Polyglutamine Disorders (21 results)
Language: English
Published by Springer, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
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Published by Springer International Publishing, 2019
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Published by Springer, 2019
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently being e…xplored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
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Published by Springer, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Softcover
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Taschenbuch. Condition: Neu. Polyglutamine Disorders | Clévio Nóbrega (u. a.) | Taschenbuch | Advances in Experimental Medicine and Biology | viii | Englisch | 2019 | Springer | EAN 9783319891033 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]c…om | Anbieter: preigu.
Language: English
Published by Springer Verlag, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
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Paperback. Condition: Brand New. reprint edition. 480 pages. 9.25x6.10x0.94 inches. In Stock.
Language: English
Published by Springer, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
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Language: English
Published by Springer, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
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Language: English
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Language: English
Published by Springer International Publishing Jun 2019, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are c…urrently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression. 480 pp. Englisch.
Language: English
Published by Springer, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Softcover
- Print on Demand
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Condition: New. Print on Demand pp. 469.
Language: English
Published by Springer, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
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Condition: New. PRINT ON DEMAND pp. 469.
Language: English
Published by Springer, Springer Jun 2019, 2019
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Softcover
- Print on Demand
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies¿ development and progression, and (2) the therapeutic strategies that are curre…ntly being explored to stop or delay disease progression.Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington¿s disease (HD); spinal¿bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 480 pp. Englisch.
Language: English
Published by Springer International Publishing Feb 2018, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print on Demand
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currentl…y being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression. 480 pp. Englisch.
Language: English
Published by Palgrave Macmillan, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print on Demand
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Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently bei…ng explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Language: English
Published by Springer, Springer Feb 2018, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print on Demand
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
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Buch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies¿ development and progression, and (2) the therapeutic strategies that are currently be…ing explored to stop or delay disease progression.Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington¿s disease (HD); spinal¿bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 480 pp. Englisch.
Language: English
Published by Springer, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print on Demand
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Condition: New. Print on Demand.
Language: English
Published by Springer, 2018
Series: Book 345 of 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print on Demand
Seller: Biblios, frankfurt am main, HESSE, GermanyBiblios
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