Classics in Total Synthesis IV is a compilation of highly important synthetic methods which lead to complex molecules with valuable properties. From the complex architectures of natural products to the streamlined synthesis of functional molecules, each chapter in Classics in Total Synthesis IV unfolds a unique story. The interplay of mechanisms, reactivity, selectivity, and stereochemical aspects is thoroughly examined, echoing the pedagogical format that has become synonymous with this series. Well-designed graphics are included throughout, and all important parts of the reaction sequences are highlighted.

This volume encapsulates the culmination of new methodologies, emerging trends, and a selection of significant total syntheses undertaken from 2009 to 2022 while additionally including two earlier syntheses from 1979 and 1992 for comparison and to highlight the development of organic synthesis over the past decades. The careful balance between historical context, comments on the molecules’ impact to humankind, and the design and execution aspects of each synthesis creates a narrative that is not only clear but also intellectually stimulating.

Written by K. C. Nicolaou, Ruocheng Yu and Stephan Rigol, Classics in Total Synthesis IV includes 16 chapters covering:

Coupling and rearrangement reactions
Recent advances in nonenzymatic enantioselective cyclization
Cycloaddition and annulation reactions
C-H functionalization and transition metal-mediated C-H activation
Electroorganic chemistry and visible-light photoredox catalysis
HAT-initiated olefin hydrogenation, isomerization, and hydrofunctionalization

Joining its predecessors in weaving together the threads of scientific discovery, challenge, and intellectual pursuit and establishing strong connections with biology and medicine, Classics in Total Synthesis IV is an essential reference for all future and present synthetic organic chemists.

About the Author

K. C. Nicolaou is the Harry C. and Olga K. Wiess Chair in Natural Sciences at Rice University (Houston, USA). The impact of his work in chemistry, biology, and medicine flows from his contributions to chemical synthesis as described in over 800 publications. He is the recipient of numerous Prizes, Awards and Honors and has been elected to several Academies.

Ruocheng Yu is a postdoctoral fellow in the laboratory of Emily Balskus at Harvard University (Cambridge, USA). He pursued his doctoral studies under the guidance of K. C. Nicolaou at The Scripps Research Institute (La Jolla, USA), and later Rice University (Houston, USA).

Stephan Rigol joined the group of K. C. Nicolaou at Rice University (Houston, USA), after completing his doctorate at Leipzig University (Germany). He is currently conducting research in the field of natural products chemistry with a particular focus on molecules with antibacterial and anti-cancer activities.

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