Cellular and Molecular Toxicology: Comprehensive Toxicology; Volume 14

Heuvel, John P. Vanden, William F. Greenlee & Gary H. Perdew & William B. Mattes

ISBN 10: 0444508686 / ISBN 13: 9780444508683

Published by Elsevier Science, The Netherlands, 2002

About this Item

Hardcover with dustjacket, clean, crisp copy, book looks new, no remarkable flaws, jacket is in excellent condition with one minor flaw: mild rubbing to the glossy cover, a professional (removable) mylar cover is included; 646 pages.

Seller Inventory # 040375

Bibliographic Details

• Title: Cellular and Molecular Toxicology: Comprehensive Toxicology; Volume 14
• Publisher: Elsevier Science, The Netherlands
• Publication Date: 2002
• Language: English
• ISBN 10: 0444508686
• ISBN 13: 9780444508683
• Binding: Hardcover
• Edition: 1st Edition.
• Condition: Fine
• Dust Jacket Condition: Near Fine
• Seller catalogs:
  • Science

About this title

Synopsis

Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately.

Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response.

Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation.

A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

About the Author

William B. Mattes, PhD, DABT, Senior Director of COPD Biomarkers Qualification Consortium, COPD Foundation and Founder and Principal, PharmPoint Consulting