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ISBN 10: 1032922052 ISBN 13: 9781032922058
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Paperback. Condition: new. Paperback. Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimers disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase IIIII trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel. Written by leading pioneers of Bayesian clinical trial designs, this book explores the growing role of Bayesian thinking in clinical trial analysis. Covering Phase I, II, and III clinical trials, it establishes the basic principles before extending them to specific phases and endpoints. The authors also discuss special topics that span different Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
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ISBN 10: 1032922052 ISBN 13: 9781032922058
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Add to basketPaperback. Condition: new. Paperback. Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimers disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase IIIII trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel. Written by leading pioneers of Bayesian clinical trial designs, this book explores the growing role of Bayesian thinking in clinical trial analysis. Covering Phase I, II, and III clinical trials, it establishes the basic principles before extending them to specific phases and endpoints. The authors also discuss special topics that span different Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.
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Add to basketCondition: New. Scott M. Berry is the President and Senior Statistical Scientist at Berry Consultants, a statistical consulting group specializing in adaptive clinical trial design in pharmaceutical and medical device research and development.
Published by Taylor & Francis Ltd, London, 2024
ISBN 10: 1032922052 ISBN 13: 9781032922058
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Add to basketPaperback. Condition: new. Paperback. Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimers disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase IIIII trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel. Written by leading pioneers of Bayesian clinical trial designs, this book explores the growing role of Bayesian thinking in clinical trial analysis. Covering Phase I, II, and III clinical trials, it establishes the basic principles before extending them to specific phases and endpoints. The authors also discuss special topics that span different Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Published by CRC Press 2010-07-22, 2010
ISBN 10: 1439825483 ISBN 13: 9781439825488
Language: English
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Add to basketHardcover. Condition: Brand New. 1st edition. 305 pages. 9.50x6.25x1.00 inches. In Stock.
Published by CRC Press, 2011
ISBN 10: 1439825483 ISBN 13: 9781439825488
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Add to basketHardback. Condition: Fine. No Jacket. Circa 2011. Nearly fine condition with no wrapper. Chapman & Hall/CRC Biostatistics Series. For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. Blue glazed boards. Boards a little scuffed, remains of label to rear board. Binding error to rear pastedown and endpaper which means the pastedown is creased vertically and last page of index is stuck to the pastedown. Contents otherwise fine. Packaged with care and promptly dispatched!