Denitrogenative Transformation of Nitrogen Heterocycles: Synthesis, Reactions and Applications

Comprehensive resource exploring a unique chemical transformation that generates new compounds with diverse properties for modern organic synthesis research

Denitrogenative Transformation of Nitrogen Heterocycles explores all 10 polynitrogen heterocycles that are known to undergo denitrogenative transformations to date. Following highlights on the remarkable modifications encountered in the synthesis of nitrogen heterocycles, the chapters use a reaction-based approach to explain denitrogenative transformations in detail.

This book covers the exponential growth in scientific literature in the last few decades for denitrogenative reactions of polynitrogen heterocycles which play a key role in natural products, medicinal chemistry, pharmaceuticals, biochemistry, and material sciences. This book also discusses denitrogenative cascade reactions, which accomplish powerful transformations from simple polynitrogen heterocycles to more complex molecules in modern synthetic chemistry.

Written by a highly qualified academic with significant experience in the field, Denitrogenative Transformation of Nitrogen Heterocycles covers sample topics including:

• Transannulation of N-sulfonyl-1,2,3-triazoles with polar multiple bonds such as carbonyls and nitriles and non-polar multiple bonds such as alkenes, alkynes, and allenes
• Insertion of azavinyl carbenes to C–X/X–X bond, denitrogenative rearrangements of N-sulfonyl-1,2,3-triazoles, and denitrogenative transformations of NH- and N-fluoroalkyl-1,2,3-triazoles
• Metal-catalyzed and metal-free denitrogenative transformations of pyridotriazoles and denitrogenative transannulation of benzotriazoles and thiadiazoles
• Denitrogenative transformations of tetrazoles and radical denitrogenative transformations of polynitrogen heterocycles

The first book of its kind on the subject, Denitrogenative Transformation of Nitrogen Heterocycles is an essential reference for researchers and scientists working in organic chemistry, organometallic chemistry, and transition metal catalysis, as well as academics and industry professionals in related fields.

Pazhamalai Anbarasan obtained his Ph.D. from the Indian Institute of Science (IISc), Bangalore, under the guidance of Prof. Kavirayani R. Prasad. After spending a year as a research associate at the IISc, he moved to Germany as an Alexander-von-Humboldt foundation post-doctoral fellow to join the group of Prof. Matthias Beller at the Leibniz Institute for Catalysis (LIKAT). After spending a year in the group of Prof. Dean Toste at the University of California, Berkely, he returned to India in December 2011 to start his academic career at the Department of Chemistry, Indian Institute of Technology Madras (IIT Madras), where currently he is a professor. His research program is focused on the development of new synthetic strategies employing transition-metal catalysis with special focus on asymmetric synthesis and their implementation in organic synthesis.