This revised fifth edition has been significantly updated to reflect recent advances in developmental and molecular biology and embyrology. Every chapter has been revised to reflect new findings in research and their clinical implications. Recent advances in developmental biology affecting knowledge about the cause of birth defects and prenatal management of foetuses are carefully integrated into this comprehensive, clinically oriented book that is designed to be easy to read.

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Emphasizes clinical aspects by using a wealth of case studies, clinical correlations, and hundreds of illustrations

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