Structure Based Drug Discovery (91 results)
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Seller: Anybook.com, Lincoln, United KingdomAnybook.com
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Condition: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,650grams, ISBN:9781402044069.
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Condition: Poor. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Book contains pencil & highlighter markings. In poor condition, suitable as a reading copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,400…grams, ISBN:9780854043514.
Structure-Based Drug Discovery: An Overview
Brown, David; Flocco, Maria M; Barril, Xavier; Soliva, Robert; Davis, Ben; Hubbard, Julia; Leach, Andrew; Hann, Michael
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Hardcover. Condition: Very Good. No Jacket. May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less.
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Condition: New. pp. 396.
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- Hardcover
Seller: Majestic Books, Hounslow, United KingdomMajestic Books
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Condition: New. pp. 396 130 Illus. (5 Col.).
- Hardcover
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- First Edition
Seller: killarneybooks, Inagh, CLARE, Irelandkillarneybooks
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Hardcover. Condition: Good. 1st Edition. Oversized hardcover, xv + 352 pages, NOT ex-library. Shipping weight over 1kg. Great interior, clean and bright throughout with unmarked text, free of inscriptions and stamps, firmly bound. An external 'mängelexemplar' stamp on the upper outer page edges. Torn & glued tips of the lower ou…ter corners of the boards. Issued without a dust jacket. -- A guide to modern computational tools used to design and refine drug candidates, it focuses on how molecular simulations can complement or even replace traditional laboratory assays to produce faster, more accurate results in drug design. Core Themes and Structure: The book is organized into three distinct parts that transition from theoretical foundations to practical real-world use: Part I: Principles: Introduces the fundamental tools used in biomolecular simulation, describing common methodologies for modeling drugs and their targets while analyzing the accuracy of these predictions. Part II: Advanced Algorithms: Explores specialized techniques like enhanced sampling, which helps researchers observe rare molecular events, and Markov State Models to understand the long-term dynamics of protein-ligand binding. Part III: Applications and Success Stories: Presents case studies where these computational methods were successfully applied in real-life drug discovery projects. Key Scientific Focus: - Dynamics over Rigidity [moving beyond viewing proteins as static structures, the text emphasizes protein flexibility and how understanding its movement is crucial for designing potent compounds against dynamic drug targets like RAS proteins]; - Integration with Data [a major focus is on how to integrate computational modeling with other experimental data, such as X-ray and NMR findings, to refine molecular structures]; - Accuracy of Force Fields [the authors provide a detailed discussion on the strengths and limitations of molecular mechanics (MM) force fields, which are the mathematical models used to calculate the energy of molecular systems. The work is specifically written for medicinal chemists, structural biologists, and pharmaceutical industry professionals. It is designed to be accessible to students and newcomers while providing the in-depth methodological detail required by experienced researchers.
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Condition: New. pp. 278.
- Hardcover
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- Hardcover
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- Hardcover
Seller: Kennys Bookshop and Art Galleries Ltd., Galway, GY, IrelandKennys Bookshop and Art Galleries Ltd.
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Condition: New. Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads. Editor(s): Tari, Leslie W. Series: Methods in Molec…ular Biology. Num Pages: 385 pages, 19 black & white tables, biography. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 262 x 180 x 27. Weight in Grams: 900. . 2012. 2012. Hardback. . . . .
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- Hardcover
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Condition: Sehr gut. Zustand: Sehr gut | Seiten: 396 | Sprache: Englisch | Produktart: Bücher | The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tack…le difficult biological targets with a high probability of success: intact bacterial ribosomes have been structurally elucidated, as well as eukaryotic trans-membrane proteins like the potassium channel and GPCRs. It is now possible for medicinal chemists to have access to structural information on their latest small molecule candidates bound to the therapeutic target within days of compound synthesis, allowing structure guided ligand optimization to occur in "real time". Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads. Written in the successful Methods in Molecular Biology¿ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Structure-Based Drug Discovery aims to provide scientists interested in adding SBDD to their arsenal of drug discovery methods with well-honed, up-to-date methodologies.
