Rna Interference Pathways (17 results)

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Taschenbuch. Condition: Neu. RNA interference pathways in the moss Physcomitrella patens | The regulatory role of small RNAs in the moss Physcomitrella patens | Basel Khraiwesh | Taschenbuch | 128 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783844325188 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

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Hardcover. Condition: new. Hardcover. One of the most important breakthroughs of the 20th century was the discovery of how short RNA molecules from the genomic "dark matter" can control invasive genetic elements or fine-tune endogenous gene expression. The collective name of these pathways is RNA interference (RNAi), or "gene silencing", and the main players here are short, single-stranded RNA molecules in complex with Argonaute proteins. The scientific significance of these small RNA-based regulatory pathways was recognized by the awarding of the Nobel Prize in 2006 for the discovery of RNAi and by the recently awarded 2024 Nobel Prize for the discovery of miRNAs. This reprint is mainly a tribute to the diversity of the miRNA pathway. The selected articles provide an overview not only of some molecular aspects of the maturation of these tiny regulators but also provide evidence of how miRNAs control cell proliferation and differentiation and how their misregulation could lead to the formation of various types of cancer. As certain gene therapy applications also involve miRNA-based strategies, the importance of understanding the molecular details of this pathway clearly extends beyond pure scientific interest. This collection of articles not only presents scientific discoveries using cutting-edge technologies in several model systems but also provides evidence of how modern molecular genetics, as well as molecular medicine, can benefit from an in-depth understanding of the miRNA pathway. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -RNA interference (RNAi) is a mechanism regulating gene transcript levels by either transcriptional gene silencing (TGS) or by posttranscriptional gene silencing (PTGS), which acts in genome maintenance and the regulation of development. This book show the role of Dicer proteins in the moss Physcomitrella patens, which has four Dicers (DICER-LIKE 1a (DCL1a), DCL1b, DCL3 and DCL4). The Physcomitrella patens was chosen because the dual functions of Dicers in miRNA biogenesis and target cleavage are separable in this species. Using targeted knockout-mutants of Physcomitrella patens, it was shown that DCL1a is required for miRNA biogenesis and DCL1b is required for miRNA-induced target RNA cleavage. Based on these data from Physcomitrella patens a model is proposed for the gene-specific control of transcription factors upon dysfunctions of the RNAi machinery. Similar control mechanisms could be exist in other eukaryotes as well. Also this book provide evidence that artificial miRNAs (amiRNAs) can be used as an alternative tool for studying gene functions in Physcomitrella patens. 128 pp. Englisch.

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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Khraiwesh BaselDr. Basel Khraiwesh is Postdoctoral Fellow at the Plant Stress Genomic and Technology Research Center at KAUST University. He has previously worked at other academic institutions such as the VIB Department of Plant Sys.

Hardcover. Condition: new. Hardcover. One of the most important breakthroughs of the 20th century was the discovery of how short RNA molecules from the genomic "dark matter" can control invasive genetic elements or fine-tune endogenous gene expression. The collective name of these pathways is RNA interference (RNAi), or "gene silencing", and the main players here are short, single-stranded RNA molecules in complex with Argonaute proteins. The scientific significance of these small RNA-based regulatory pathways was recognized by the awarding of the Nobel Prize in 2006 for the discovery of RNAi and by the recently awarded 2024 Nobel Prize for the discovery of miRNAs. This reprint is mainly a tribute to the diversity of the miRNA pathway. The selected articles provide an overview not only of some molecular aspects of the maturation of these tiny regulators but also provide evidence of how miRNAs control cell proliferation and differentiation and how their misregulation could lead to the formation of various types of cancer. As certain gene therapy applications also involve miRNA-based strategies, the importance of understanding the molecular details of this pathway clearly extends beyond pure scientific interest. This collection of articles not only presents scientific discoveries using cutting-edge technologies in several model systems but also provides evidence of how modern molecular genetics, as well as molecular medicine, can benefit from an in-depth understanding of the miRNA pathway. This item is printed on demand. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.

Hardcover. Condition: new. Hardcover. One of the most important breakthroughs of the 20th century was the discovery of how short RNA molecules from the genomic "dark matter" can control invasive genetic elements or fine-tune endogenous gene expression. The collective name of these pathways is RNA interference (RNAi), or "gene silencing", and the main players here are short, single-stranded RNA molecules in complex with Argonaute proteins. The scientific significance of these small RNA-based regulatory pathways was recognized by the awarding of the Nobel Prize in 2006 for the discovery of RNAi and by the recently awarded 2024 Nobel Prize for the discovery of miRNAs. This reprint is mainly a tribute to the diversity of the miRNA pathway. The selected articles provide an overview not only of some molecular aspects of the maturation of these tiny regulators but also provide evidence of how miRNAs control cell proliferation and differentiation and how their misregulation could lead to the formation of various types of cancer. As certain gene therapy applications also involve miRNA-based strategies, the importance of understanding the molecular details of this pathway clearly extends beyond pure scientific interest. This collection of articles not only presents scientific discoveries using cutting-edge technologies in several model systems but also provides evidence of how modern molecular genetics, as well as molecular medicine, can benefit from an in-depth understanding of the miRNA pathway. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.

Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -RNA interference (RNAi) is a mechanism regulating gene transcript levels by either transcriptional gene silencing (TGS) or by posttranscriptional gene silencing (PTGS), which acts in genome maintenance and the regulation of development. This book show the role of Dicer proteins in the moss Physcomitrella patens, which has four Dicers (DICER-LIKE 1a (DCL1a), DCL1b, DCL3 and DCL4). The Physcomitrella patens was chosen because the dual functions of Dicers in miRNA biogenesis and target cleavage are separable in this species. Using targeted knockout-mutants of Physcomitrella patens, it was shown that DCL1a is required for miRNA biogenesis and DCL1b is required for miRNA-induced target RNA cleavage. Based on these data from Physcomitrella patens a model is proposed for the gene-specific control of transcription factors upon dysfunctions of the RNAi machinery. Similar control mechanisms could be exist in other eukaryotes as well. Also this book provide evidence that artificial miRNAs (amiRNAs) can be used as an alternative tool for studying gene functions in Physcomitrella patens.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 128 pp. Englisch.

Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - RNA interference (RNAi) is a mechanism regulating gene transcript levels by either transcriptional gene silencing (TGS) or by posttranscriptional gene silencing (PTGS), which acts in genome maintenance and the regulation of development. This book show the role of Dicer proteins in the moss Physcomitrella patens, which has four Dicers (DICER-LIKE 1a (DCL1a), DCL1b, DCL3 and DCL4). The Physcomitrella patens was chosen because the dual functions of Dicers in miRNA biogenesis and target cleavage are separable in this species. Using targeted knockout-mutants of Physcomitrella patens, it was shown that DCL1a is required for miRNA biogenesis and DCL1b is required for miRNA-induced target RNA cleavage. Based on these data from Physcomitrella patens a model is proposed for the gene-specific control of transcription factors upon dysfunctions of the RNAi machinery. Similar control mechanisms could be exist in other eukaryotes as well. Also this book provide evidence that artificial miRNAs (amiRNAs) can be used as an alternative tool for studying gene functions in Physcomitrella patens.

Buch. Condition: Neu. RNA Interference Pathways | Buch | Englisch | 2025 | MDPI AG | EAN 9783725851515 | Verantwortliche Person für die EU: Libri GmbH, Europaallee 1, 36244 Bad Hersfeld, gpsr[at]libri[dot]de | Anbieter: preigu Print on Demand.