructions for performing experiments to implement the theory. In the process of performing the experiments, students gain experience in working with software tools and equipment commonly used in industry.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 328 pp. Englisch.

  • Clara Pinto-Correia

    Language: English

    Published by Springer New York Jan 2003, 2003

    ISBN 10: 0387988769 ISBN 13: 9780387988764

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    Buch. Condition: Neu. Neuware - Although everybody is familiar with the dodo bird, very few people know its history. Yet this history is compelling when read as a fable of the negative impact of humans on Earth's ecosystems. The author describes the complexity of the factors involved in animal extinction. Although we think of ourselves as more ecologically aware than our ancestors, we are propelling extinction to alarming rates.

  • Book 15 of 165: Undergraduate Texts in Mathematics

    László Lovász

    Language: English

    Published by Springer New York, Springer US Jan 2003, 2003

    ISBN 10: 0387955844 ISBN 13: 9780387955841

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    Buch. Condition: Neu. Neuware -Discrete mathematics is quickly becoming one of the most important areas of mathematical research, with applications to cryptography, linear programming, coding theory and the theory of computing. This book is aimed at undergraduate mathematics and computer science students interested in developing a feeling for what mathematics is all about, where mathematics can be helpful, and what kinds of questions mathematicians work on. The authors discuss a number of selected results and methods of discrete mathematics, mostly from the areas of combinatorics and graph theory, with a little number theory, probability, and combinatorial geometry. Wherever possible, the authors use proofs and problem solving to help students understand the solutions to problems. In addition, there are numerous examples, figures and exercises spread throughout the book. Laszlo Lovasz is a Senior Researcher in the Theory Group at Microsoft Corporation. He is a recipient of the 1999 Wolf Prize andthe Godel Prize for the top paper in Computer Science. Jozsef Pelikan is Professor of Mathematics in the Department of Algebra and Number Theory at Eotvos Lorand University, Hungary. In 2002, he was elected Chairman of the Advisory Board of the International Mathematical Olympiad. Katalin Vesztergombi is Senior Lecturer in the Department of Mathematics at the University of Washington.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

  • Book 15 of 165: Undergraduate Texts in Mathematics

    László Lovász

    Language: English

    Published by Springer New York Jan 2003, 2003

    ISBN 10: 0387955852 ISBN 13: 9780387955858

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    Taschenbuch. Condition: Neu. Neuware - Discrete mathematics is quickly becoming one of the most important areas of mathematical research, with applications to cryptography, linear programming, coding theory and the theory of computing. This book is aimed at undergraduate mathematics and computer science students interested in developing a feeling for what mathematics is all about, where mathematics can be helpful, and what kinds of questions mathematicians work on. The authors discuss a number of selected results and methods of discrete mathematics, mostly from the areas of combinatorics and graph theory, with a little number theory, probability, and combinatorial geometry. Wherever possible, the authors use proofs and problem solving to help students understand the solutions to problems. In addition, there are numerous examples, figures and exercises spread throughout the book. Laszlo Lovasz is a Senior Researcher in the Theory Group at Microsoft Corporation. He is a recipient of the 1999 Wolf Prize andthe Godel Prize for the top paper in Computer Science. Jozsef Pelikan is Professor of Mathematics in the Department of Algebra and Number Theory at Eotvos Lorand University, Hungary. In 2002, he was elected Chairman of the Advisory Board of the International Mathematical Olympiad. Katalin Vesztergombi is Senior Lecturer in the Department of Mathematics at the University of Washington.

  • Book 77 of 165: Undergraduate Texts in Mathematics

    Janos Suranyi

    Language: English

    Published by Springer New York Jan 2003, 2003

    ISBN 10: 0387953205 ISBN 13: 9780387953205

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    Buch. Condition: Neu. Neuware - Number theory, the branch of mathematics which studies the properties of the integers, is a repository of interesting and quite varied problems, sometimes impossibly difficult ones. The authors have gathered together a collection of problems from various topics in number theory that they find beautiful, intriguing, and from a certain point of view instructive. In addition to revealing the beauty of the problems themselves, they have tried to give glimpses into deeper, related mathematics. The book presents problems whose solutions can be obtained using elementary methods. No prior knowledge of number theory is assumed.

  • Josef Pieprzyk

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540431012 ISBN 13: 9783540431015

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    Buch. Condition: Neu. Neuware -This reference work looks at modern concepts of computer security. It introduces the basic mathematical background necessary to follow computer security concepts before moving on to modern developments in cryptography. The concepts are presented clearly and illustrated by numerous examples. Subjects covered include: private-key and public-key encryption, hashing, digital signatures, authentication, secret sharing, group-oriented cryptography, and many others. The section on intrusion detection and access control provide examples of security systems implemented as a part of operating system. Database and network security is also discussed. The final chapters introduce modern e- business systems based on digital cash.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 700 pp. Englisch.

  • Florian Leiner

    Language: English

    Published by Springer New York, Springer US Jan 2003, 2003

    ISBN 10: 0387951598 ISBN 13: 9780387951591

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    Taschenbuch. Condition: Neu. Neuware -Medical Data Management is a systematic introduction to the basicmethodology of professional clinical data management. It emphasizesgeneric methods of medical documentation applicable to such diversetasks as the electronic patient record, maintaining a clinical trialsdatabase, and building a tumor registry. This book is for all studentsin medical informatics and health information management, and it isideal for both the undergraduate and the graduate levels. The bookalso guides professionals in the design and use of clinicalinformation systems in various health care settings. It is aninvaluable resource for all health care professionals involved indesigning, assessing, adapting, or using clinical data managementsystems in hospitals, outpatient clinics, study centers, health plansetc.The book combines a consistent theoretical foundation of medicaldocumentation methods outlining their practical applicability in realclinical data management systems. Two new chapters detail hospitalinformation systems and clinical trials. There is a focus on theinternational classification of diseases (ICD-9 and -10) systems, aswell as a discussion on the difference between the two codes. Allchapters feature exercises, bullet points, and a summary to providethe reader with essential points to remember. New to the Third Editionis a comprehensive section comprised of a combined Thesaurus andGlossary which aims to clarify the unclear and sometimes inconsistentterminology surrounding the topic.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

  • W J Nijhof

    Language: English

    Published by Springer Jan 2003, 2003

    ISBN 10: 1402011466 ISBN 13: 9781402011467

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    Taschenbuch. Condition: Neu. Neuware - Flexibility seems to be the core concept of economic and educational change in our time. The promise of solutions to many problems at the individual, institutional, and national level evokes as much controversy as acclaim. This might be related to the different perspectives of actors and researchers involved in problem-solving in Vocational Education and Training (VET), where, on the one hand, solutions should be sought in key qualifications and transferability, in changing teaching and learning processes, while, on the other, political, institutional, organisational, and professional conditions are seen as the key interventions to build a responsive workforce on the basis of a re-engineered VET system. Consequently, flexibility in connection with vocational education and training and the labour market has several divergent connotations.

  • Bruce West

    Language: English

    Published by Springer New York Jan 2003, 2003

    ISBN 10: 0387955542 ISBN 13: 9780387955544

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    Buch. Condition: Neu. Neuware - In Chapter One we review the foundations of statistieal physies and frac tal functions. Our purpose is to demonstrate the limitations of Hamilton's equations of motion for providing a dynamical basis for the statistics of complex phenomena. The fractal functions are intended as possible models of certain complex phenomena; physical.systems that have long-time mem ory and/or long-range spatial interactions. Since fractal functions are non differentiable, those phenomena described by such functions do not have dif ferential equations of motion, but may have fractional-differential equations of motion. We argue that the traditional justification of statistieal mechan ics relies on aseparation between microscopic and macroscopie time scales. When this separation exists traditional statistieal physics results. When the microscopic time scales diverge and overlap with the macroscopie time scales, classieal statistieal mechanics is not applicable to the phenomenon described. In fact, it is shown that rather than the stochastic differential equations of Langevin describing such things as Brownian motion, we ob tain fractional differential equations driven by stochastic processes.

  • Book 4 of 19: Graduate Texts in Contemporary Physics

    Boris M Smirnov

    Language: English

    Published by Springer New York Jan 2003, 2003

    ISBN 10: 038795550X ISBN 13: 9780387955506

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    Buch. Condition: Neu. Neuware - Intended for advanced students of physics, chemistry, and related disciplines, this text treats the quantum theory of atoms and ions within the framework of self-consistent fields. It treats the structure and spectra of atoms and ions, their behavior in external fields, and their interactions, including collisions. Data needed for the analysis of collisions and other atomic processes are also included, making the book useful as a reference for researchers as well as students. In the main text, simple and convincing methods are used to explain the fundamental properties of atoms, molecules, and clusters; details and more advanced aspects of these topics are treated in the problems at the end of each chapter. The first part of the book is devoted to properties of atoms and ions considered as quantum systems of electrons orbiting a heavy Coulomb center. Self-consistent fields and the shell model give a logical and consistent picture, and provide reliable models for the analysis of atomic properties. The second part deals with interactions and collisions of particles -- including bound systems, such as molecules, clusters, and solids. The aim here is to relate the internal structure of the atoms to the interactions between them, providing useful insights for applications; the accompanying data in tables, charts, and spectra complement the theoretical discussion.

  • David D Yao

    Language: English

    Published by Springer New York Jan 2003, 2003

    ISBN 10: 0387955828 ISBN 13: 9780387955827

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    Buch. Condition: Neu. Neuware - The objective of this volume is to highlight through a collection of chap ters some of the recent research works in applied prob ability, specifically stochastic modeling and optimization. The volume is organized loosely into four parts. The first part is a col lection of several basic methodologies: singularly perturbed Markov chains (Chapter 1), and related applications in stochastic optimal control (Chapter 2); stochastic approximation, emphasizing convergence properties (Chapter 3); a performance-potential based approach to Markov decision program ming (Chapter 4); and interior-point techniques (homogeneous self-dual embedding and central path following) applied to stochastic programming (Chapter 5). The three chapters in the second part are concerned with queueing the ory. Chapters 6 and 7 both study processing networks - a general dass of queueing networks - focusing, respectively, on limit theorems in the form of strong approximation, and the issue of stability via connections to re lated fluid models. The subject of Chapter 8 is performance asymptotics via large deviations theory, when the input process to a queueing system exhibits long-range dependence, modeled as fractional Brownian motion.

  • Carl Davidson

    Language: English

    Published by Springer Netherlands, Springer Netherlands Jan 2003, 2003

    ISBN 10: 140207333X ISBN 13: 9781402073335

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    Buch. Condition: Neu. Neuware -Search Theory and Unemployment contains nine chapters that survey and extend the theory of job search and its application to the problem of unemployment. The volume ranges from surveys of job search theory that take microeconomic and macroeconomic perspectives to original theoretical contributions which focus on the externalities arising from non-sequential search and search under imperfect information. It includes a clear and authoritative survey of econometric methods that have been developed to estimate models of job search, as well as two lucid contributions to the empirical search literature. Finally, it includes a study that reviews and extends the literature on optimal unemployment insurance and concludes with an appraisal of the influence of search theory on the thinking of macroeconomic policymakers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

  • Waltraud Rücker

    Language: English

    Published by Springer Vienna, Springer Vienna Jan 2003, 2003

    ISBN 10: 3211838392 ISBN 13: 9783211838396

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    Taschenbuch. Condition: Neu. Neuware -In 2002 the 100th anniversary of the publication on 'Culturversuche mit isolierten Pflanzenzellen' by Gottlieb Haberlandt was celebrated. Haberlandtżs vision of the totipotency of plant cells represents the actual beginning of tissue culture. This book pays homage to a great Austrian scientist and the further development of his ideas.The first part of the book contains a facsimile of the original paper which is a true artistic masterpiece and its first translation into English from 1969. The second and third parts describe Haberlandtżs life and work and early historical aspects of the development of plant tissue culture.The fourth part of the book contains an overview of important topics of plant tissue culture with the most promising areas of application to date and an outlook into the future. Areas range from micropropagation, production of pharmaceutically interesting compounds, plant breeding, genetic engineering of crop plants, including trees, and cryopreservation of valuable germplasm.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 276 pp. Englisch.

  • Norbert Müller

    Language: English

    Published by Springer Vienna, Springer Vienna Jan 2003, 2003

    ISBN 10: 3211838945 ISBN 13: 9783211838945

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    Buch. Condition: Neu. Neuware -Why to apply solid-state NMR - By now, we should have learned that NMR is mainly used for the study of molecules in solution, while x-ray diffraction is the method of choice for solids. Based on this fact, the two recent 'NMR-Nobelprizes' went indeed into the liquid phase: my own one eleven years ago, and particularly the most recent one to Kurt Wuthrich. His prize is beyond any doubts very well justified. His contribution towards the study of biomolecules in solution, in their native (or almost native) environment is truly monumental. We all will profit from it indirectly when one of our future diseases will be cured with better drugs, based on the insightful knowledge gained through liquid-state NMR. Two fields of NMR are still left out of the Nobel Prize game: magnetic reso nance imaging (MRI) and solid-state NMR. The disrespect for MRI in Stockholm is particularly difficult to understand; but this is not a subject to be discussed at the present place. Solid-state NMR is the third of the three great fields of NMR, powerful already today and very promising for the near future.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

  • Book 123 of 544: Advances in Experimental Medicine and Biology

    Chaim Hershko

    Language: English

    Published by Springer US, Springer US Jan 2003, 2003

    ISBN 10: 0306467852 ISBN 13: 9780306467851

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    Buch. Condition: Neu. Neuware -Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 288 pp. Englisch.

  • Y. R. Talpaert

    Language: English

    Published by Springer Netherlands, Springer Netherlands Jan 2003, 2003

    ISBN 10: 1402010559 ISBN 13: 9781402010552

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    Buch. Condition: Neu. Neuware -This book is designed for students in engineering, physics and mathematics. The material can be taught from the beginning of the third academic year. It could also be used for self study, given its pedagogical structure and the numerous solved problems which prepare for modem physics and technology. One of the original aspects of this work is the development together of the basic theory of tensors and the foundations of continuum mechanics. Why two books in one Firstly, Tensor Analysis provides a thorough introduction of intrinsic mathematical entities, called tensors, which is essential for continuum mechanics. This way of proceeding greatly unifies the various subjects. Only some basic knowledge of linear algebra is necessary to start out on the topic of tensors. The essence of the mathematical foundations is introduced in a practical way. Tensor developments are often too abstract, since they are either aimed at algebraists only, or too quickly applied to physicists and engineers. Here a good balance has been found which allows these extremes to be brought closer together. Though the exposition of tensor theory forms a subject in itself, it is viewed not only as an autonomous mathematical discipline, but as a preparation for theories of physics and engineering. More specifically, because this part of the work deals with tensors in general coordinates and not solely in Cartesian coordinates, it will greatly help with many different disciplines such as differential geometry, analytical mechanics, continuum mechanics, special relativity, general relativity, cosmology, electromagnetism, quantum mechanics, etc .Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 612 pp. Englisch.

  • Book 55 of 130: Medical Radiology

    Robert Hermans

    Language: English

    Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

    ISBN 10: 3540002499 ISBN 13: 9783540002499

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    Taschenbuch. Condition: Neu. Neuware -Notwithstanding the important role of direct clinical and endoscopic examination in modern management of pathological conditions of the larynx, radiological study the and, more specifically, cross-sectional imaging by CT and MRI make definite diagnostic contributions by virtue of their potential to display superbly the deeper extent of laryngeal lesions. Indeed, remarkable progress has been achieved during recent years in CT and MRI techniques as applied to the neck region. This book sets out to provide a sorely needed update of our knowledge of the diagnostic potential of these cross-sectional methods and constitutes a very welcome addition to our series 'Medical Radiology', which aims to cover all important clinical imaging fields of modern diagnostic radiology. It will be of great interest to general and head and neck radiologists as well as to ENT surgeons and radiotherapists. Professor R. Hermans and the other distinguished contributors to this work are internationally renowned experts in the field and they have accumulated vast experi ence and a wealth of radio-pathological knowledge of the larynx over the years. I would like to congratulate them most sincerely for this outstanding volume, its comprehensive contents and its superb illustrations. I hope that this book will meet with the same great success as previously published volumes in the series. I would appreciate any constructive criticism that might be offered.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 208 pp. Englisch.

  • Paolo Rocchi

    Language: English

    Published by Springer US, Springer US Jan 2003, 2003

    ISBN 10: 030647428X ISBN 13: 9780306474286

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    Buch. Condition: Neu. Neuware -The Structural Theory of Probability addresses the interpretation of probability, often debated in the scientific community. This problem has been examined for centuries; perhaps no other mathematical calculation suffuses mankind's efforts at survival as amply as probability. In the dawn of the 20th century David Hilbert included the foundations of the probability calculus within the most vital mathematical problems; Dr. Rocchi's topical and ever-timely volume proposes a novel, exhaustive solution to this vibrant issue.Paolo Rocchi, a versatile IBM scientist, outlines a new philosophical and mathematical approach inspired by well-tested software techniques. Through the prism of computer technology he provides an innovative view on the theory of probability. Dr. Rocchi discusses in detail the mathematical tools used to clarify the meaning of probability, integrating with care numerous examples and case studies. The comprehensiveness and originality of its mathematical development make this volume an inspiring read for researchers and students alike.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 176 pp. Englisch.

  • F. Zapata

    Language: English

    Published by Springer Netherlands, Springer Netherlands Jan 2003, 2003

    ISBN 10: 1402010419 ISBN 13: 9781402010415

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    Buch. Condition: Neu. Neuware -This publication deals with soil erosion and sedimentation. Soil erosion and associated sediment deposition are natural landscape-forming processes that can be greatly accelerated by human intervention through deforestation, overgrazing, and non-sustainable farming practices. Soil erosion and sedimentation may not only cause on-site degradation of the natural resource base, but also off-site problemsż downstream sediment deposition in fields, floodplains and water bodies, water pollution, eutrophication and reservoir siltation, etc. żwith serious environmental and economic impairment. There is an urgent need for accurate information to quantify the problem and to underpin the selection of effective soil-conservation technologies and sedimentation-remediation strategies, including assessment of environmental and economic impacts. Existing classical techniques to document soil erosion are capable of meeting some of these needs, but they all possess important limitations. The quest for alternative techniques for assessing soil erosion, to complement existing methods, directed attention to the use of environmental radionuclides, in particular fallout as tracers to quantify rates and establish patterns of soil redistribution within the landscape. The concept of a project on the use of environmental radionuclides to quantify soil redistribution was first formulated at an Advisory Group Meeting convened in Vienna, April 1993, by the International Atomic Energy Agency (IAEA).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

  • Bilge Saruhan

    Language: English

    Published by Springer US, Springer New York Jan 2003, 2003

    ISBN 10: 1402073496 ISBN 13: 9781402073496

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    Buch. Condition: Neu. Neuware -The purpose of Oxide-Based Fiber-Reinforced Ceramic-Matrix Composites is to provide comprehensive information on the most recent successful findings. The book consists of six chapters which characterize the current state of the art concerning oxide-based fiber-reinforced composites.Chapter one provides an introduction, examples of application areas and background information. Chapter two deals with the primary material properties for the areas of application and lists the possible constituent parts of the composites, depending on particular demands. Chapter three explains both the past and present fabrication methods which can affect the performance of the composites. Chapter four defines the interphase-related phenomena and describes the mechanical characteristics of the oxide-based fiber-reinforced composite, produced with different interphases. Chapter five deals with the fabrication route, functionality and mechanical characterization of the porous-matrix composites. The last chapter summarizes the present achievements and identifies requirements for reaching the goal, thereby providing a promising course for future research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

  • Dan Corbett

    Language: English

    Published by Springer US, Springer US Jan 2003, 2003

    ISBN 10: 0306474875 ISBN 13: 9780306474873

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    Buch. Condition: Neu. Neuware -Reasoning and Unification over Conceptual Graphs is an exploration of automated reasoning and resolution in the expanding field of Conceptual Structures. Designed not only for computing scientists researching Conceptual Graphs, but also for anyone interested in exploring the design of knowledge bases, the book explores what are proving to be the fundamental methods for representing semantic relations in knowledge bases. While it provides the first comprehensive treatment of Conceptual Graph unification and reasoning, the book also addresses fundamental issues of graph matching, automated reasoning, knowledge bases, constraints, ontology and design. With a large number of examples, illustrations, and both formal and informal definitions and discussions, this book is excellent as a tutorial for the reader new to Conceptual Graphs, or as a reference book for a senior researcher in Artificial Intelligence, Knowledge Representation or Automated Reasoning.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 168 pp. Englisch.