Gene Expression Muscle (31 results)

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Taschenbuch. Condition: Neu. Lysophosphatidic Acid Induction Of Tissue Factor Gene Expression | A Molecular Study In Vascular Smooth Muscle Cells | Essam Laag | Taschenbuch | 96 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838381374 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. …

Kartoniert / Broschiert. Condition: New. The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, t.

Taschenbuch. Condition: Neu. Regulatory Networks of Gene Expression in Heart and Skeletal Muscle Cells | The Role of Histone Modifications and Transcription Factors in Muscle Cell Development and Maintenance | Jenny J. Fischer | Taschenbuch | Kartoniert / Broschiert | Englisch | 2013 | VDM Verlag Dr. Müller | EAN 9783836483735 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.…

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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression. In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modifications and their potential interactions with key cardiac transcription factors in the context of muscle development and congenital heart diseases are presented. Several hundred genes regulated by the transcription factors Gata4, Mef2a, Nkx2.5, and Srf were identified, demonstrating their essential role in the formation of cardiac structures. The findings support the existence of a complex combinatorial 'histone code' and suggest that histone modifications have further functions as signaling marks. This book is addressed to researchers in a modern molecular biology laboratory, including the fields of biology, biochemistry, bioinformatics, and medicine.; The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression.In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modifications and their potential interactions with key cardiac transcription factors in the context of muscle development and congenital heart diseases are presented. Several hundred genes regulated by the transcription factors Gata4, Mef2a, Nkx2.5, and Srf were identified, demonstrating their essential role in the formation of cardiac structures. The findings support the existence of a complex combinatorial 'histone code' and suggest that histone modifications have further functions as signaling marks.This book is addressed to researchers in a modern molecular biology laboratory, including the fields of biology, biochemistry, bioinformatics, and medicine.…

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - LPA is a component of oxidized low density lipoproteins (oxLDL) which has been shown to accumulate in human atherosclerotic plaques. Tissue factor (TF) is the principal initiator of blood coagulation. Tissue factor upregulation in atherosclerotic plaque can lead to undesirable vascular thrombosis. The generation of reactive oxygen species (ROS), which act as signaling molecules in the vascular system, is enhanced in response to injury and has been associated with a procoagulant state and the progression of atherosclerotic disease. Oxidative stress might contribute to the increased expression of pro atherosclerotic genes at sites of vascular injury, including TF. Little is known about the regulation of TF by LPA in smooth muscle cells (SMC) which is a major player in the process of atherosclerosis. Data generated by this study demonstrate that LPA markedly induces TF expression in rat aorta smooth muscle cells (RASMCs) and human aorta smooth muscle cells (HASMCs). The signaling pathways involved are multiple.…

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